| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EEU30304.1 | apt | HMPREF0501_00682 | HMPREF0501_00073 | Inosine-uridine preferring nucleoside hydrolase. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.933 |
| EEU30304.1 | guaC | HMPREF0501_00682 | HMPREF0501_01562 | Inosine-uridine preferring nucleoside hydrolase. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.439 |
| EEU30304.1 | hpt | HMPREF0501_00682 | HMPREF0501_01428 | Inosine-uridine preferring nucleoside hydrolase. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.937 |
| EEU30304.1 | purA | HMPREF0501_00682 | HMPREF0501_01563 | Inosine-uridine preferring nucleoside hydrolase. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.468 |
| EEU30304.1 | tilS | HMPREF0501_00682 | HMPREF0501_01427 | Inosine-uridine preferring nucleoside hydrolase. | tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. | 0.916 |
| EEU30304.1 | xpt | HMPREF0501_00682 | HMPREF0501_00841 | Inosine-uridine preferring nucleoside hydrolase. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.933 |
| EEU30345.1 | apt | HMPREF0501_00723 | HMPREF0501_00073 | Guanylate kinase. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.959 |
| EEU30345.1 | gmk | HMPREF0501_00723 | HMPREF0501_00421 | Guanylate kinase. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.948 |
| EEU30345.1 | guaA | HMPREF0501_00723 | HMPREF0501_01335 | Guanylate kinase. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.987 |
| EEU30345.1 | guaC | HMPREF0501_00723 | HMPREF0501_01562 | Guanylate kinase. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.937 |
| EEU30345.1 | hpt | HMPREF0501_00723 | HMPREF0501_01428 | Guanylate kinase. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.942 |
| EEU30345.1 | tilS | HMPREF0501_00723 | HMPREF0501_01427 | Guanylate kinase. | tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. | 0.927 |
| EEU30345.1 | xpt | HMPREF0501_00723 | HMPREF0501_00841 | Guanylate kinase. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.959 |
| apt | EEU30304.1 | HMPREF0501_00073 | HMPREF0501_00682 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine-uridine preferring nucleoside hydrolase. | 0.933 |
| apt | EEU30345.1 | HMPREF0501_00073 | HMPREF0501_00723 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase. | 0.959 |
| apt | gmk | HMPREF0501_00073 | HMPREF0501_00421 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.956 |
| apt | guaA | HMPREF0501_00073 | HMPREF0501_01335 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.992 |
| apt | guaC | HMPREF0501_00073 | HMPREF0501_01562 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.966 |
| apt | hpt | HMPREF0501_00073 | HMPREF0501_01428 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.969 |
| apt | purA | HMPREF0501_00073 | HMPREF0501_01563 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.878 |