Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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htpXHeat shock protein; COGs: COG0501 Zn-dependent protease with chaperone function; InterPro IPR001915; KEGG: ppd:Ppro_3243 peptidase M48, Ste24p; PFAM: peptidase M48 Ste24p; SPTR: HtpX-2 peptidase. Metallo peptidase. MEROPS family M48B; PFAM: Peptidase family M48; Belongs to the peptidase M48B family. (278 aa)    
Predicted Functional Partners:
ADW18436.1
Protein of unknown function DUF533; COGs: COG2979 conserved hypothetical protein; InterPro IPR007486; KEGG: ppd:Ppro_3114 hypothetical protein; PFAM: protein of unknown function DUF533; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF533).
   
    0.728
ADW16558.1
Membrane protease FtsH catalytic subunit; COGs: COG0465 ATP-dependent Zn protease; InterProIPR005936: IPR003959: IPR000642: IPR003960: IPR 003593; KEGG: mfa:Mfla_1168 FtsH-2 peptidase; PFAM: peptidase M41; AAA ATPase central domain protein; PRIAM: Microtubule-severing ATPase; SMART: AAA ATPase; SPTR: FtsH-2 peptidase. Metallo peptidase. MEROPS family M41; TIGRFAM: ATP-dependent metalloprotease FtsH; PFAM: Peptidase family M41; ATPase family associated with various cellular activities (AAA); TIGRFAM: ATP-dependent metalloprotease FtsH.
   
 0.665
ADW16800.1
Membrane protease FtsH catalytic subunit; COGs: COG0465 ATP-dependent Zn protease; InterProIPR003959: IPR000642: IPR005936: IPR003960: IPR 003593; KEGG: gsu:GSU1809 cell division protein FtsH; PFAM: peptidase M41; AAA ATPase central domain protein; PRIAM: Adenosinetriphosphatase; SMART: AAA ATPase; SPTR: Cell division protein FtsH; TIGRFAM: ATP-dependent metalloprotease FtsH; PFAM: Peptidase family M41; ATPase family associated with various cellular activities (AAA); TIGRFAM: ATP-dependent metalloprotease FtsH.
   
 0.665
ftsH
Membrane protease FtsH catalytic subunit; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
   
 0.665
ADW18353.1
Membrane protease FtsH catalytic subunit; COGs: COG0465 ATP-dependent Zn protease; InterProIPR003593: IPR003959: IPR000642: IPR003960: IPR 005936; KEGG: dak:DaAHT2_0902 ATP-dependent metalloprotease FtsH; PFAM: peptidase M41; AAA ATPase central domain protein; PRIAM: Microtubule-severing ATPase; SMART: AAA ATPase; SPTR: ATP-dependent metalloprotease FtsH; TIGRFAM: ATP-dependent metalloprotease FtsH; PFAM: Peptidase family M41; ATPase family associated with various cellular activities (AAA); TIGRFAM: ATP-dependent metalloprotease FtsH.
   
 0.641
ADW17097.1
GrpE protein; COGs: COG0576 Molecular chaperone GrpE (heat shock protein); InterPro IPR000740; KEGG: dak:DaAHT2_0057 GrpE protein; PFAM: GrpE protein; SPTR: Protein grpE; PFAM: GrpE.
  
  
 0.629
ADW18971.1
Protein of unknown function UPF0005; COGs: COG0670 Integral membrane protein interacts with FtsH; InterPro IPR006214; KEGG: dps:DP1672 hypothetical protein; PFAM: protein of unknown function UPF0005; SPTR: Conserved hypothetical membrane protein, probably cold-shock inducible; PFAM: Uncharacterised protein family UPF0005.
  
  
 0.540
secY
Protein translocase subunit secY/sec61 alpha; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
   
 
 0.537
ADW18078.1
COGs: COG0225 Peptide methionine sulfoxide reductase; InterPro IPR002569: IPR002579; KEGG: tau:Tola_0999 methionine-R-sulfoxide reductase; PFAM: Methionine sulfoxide reductase B; Methionine sulfoxide reductase A; PRIAM: Peptide-methionine (S)-S-oxide reductase., Peptide-methionine (R)-S-oxide reductase; SPTR: Methionine-R-sulfoxide reductase; TIGRFAM: methionine-R-sulfoxide reductase; peptide methionine sulfoxide reductase; PFAM: SelR domain; Peptide methionine sulfoxide reductase; TIGRFAM: methionine-S-sulfoxide reductase; methionine-R-sulfoxide reductase.
  
  
 0.528
hslU
Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
   
  
 0.522
Your Current Organism:
Desulfobulbus propionicus
NCBI taxonomy Id: 577650
Other names: D. propionicus DSM 2032, Desulfobulbus propionicus DSM 2032, Desulfobulbus propionicus str. DSM 2032, Desulfobulbus propionicus strain DSM 2032
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