EEU30847.1 protein (Lactobacillus coleohominis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

EEU30847.1

ABC transporter, substrate-binding protein. (303 aa)

Predicted Functional Partners:

EEU30849.1

0.970

EEU30848.1

0.941

EEU29934.1

0.899

EEU29804.1

0.880

EEU29803.1

0.804

EEU29933.1

0.797

EEU30399.1

0.705

EEU30850.1

0.529

EEU30851.1

0.529

EEU30846.1

0.482

Your Current Organism:

Lactobacillus coleohominis

NCBI taxonomy Id: 575594
Other names: L. coleohominis 101-4-CHN, Lactobacillus coleohominis 101-4-CHN

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EEU29803.1	EEU29804.1	HMPREF0501_01268	HMPREF0501_01269	ABC transporter, ATP-binding protein; 5' partial; truncated CDS; unextendable partial coding region.	ABC 3 transport family protein; Truncated CDS.	0.985
EEU29803.1	EEU29934.1	HMPREF0501_01268	HMPREF0501_01399	ABC transporter, ATP-binding protein; 5' partial; truncated CDS; unextendable partial coding region.	ABC 3 transport family protein.	0.955
EEU29803.1	EEU30399.1	HMPREF0501_01268	HMPREF0501_00777	ABC transporter, ATP-binding protein; 5' partial; truncated CDS; unextendable partial coding region.	FeoA domain protein; 5' partial; truncated CDS; unextendable partial coding region.	0.608
EEU29803.1	EEU30847.1	HMPREF0501_01268	HMPREF0501_00252	ABC transporter, ATP-binding protein; 5' partial; truncated CDS; unextendable partial coding region.	ABC transporter, substrate-binding protein.	0.804
EEU29803.1	EEU30849.1	HMPREF0501_01268	HMPREF0501_00254	ABC transporter, ATP-binding protein; 5' partial; truncated CDS; unextendable partial coding region.	ABC 3 transport family protein.	0.955
EEU29804.1	EEU29803.1	HMPREF0501_01269	HMPREF0501_01268	ABC 3 transport family protein; Truncated CDS.	ABC transporter, ATP-binding protein; 5' partial; truncated CDS; unextendable partial coding region.	0.985
EEU29804.1	EEU29933.1	HMPREF0501_01269	HMPREF0501_01398	ABC 3 transport family protein; Truncated CDS.	ABC transporter, ATP-binding protein.	0.929
EEU29804.1	EEU30399.1	HMPREF0501_01269	HMPREF0501_00777	ABC 3 transport family protein; Truncated CDS.	FeoA domain protein; 5' partial; truncated CDS; unextendable partial coding region.	0.632
EEU29804.1	EEU30847.1	HMPREF0501_01269	HMPREF0501_00252	ABC 3 transport family protein; Truncated CDS.	ABC transporter, substrate-binding protein.	0.880
EEU29804.1	EEU30848.1	HMPREF0501_01269	HMPREF0501_00253	ABC 3 transport family protein; Truncated CDS.	ABC transporter, ATP-binding protein.	0.933
EEU29933.1	EEU29804.1	HMPREF0501_01398	HMPREF0501_01269	ABC transporter, ATP-binding protein.	ABC 3 transport family protein; Truncated CDS.	0.929
EEU29933.1	EEU29934.1	HMPREF0501_01398	HMPREF0501_01399	ABC transporter, ATP-binding protein.	ABC 3 transport family protein.	0.991
EEU29933.1	EEU30399.1	HMPREF0501_01398	HMPREF0501_00777	ABC transporter, ATP-binding protein.	FeoA domain protein; 5' partial; truncated CDS; unextendable partial coding region.	0.608
EEU29933.1	EEU30847.1	HMPREF0501_01398	HMPREF0501_00252	ABC transporter, ATP-binding protein.	ABC transporter, substrate-binding protein.	0.797
EEU29933.1	EEU30849.1	HMPREF0501_01398	HMPREF0501_00254	ABC transporter, ATP-binding protein.	ABC 3 transport family protein.	0.962
EEU29934.1	EEU29803.1	HMPREF0501_01399	HMPREF0501_01268	ABC 3 transport family protein.	ABC transporter, ATP-binding protein; 5' partial; truncated CDS; unextendable partial coding region.	0.955
EEU29934.1	EEU29933.1	HMPREF0501_01399	HMPREF0501_01398	ABC 3 transport family protein.	ABC transporter, ATP-binding protein.	0.991
EEU29934.1	EEU30399.1	HMPREF0501_01399	HMPREF0501_00777	ABC 3 transport family protein.	FeoA domain protein; 5' partial; truncated CDS; unextendable partial coding region.	0.632
EEU29934.1	EEU30847.1	HMPREF0501_01399	HMPREF0501_00252	ABC 3 transport family protein.	ABC transporter, substrate-binding protein.	0.899
EEU29934.1	EEU30848.1	HMPREF0501_01399	HMPREF0501_00253	ABC 3 transport family protein.	ABC transporter, ATP-binding protein.	0.956

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Network Stats

number of nodes:

11

number of edges:

49

average node degree:

8.91

avg. local clustering coefficient:

0.923

expected number of edges:

17

PPI enrichment p-value:

1.76e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004252

Serine-type endopeptidase activity

3 of 32

1.71

0.84

0.0220

GO:0008233

Peptidase activity

4 of 191

1.05

0.54

0.0456

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5736

Peptidase S8, subtilisin-related

4 of 6

2.56

3.07

1.60e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02024

Quorum sensing

7 of 237

1.2

1.4

6.59e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031012

Extracellular matrix

3 of 23

1.85

1.33

0.0021

GOCC:0005576

Extracellular region

6 of 268

1.08

0.91

0.0012

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00082

Subtilase family

4 of 13

2.22

2.53

1.05e-05

PF13585

CHU_C Type IX secretion signal domain

3 of 24

1.83

1.16

0.0048

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036852

Peptidase S8/S53 domain superfamily

4 of 14

2.19

2.29

3.28e-05

IPR000209

Peptidase S8/S53 domain

4 of 14

2.19

2.29

3.28e-05

IPR015500

Peptidase S8, subtilisin-related

3 of 10

2.21

1.64

0.00076

IPR026341

Gliding motility-associated, C-terminal domain

3 of 16

2.01

1.4

0.0019

IPR022398

Peptidase S8, subtilisin, His-active site

2 of 6

2.26

0.83

0.0299

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