node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFJ12549.1 | SFJ31018.1 | SAMN04488138_10278 | SAMN04488138_103289 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | Acetolactate synthase, small subunit. | 0.997 |
SFJ12549.1 | SFJ44853.1 | SAMN04488138_10278 | SAMN04488138_10552 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | Homoserine dehydrogenase. | 0.407 |
SFJ12549.1 | SFJ67769.1 | SAMN04488138_10278 | SAMN04488138_10818 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.754 |
SFJ12549.1 | SFK05736.1 | SAMN04488138_10278 | SAMN04488138_1242 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase. | 0.692 |
SFJ12549.1 | ilvA | SAMN04488138_10278 | SAMN04488138_1093 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.798 |
SFJ12549.1 | ilvC | SAMN04488138_10278 | SAMN04488138_101245 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.944 |
SFJ12549.1 | leuA | SAMN04488138_10278 | SAMN04488138_11063 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.710 |
SFJ12549.1 | leuB | SAMN04488138_10278 | SAMN04488138_109155 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.735 |
SFJ12549.1 | leuD | SAMN04488138_10278 | SAMN04488138_109150 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.756 |
SFJ31018.1 | SFJ12549.1 | SAMN04488138_103289 | SAMN04488138_10278 | Acetolactate synthase, small subunit. | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | 0.997 |
SFJ31018.1 | SFJ31085.1 | SAMN04488138_103289 | SAMN04488138_103291 | Acetolactate synthase, small subunit. | Acetolactate synthase, large subunit. | 0.999 |
SFJ31018.1 | SFJ44853.1 | SAMN04488138_103289 | SAMN04488138_10552 | Acetolactate synthase, small subunit. | Homoserine dehydrogenase. | 0.920 |
SFJ31018.1 | SFJ67769.1 | SAMN04488138_103289 | SAMN04488138_10818 | Acetolactate synthase, small subunit. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.946 |
SFJ31018.1 | SFK05736.1 | SAMN04488138_103289 | SAMN04488138_1242 | Acetolactate synthase, small subunit. | Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase. | 0.941 |
SFJ31018.1 | ilvA | SAMN04488138_103289 | SAMN04488138_1093 | Acetolactate synthase, small subunit. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.993 |
SFJ31018.1 | ilvC | SAMN04488138_103289 | SAMN04488138_101245 | Acetolactate synthase, small subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.999 |
SFJ31018.1 | leuA | SAMN04488138_103289 | SAMN04488138_11063 | Acetolactate synthase, small subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.945 |
SFJ31018.1 | leuB | SAMN04488138_103289 | SAMN04488138_109155 | Acetolactate synthase, small subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.954 |
SFJ31018.1 | leuD | SAMN04488138_103289 | SAMN04488138_109150 | Acetolactate synthase, small subunit. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.929 |
SFJ31085.1 | SFJ31018.1 | SAMN04488138_103291 | SAMN04488138_103289 | Acetolactate synthase, large subunit. | Acetolactate synthase, small subunit. | 0.999 |