node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
VS_0347 | VS_1558 | VS_0347 | VS_1558 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Putative amidohydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.714 |
VS_0347 | lipA | VS_0347 | VS_0707 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.597 |
VS_0347 | lipB | VS_0347 | VS_0708 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Lipoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.590 |
VS_0709 | lipA | VS_0709 | VS_0707 | Hypothetical protein; Belongs to the UPF0250 family. | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.606 |
VS_0709 | lipB | VS_0709 | VS_0708 | Hypothetical protein; Belongs to the UPF0250 family. | Lipoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.741 |
VS_1558 | VS_0347 | VS_1558 | VS_0347 | Putative amidohydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.714 |
VS_1558 | lipA | VS_1558 | VS_0707 | Putative amidohydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.598 |
VS_1558 | lipB | VS_1558 | VS_0708 | Putative amidohydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Lipoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.599 |
VS_2242 | VS_2540 | VS_2242 | VS_2540 | Dihydrolipoyllysine-residue succinyltransferase (component of 2-oxoglutaratedehydrogenase complex); E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). | Dihydrolipoyl dehydrogenase. | 0.996 |
VS_2242 | VS_II0088 | VS_2242 | VS_II0088 | Dihydrolipoyllysine-residue succinyltransferase (component of 2-oxoglutaratedehydrogenase complex); E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). | Lipoate-protein ligase A. | 0.934 |
VS_2242 | gcvH | VS_2242 | VS_II0819 | Dihydrolipoyllysine-residue succinyltransferase (component of 2-oxoglutaratedehydrogenase complex); E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.903 |
VS_2242 | gcvP | VS_2242 | VS_II0820 | Dihydrolipoyllysine-residue succinyltransferase (component of 2-oxoglutaratedehydrogenase complex); E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). | Glycine dehydrogenase (Glycine cleavage system P-protein); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.935 |
VS_2242 | lipA | VS_2242 | VS_0707 | Dihydrolipoyllysine-residue succinyltransferase (component of 2-oxoglutaratedehydrogenase complex); E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.617 |
VS_2242 | lipB | VS_2242 | VS_0708 | Dihydrolipoyllysine-residue succinyltransferase (component of 2-oxoglutaratedehydrogenase complex); E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). | Lipoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.631 |
VS_2540 | VS_2242 | VS_2540 | VS_2242 | Dihydrolipoyl dehydrogenase. | Dihydrolipoyllysine-residue succinyltransferase (component of 2-oxoglutaratedehydrogenase complex); E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). | 0.996 |
VS_2540 | VS_2541 | VS_2540 | VS_2541 | Dihydrolipoyl dehydrogenase. | Dihydrolipoyllysine-residue acetyltransferase component of pyruvatedehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.997 |
VS_2540 | VS_II0088 | VS_2540 | VS_II0088 | Dihydrolipoyl dehydrogenase. | Lipoate-protein ligase A. | 0.824 |
VS_2540 | gcvH | VS_2540 | VS_II0819 | Dihydrolipoyl dehydrogenase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.950 |
VS_2540 | gcvP | VS_2540 | VS_II0820 | Dihydrolipoyl dehydrogenase. | Glycine dehydrogenase (Glycine cleavage system P-protein); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.938 |
VS_2540 | lipA | VS_2540 | VS_0707 | Dihydrolipoyl dehydrogenase. | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.640 |