| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| VS_0315 | VS_0483 | VS_0315 | VS_0483 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.991 |
| VS_0315 | VS_1282 | VS_0315 | VS_1282 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Putative methylcobalamin:homocysteine methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.980 |
| VS_0315 | VS_1743 | VS_0315 | VS_1743 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Putative Cys/Met metabolism pyridoxal-phosphate-dependent enzyme; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.963 |
| VS_0315 | VS_1982 | VS_0315 | VS_1982 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cystathionine beta-lyase. | 0.985 |
| VS_0315 | VS_2169 | VS_0315 | VS_2169 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cysteine synthase. | 0.943 |
| VS_0315 | VS_2289 | VS_0315 | VS_2289 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.943 |
| VS_0315 | VS_2893 | VS_0315 | VS_2893 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Bifunctional aspartokinase/homoserine dehydrogenase II; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.991 |
| VS_0315 | VS_2894 | VS_0315 | VS_2894 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cystathionine gamma-synthase. | 0.972 |
| VS_0315 | VS_II0483 | VS_0315 | VS_II0483 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Thiosulfate sulfurtransferase. | 0.829 |
| VS_0315 | metE | VS_0315 | VS_1145 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.985 |
| VS_0483 | VS_0315 | VS_0483 | VS_0315 | Homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.991 |
| VS_0483 | VS_1282 | VS_0483 | VS_1282 | Homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Putative methylcobalamin:homocysteine methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.964 |
| VS_0483 | VS_1743 | VS_0483 | VS_1743 | Homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Putative Cys/Met metabolism pyridoxal-phosphate-dependent enzyme; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.918 |
| VS_0483 | VS_1982 | VS_0483 | VS_1982 | Homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Cystathionine beta-lyase. | 0.966 |
| VS_0483 | VS_2169 | VS_0483 | VS_2169 | Homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Cysteine synthase. | 0.794 |
| VS_0483 | VS_2289 | VS_0483 | VS_2289 | Homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.794 |
| VS_0483 | VS_2893 | VS_0483 | VS_2893 | Homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Bifunctional aspartokinase/homoserine dehydrogenase II; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.995 |
| VS_0483 | VS_2894 | VS_0483 | VS_2894 | Homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Cystathionine gamma-synthase. | 0.966 |
| VS_0483 | metE | VS_0483 | VS_1145 | Homoserine dehydrogenase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.978 |
| VS_1282 | VS_0315 | VS_1282 | VS_0315 | Putative methylcobalamin:homocysteine methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.980 |