STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (205 aa)    
Predicted Functional Partners:
guaA
GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP.
 
 
 0.973
rpoZ
DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
 
  
 0.962
xpt
Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
  
 
 0.938
EFI42494.1
Putative GMP synthase (glutamine-hydrolyzing) domain protein.
  
 
 0.936
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
  
 
 0.936
EFI42190.1
Hypothetical protein; Belongs to the RemA family.
  
    0.930
pyk
Pyruvate kinase; Belongs to the pyruvate kinase family.
  
 
 0.914
purD
Phosphoribosylformylglycinamidine synthase; Belongs to the GARS family.
   
 
 0.906
EFI41903.1
Putative guanylate kinase.
  
  
 
0.903
relA
GTP diphosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
  
 
 0.903
Your Current Organism:
Peptoniphilus sp. F0131
NCBI taxonomy Id: 575609
Other names: P. sp. oral taxon 386 str. F0131, Peptoniphilus sp. oral taxon 386 str. F0131, Peptoniphilus sp. oral taxon 386 strain F0131
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