| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| VS_0315 | VS_2306 | VS_0315 | VS_2306 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine cleavage system transcriptional. | 0.869 |
| VS_0315 | VS_II0105 | VS_0315 | VS_II0105 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Putative dihydrofolate reductase. | 0.782 |
| VS_0315 | VS_II0816 | VS_0315 | VS_II0816 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine cleavage system T protein. | 0.973 |
| VS_0315 | gcvH | VS_0315 | VS_II0819 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.836 |
| VS_0315 | thyA | VS_0315 | VS_0527 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.622 |
| VS_0905 | VS_II0105 | VS_0905 | VS_II0105 | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | Putative dihydrofolate reductase. | 0.682 |
| VS_0905 | thyA | VS_0905 | VS_0527 | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.933 |
| VS_2306 | VS_0315 | VS_2306 | VS_0315 | Glycine cleavage system transcriptional. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.869 |
| VS_2306 | VS_II0105 | VS_2306 | VS_II0105 | Glycine cleavage system transcriptional. | Putative dihydrofolate reductase. | 0.500 |
| VS_2306 | VS_II0816 | VS_2306 | VS_II0816 | Glycine cleavage system transcriptional. | Glycine cleavage system T protein. | 0.565 |
| VS_2306 | gcvH | VS_2306 | VS_II0819 | Glycine cleavage system transcriptional. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.531 |
| VS_2306 | thyA | VS_2306 | VS_0527 | Glycine cleavage system transcriptional. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.533 |
| VS_II0104 | VS_II0105 | VS_II0104 | VS_II0105 | Putative plasmid-related protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; extrachromosomal origin. | Putative dihydrofolate reductase. | 0.576 |
| VS_II0104 | VS_II0106 | VS_II0104 | VS_II0106 | Putative plasmid-related protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; extrachromosomal origin. | Putative transcriptional regulator. | 0.783 |
| VS_II0105 | VS_0315 | VS_II0105 | VS_0315 | Putative dihydrofolate reductase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.782 |
| VS_II0105 | VS_0905 | VS_II0105 | VS_0905 | Putative dihydrofolate reductase. | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | 0.682 |
| VS_II0105 | VS_2306 | VS_II0105 | VS_2306 | Putative dihydrofolate reductase. | Glycine cleavage system transcriptional. | 0.500 |
| VS_II0105 | VS_II0104 | VS_II0105 | VS_II0104 | Putative dihydrofolate reductase. | Putative plasmid-related protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; extrachromosomal origin. | 0.576 |
| VS_II0105 | VS_II0106 | VS_II0105 | VS_II0106 | Putative dihydrofolate reductase. | Putative transcriptional regulator. | 0.792 |
| VS_II0105 | VS_II0816 | VS_II0105 | VS_II0816 | Putative dihydrofolate reductase. | Glycine cleavage system T protein. | 0.668 |