44.t00003 protein (Entamoeba histolytica) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

44.t00003

Replication factor C subunit 4, putative. (329 aa)

Predicted Functional Partners:

141.t00006

0.999

135.t00016

0.999

173.t00021

0.999

277.t00004

0.999

180.t00016

0.999

161.t00010

0.999

73.t00009

0.998

318.t00007

0.998

18.t00025

0.994

1.t00017

0.978

Your Current Organism:

Entamoeba histolytica

NCBI taxonomy Id: 5759
Other names: E. histolytica

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
1.t00017	135.t00016	C4M5H3	C4M694	DNA ligase.	Uncharacterized protein.	0.946
1.t00017	141.t00006	C4M5H3	C4M5T7	DNA ligase.	Uncharacterized protein.	0.875
1.t00017	161.t00010	C4M5H3	C4M9R9	DNA ligase.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.999
1.t00017	173.t00021	C4M5H3	C4M6G5	DNA ligase.	Replication factor C familiy protein.	0.904
1.t00017	18.t00025	C4M5H3	C4LZ11	DNA ligase.	Checkpoint protein; Belongs to the HUS1 family.	0.733
1.t00017	180.t00016	C4M5H3	C4M8Z1	DNA ligase.	Activator 1 40 kDa subunit, putative.	0.881
1.t00017	277.t00004	C4M5H3	C4M7G5	DNA ligase.	Activator 1 140 kDa subunit, putative.	0.943
1.t00017	318.t00007	C4M5H3	C4M690	DNA ligase.	Activator 1 subunit, putative.	0.850
1.t00017	44.t00003	C4M5H3	C4LYB5	DNA ligase.	Replication factor C subunit 4, putative.	0.978
1.t00017	73.t00009	C4M5H3	C4M3A3	DNA ligase.	Activator 1 subunit, putative.	0.850
135.t00016	1.t00017	C4M694	C4M5H3	Uncharacterized protein.	DNA ligase.	0.946
135.t00016	141.t00006	C4M694	C4M5T7	Uncharacterized protein.	Uncharacterized protein.	0.919
135.t00016	161.t00010	C4M694	C4M9R9	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.999
135.t00016	173.t00021	C4M694	C4M6G5	Uncharacterized protein.	Replication factor C familiy protein.	0.999
135.t00016	18.t00025	C4M694	C4LZ11	Uncharacterized protein.	Checkpoint protein; Belongs to the HUS1 family.	0.721
135.t00016	180.t00016	C4M694	C4M8Z1	Uncharacterized protein.	Activator 1 40 kDa subunit, putative.	0.999
135.t00016	277.t00004	C4M694	C4M7G5	Uncharacterized protein.	Activator 1 140 kDa subunit, putative.	0.999
135.t00016	318.t00007	C4M694	C4M690	Uncharacterized protein.	Activator 1 subunit, putative.	0.999
135.t00016	44.t00003	C4M694	C4LYB5	Uncharacterized protein.	Replication factor C subunit 4, putative.	0.999
135.t00016	73.t00009	C4M694	C4M3A3	Uncharacterized protein.	Activator 1 subunit, putative.	0.999