node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFJ00194.1 | SFJ00250.1 | SAMN04488138_101141 | SAMN04488138_101143 | Lactoylglutathione lyase. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.573 |
SFJ00194.1 | SFJ24976.1 | SAMN04488138_101141 | SAMN04488138_10369 | Lactoylglutathione lyase. | Lactoylglutathione lyase. | 0.862 |
SFJ00194.1 | SFJ44383.1 | SAMN04488138_101141 | SAMN04488138_10531 | Lactoylglutathione lyase. | Hypothetical protein. | 0.552 |
SFJ00194.1 | SFJ45644.1 | SAMN04488138_101141 | SAMN04488138_10592 | Lactoylglutathione lyase. | methylmalonyl-CoA mutase. | 0.626 |
SFJ00194.1 | SFJ57689.1 | SAMN04488138_101141 | SAMN04488138_106202 | Lactoylglutathione lyase. | (R)-ethylmalonyl-CoA mutase. | 0.626 |
SFJ00194.1 | SFJ89941.1 | SAMN04488138_101141 | SAMN04488138_113101 | Lactoylglutathione lyase. | Lactoylglutathione lyase. | 0.878 |
SFJ00194.1 | gloB | SAMN04488138_101141 | SAMN04488138_10660 | Lactoylglutathione lyase. | Hydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid. | 0.953 |
SFJ00194.1 | ilvA | SAMN04488138_101141 | SAMN04488138_1093 | Lactoylglutathione lyase. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.841 |
SFJ00194.1 | thyA | SAMN04488138_101141 | SAMN04488138_101142 | Lactoylglutathione lyase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.531 |
SFJ00194.1 | trpB | SAMN04488138_101141 | SAMN04488138_106122 | Lactoylglutathione lyase. | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.856 |
SFJ00250.1 | SFJ00194.1 | SAMN04488138_101143 | SAMN04488138_101141 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Lactoylglutathione lyase. | 0.573 |
SFJ00250.1 | thyA | SAMN04488138_101143 | SAMN04488138_101142 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
SFJ24976.1 | SFJ00194.1 | SAMN04488138_10369 | SAMN04488138_101141 | Lactoylglutathione lyase. | Lactoylglutathione lyase. | 0.862 |
SFJ24976.1 | SFJ44383.1 | SAMN04488138_10369 | SAMN04488138_10531 | Lactoylglutathione lyase. | Hypothetical protein. | 0.552 |
SFJ24976.1 | SFJ45644.1 | SAMN04488138_10369 | SAMN04488138_10592 | Lactoylglutathione lyase. | methylmalonyl-CoA mutase. | 0.626 |
SFJ24976.1 | SFJ57689.1 | SAMN04488138_10369 | SAMN04488138_106202 | Lactoylglutathione lyase. | (R)-ethylmalonyl-CoA mutase. | 0.626 |
SFJ24976.1 | gloB | SAMN04488138_10369 | SAMN04488138_10660 | Lactoylglutathione lyase. | Hydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid. | 0.856 |
SFJ24976.1 | ilvA | SAMN04488138_10369 | SAMN04488138_1093 | Lactoylglutathione lyase. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.658 |
SFJ24976.1 | trpB | SAMN04488138_10369 | SAMN04488138_106122 | Lactoylglutathione lyase. | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.691 |
SFJ44383.1 | SFJ00194.1 | SAMN04488138_10531 | SAMN04488138_101141 | Hypothetical protein. | Lactoylglutathione lyase. | 0.552 |