STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADW16846.1Thiamine biosynthesis protein; COGs: COG0482 tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase contains the PP-loop ATPase domain; InterPro IPR020536; KEGG: dps:DP2965 hypothetical protein; PFAM: Thiamine biosynthesis protein-like; SPTR: Thiamine biosynthesis protein; PFAM: Thiamine biosynthesis protein (ThiI). (347 aa)    
Predicted Functional Partners:
rplM
LSU ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
   
 
 0.928
ADW17211.1
Sulfur relay protein, TusE/DsrC/DsvC family; COGs: COG2920 Dissimilatory sulfite reductase (desulfoviridin) gamma subunit; InterPro IPR007453; KEGG: aba:Acid345_0635 DsrC-like protein; PFAM: DsrC family protein; SPTR: DsrC-like protein; TIGRFAM: sulfur relay protein, TusE/DsrC/DsvC family; PFAM: DsrC like protein; TIGRFAM: sulfur relay protein, TusE/DsrC/DsvC family.
   
 0.919
ADW17212.1
Sulfur relay protein, TusE/DsrC/DsvC family; COGs: COG2920 Dissimilatory sulfite reductase (desulfoviridin) gamma subunit; InterPro IPR007453; KEGG: adg:Adeg_0035 sulfur relay protein, TusE/DsrC/DsvC family; PFAM: DsrC family protein; SPTR: Sulfur relay protein, TusE/DsrC/DsvC family; TIGRFAM: sulfur relay protein, TusE/DsrC/DsvC family; PFAM: DsrC like protein; TIGRFAM: sulfur relay protein, TusE/DsrC/DsvC family.
   
 0.919
rplN
LSU ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family.
   
 
 0.915
rplB
LSU ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family.
   
 
 0.911
ADW16974.1
COGs: COG0198 Ribosomal protein L24; InterPro IPR005824: IPR003256: IPR005825; KEGG: dps:DP1135 50S ribosomal protein L24; PFAM: KOW domain protein; SMART: KOW domain protein; SPTR: 50S ribosomal protein L24; TIGRFAM: ribosomal protein L24; PFAM: KOW motif; TIGRFAM: ribosomal protein L24, bacterial/organelle.
   
 
 0.911
rplK
LSU ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
   
   0.903
ADW16979.1
COGs: COG1841 Ribosomal protein L30/L7E; InterPro IPR000517: IPR005996; KEGG: dps:DP1143 50S ribosomal protein L30; PFAM: ribosomal protein L30; SPTR: 50S ribosomal protein L30; TIGRFAM: ribosomal protein L30; PFAM: Ribosomal protein L30p/L7e; TIGRFAM: ribosomal protein L30, bacterial/organelle.
    
 
 0.900
ADW19364.1
COGs: COG0482 tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase contains the PP-loop ATPase domain; InterPro IPR004506; KEGG: dak:DaAHT2_1911 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; SPTR: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; TIGRFAM: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; PFAM: tRNA methyl transferase; TIGRFAM: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase.
     
  0.900
rplE
LSU ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
  
   0.898
Your Current Organism:
Desulfobulbus propionicus
NCBI taxonomy Id: 577650
Other names: D. propionicus DSM 2032, Desulfobulbus propionicus DSM 2032, Desulfobulbus propionicus str. DSM 2032, Desulfobulbus propionicus strain DSM 2032
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