| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EEU29770.1 | EEU29895.1 | HMPREF0501_01564 | HMPREF0501_01360 | Putative succinate-semialdehyde dehydrogenase (NAD(P)(+)); Belongs to the aldehyde dehydrogenase family. | Putative L-serine dehydratase, iron-sulfur-dependent, beta subunit. | 0.888 |
| EEU29770.1 | EEU29896.1 | HMPREF0501_01564 | HMPREF0501_01361 | Putative succinate-semialdehyde dehydrogenase (NAD(P)(+)); Belongs to the aldehyde dehydrogenase family. | L-serine dehydratase, iron-sulfur-dependent, alpha subunit family protein; Truncated CDS. | 0.888 |
| EEU29770.1 | EEU30186.1 | HMPREF0501_01564 | HMPREF0501_01191 | Putative succinate-semialdehyde dehydrogenase (NAD(P)(+)); Belongs to the aldehyde dehydrogenase family. | Homoserine dehydrogenase. | 0.593 |
| EEU29770.1 | EEU30253.1 | HMPREF0501_01564 | HMPREF0501_00631 | Putative succinate-semialdehyde dehydrogenase (NAD(P)(+)); Belongs to the aldehyde dehydrogenase family. | Hypothetical protein; 5' partial. | 0.936 |
| EEU29770.1 | adh | HMPREF0501_01564 | HMPREF0501_01183 | Putative succinate-semialdehyde dehydrogenase (NAD(P)(+)); Belongs to the aldehyde dehydrogenase family. | Aldehyde-alcohol dehydrogenase 2; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | 0.754 |
| EEU29770.1 | glyA | HMPREF0501_01564 | HMPREF0501_00284 | Putative succinate-semialdehyde dehydrogenase (NAD(P)(+)); Belongs to the aldehyde dehydrogenase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.498 |
| EEU29770.1 | pdxB-2 | HMPREF0501_01564 | HMPREF0501_00611 | Putative succinate-semialdehyde dehydrogenase (NAD(P)(+)); Belongs to the aldehyde dehydrogenase family. | 4-phosphoerythronate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.453 |
| EEU29895.1 | EEU29770.1 | HMPREF0501_01360 | HMPREF0501_01564 | Putative L-serine dehydratase, iron-sulfur-dependent, beta subunit. | Putative succinate-semialdehyde dehydrogenase (NAD(P)(+)); Belongs to the aldehyde dehydrogenase family. | 0.888 |
| EEU29895.1 | EEU29896.1 | HMPREF0501_01360 | HMPREF0501_01361 | Putative L-serine dehydratase, iron-sulfur-dependent, beta subunit. | L-serine dehydratase, iron-sulfur-dependent, alpha subunit family protein; Truncated CDS. | 0.999 |
| EEU29895.1 | EEU29897.1 | HMPREF0501_01360 | HMPREF0501_01362 | Putative L-serine dehydratase, iron-sulfur-dependent, beta subunit. | Hypothetical protein. | 0.649 |
| EEU29895.1 | EEU30186.1 | HMPREF0501_01360 | HMPREF0501_01191 | Putative L-serine dehydratase, iron-sulfur-dependent, beta subunit. | Homoserine dehydrogenase. | 0.939 |
| EEU29895.1 | EEU30253.1 | HMPREF0501_01360 | HMPREF0501_00631 | Putative L-serine dehydratase, iron-sulfur-dependent, beta subunit. | Hypothetical protein; 5' partial. | 0.922 |
| EEU29895.1 | EEU30926.1 | HMPREF0501_01360 | HMPREF0501_00331 | Putative L-serine dehydratase, iron-sulfur-dependent, beta subunit. | ACT domain protein; Belongs to the UPF0237 family. | 0.451 |
| EEU29895.1 | adh | HMPREF0501_01360 | HMPREF0501_01183 | Putative L-serine dehydratase, iron-sulfur-dependent, beta subunit. | Aldehyde-alcohol dehydrogenase 2; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | 0.465 |
| EEU29895.1 | glyA | HMPREF0501_01360 | HMPREF0501_00284 | Putative L-serine dehydratase, iron-sulfur-dependent, beta subunit. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.964 |
| EEU29895.1 | pdxB-2 | HMPREF0501_01360 | HMPREF0501_00611 | Putative L-serine dehydratase, iron-sulfur-dependent, beta subunit. | 4-phosphoerythronate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.456 |
| EEU29895.1 | thrB | HMPREF0501_01360 | HMPREF0501_01190 | Putative L-serine dehydratase, iron-sulfur-dependent, beta subunit. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.942 |
| EEU29896.1 | EEU29770.1 | HMPREF0501_01361 | HMPREF0501_01564 | L-serine dehydratase, iron-sulfur-dependent, alpha subunit family protein; Truncated CDS. | Putative succinate-semialdehyde dehydrogenase (NAD(P)(+)); Belongs to the aldehyde dehydrogenase family. | 0.888 |
| EEU29896.1 | EEU29895.1 | HMPREF0501_01361 | HMPREF0501_01360 | L-serine dehydratase, iron-sulfur-dependent, alpha subunit family protein; Truncated CDS. | Putative L-serine dehydratase, iron-sulfur-dependent, beta subunit. | 0.999 |
| EEU29896.1 | EEU29897.1 | HMPREF0501_01361 | HMPREF0501_01362 | L-serine dehydratase, iron-sulfur-dependent, alpha subunit family protein; Truncated CDS. | Hypothetical protein. | 0.780 |