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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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ADW16850.1Crossover junction endodeoxyribonuclease RuvC; COGs: COG0817 Holliday junction resolvasome endonuclease subunit; InterPro IPR002176: IPR020563; KEGG: lpn:lpg1287 Holliday junction resolvase; PFAM: Crossover junction endodeoxyribonuclease RuvC; PRIAM: Crossover junction endodeoxyribonuclease; SPTR: Crossover junction endodeoxyribonuclease ruvC; TIGRFAM: crossover junction endodeoxyribonuclease RuvC; PFAM: Crossover junction endodeoxyribonuclease RuvC; TIGRFAM: crossover junction endodeoxyribonuclease RuvC. (162 aa)    
Predicted Functional Partners:
ADW16851.1
COGs: COG0632 Holliday junction resolvasome DNA-binding subunit; InterProIPR013849: IPR000445: IPR011114: IPR000085: IPR 003583; KEGG: dak:DaAHT2_1207 Holliday junction DNA helicase RuvA; PFAM: DNA recombination protein RuvA domain I; helix-hairpin-helix motif; RuvA domain protein; SPTR: Holliday junction DNA helicase RuvA; TIGRFAM: Holliday junction DNA helicase RuvA; manually curated; PFAM: RuvA, C-terminal domain; RuvA N terminal domain; TIGRFAM: Holliday junction DNA helicase, RuvA subunit.
 0.999
ruvB
Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
 
 0.986
ADW16849.1
Protein of unknown function DUF28; COGs: COG0217 conserved hypothetical protein; InterPro IPR002876; KEGG: dps:DP2908 hypothetical protein; PFAM: protein of unknown function DUF28; SPTR: UPF0082 protein DP2908; PFAM: Domain of unknown function DUF28; TIGRFAM: DNA-binding regulatory protein, YebC/PmpR family.
 
  
 0.837
ADW16845.1
Sigma 54 interacting domain protein; COGs: COG0497 ATPase involved in DNA repair; InterPro IPR003395: IPR004604: IPR002078; KEGG: dak:DaAHT2_0696 DNA repair protein RecN; PFAM: SMC domain protein; SPTR: DNA repair protein RecN; TIGRFAM: DNA repair protein RecN; PFAM: RecF/RecN/SMC N terminal domain; TIGRFAM: DNA repair protein RecN.
     
 0.711
ADW16923.1
COGs: COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains; InterProIPR020046: IPR020047: IPR002562: IPR001098: IPR 002298: IPR018320: IPR019760: IPR002421: IPR008918; KEGG: dak:DaAHT2_1946 DNA polymerase I; PFAM: DNA-directed DNA polymerase; 5'-3' exonuclease, N-terminal resolvase-like domain; 5'-3' exonuclease, SAM-fold domain; 3'-5' exonuclease; PRIAM: DNA-directed DNA polymerase; SMART: 5'-3' exonuclease; Helix-hairpin-helix domain protein class 2; 3'-5' exonuclease; DNA-directed DNA polymerase; SPTR: DNA polymerase A; TIGRFAM: DNA polymerase I; PFAM: 5'-3' exonuclea [...]
 
   
 0.643
ADW16848.1
COGs: COG0293 23S rRNA methylase; InterPro IPR002877: IPR016448; KEGG: dps:DP2909 ribosomal RNA methyltransferase (FtsJ); PFAM: ribosomal RNA methyltransferase RrmJ/FtsJ; SPTR: Ribosomal RNA large subunit methyltransferase E; PFAM: FtsJ-like methyltransferase; TIGRFAM: cell division protein FtsJ.
       0.640
ADW16628.1
COGs: COG0322 Nuclease subunit of the excinuclease complex; InterProIPR004791: IPR001943: IPR000305: IPR001162: IPR 000445: IPR003583; KEGG: dps:DP2478 excinuclease ABC subunit C; PFAM: excinuclease ABC C subunit domain protein; Excinuclease ABC C subunit domain protein; UvrB/UvrC protein; helix-hairpin-helix motif; SMART: Excinuclease ABC C subunit domain protein; Helix-hairpin-helix DNA-binding class 1; SPTR: UvrABC system protein C; TIGRFAM: excinuclease ABC, C subunit; manually curated; PFAM: UvrB/uvrC motif; UvrC Helix-hairpin-helix N-terminal; GIY-YIG catalytic domain; Helix-hair [...]
  
  
 0.605
ADW16847.1
Polynucleotide adenylyltransferase/metal dependent phosphohydrolase; COGs: COG0617 tRNA nucleotidyltransferase/poly(A) polymerase; InterPro IPR002646: IPR006674: IPR006675: IPR003607; KEGG: dak:DaAHT2_1316 polynucleotide adenylyltransferase/metal dependent phosphohydrolase; PFAM: Polynucleotide adenylyltransferase region; metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; SPTR: Polynucleotide adenylyltransferase/metal dependent phosphohydrolase; TIGRFAM: metal dependent phophohydrolase; PFAM: HD domain; Poly A polymerase head domain; TIGR [...]
     
 0.588
ADW16846.1
Thiamine biosynthesis protein; COGs: COG0482 tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase contains the PP-loop ATPase domain; InterPro IPR020536; KEGG: dps:DP2965 hypothetical protein; PFAM: Thiamine biosynthesis protein-like; SPTR: Thiamine biosynthesis protein; PFAM: Thiamine biosynthesis protein (ThiI).
     
 0.583
uvrA
Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
   
 
 0.564
Your Current Organism:
Desulfobulbus propionicus
NCBI taxonomy Id: 577650
Other names: D. propionicus DSM 2032, Desulfobulbus propionicus DSM 2032, Desulfobulbus propionicus str. DSM 2032, Desulfobulbus propionicus strain DSM 2032
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