STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HDACHistone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (448 aa)    
Predicted Functional Partners:
200.t00017
Heat shock transcription factor, putative.
  
 0.999
8.t00076
Uncharacterized protein.
    
 0.996
8.t00057
Uncharacterized protein.
   
 0.989
472.t00010
WD domain containing protein.
   
 0.987
322.t00001
WD domain containing protein.
   
 0.987
154.t00014
Uncharacterized protein.
   
 
 0.978
63.t00025
Uncharacterized protein.
   
 0.976
25.t00034
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
    
 0.961
39.t00045
Histone H2B; Belongs to the histone H2B family.
    
 0.950
48.t00008
Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.
   
 0.936
Your Current Organism:
Entamoeba histolytica
NCBI taxonomy Id: 5759
Other names: E. histolytica
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.