STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
10.t00063Meiotic recombination protein DMC1, putative; Belongs to the RecA family. (347 aa)    
Predicted Functional Partners:
63.t00006
DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily.
  
0.988
147.t00013
Uncharacterized protein.
   
 0.959
135.t00016
Uncharacterized protein.
  
 0.927
161.t00010
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
  
 0.868
7.t00040
DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.
  
 0.862
206.t00014
Valyl-tRNA synthetase, putative; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
  
 0.861
8.t00051
Replication factor A, putative.
  
 0.824
234.t00004
Replication factor A protein 1, putative.
  
 0.822
102.t00005
Uncharacterized protein.
  
 0.821
199.t00007
Uncharacterized protein; Belongs to the PI3/PI4-kinase family.
    
 0.815
Your Current Organism:
Entamoeba histolytica
NCBI taxonomy Id: 5759
Other names: E. histolytica
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.