STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
ADW16851.1COGs: COG0632 Holliday junction resolvasome DNA-binding subunit; InterProIPR013849: IPR000445: IPR011114: IPR000085: IPR 003583; KEGG: dak:DaAHT2_1207 Holliday junction DNA helicase RuvA; PFAM: DNA recombination protein RuvA domain I; helix-hairpin-helix motif; RuvA domain protein; SPTR: Holliday junction DNA helicase RuvA; TIGRFAM: Holliday junction DNA helicase RuvA; manually curated; PFAM: RuvA, C-terminal domain; RuvA N terminal domain; TIGRFAM: Holliday junction DNA helicase, RuvA subunit. (208 aa)    
Predicted Functional Partners:
ADW16850.1
Crossover junction endodeoxyribonuclease RuvC; COGs: COG0817 Holliday junction resolvasome endonuclease subunit; InterPro IPR002176: IPR020563; KEGG: lpn:lpg1287 Holliday junction resolvase; PFAM: Crossover junction endodeoxyribonuclease RuvC; PRIAM: Crossover junction endodeoxyribonuclease; SPTR: Crossover junction endodeoxyribonuclease ruvC; TIGRFAM: crossover junction endodeoxyribonuclease RuvC; PFAM: Crossover junction endodeoxyribonuclease RuvC; TIGRFAM: crossover junction endodeoxyribonuclease RuvC.
 0.999
ruvB
Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
 
 0.999
ADW16849.1
Protein of unknown function DUF28; COGs: COG0217 conserved hypothetical protein; InterPro IPR002876; KEGG: dps:DP2908 hypothetical protein; PFAM: protein of unknown function DUF28; SPTR: UPF0082 protein DP2908; PFAM: Domain of unknown function DUF28; TIGRFAM: DNA-binding regulatory protein, YebC/PmpR family.
   
 0.899
ADW16845.1
Sigma 54 interacting domain protein; COGs: COG0497 ATPase involved in DNA repair; InterPro IPR003395: IPR004604: IPR002078; KEGG: dak:DaAHT2_0696 DNA repair protein RecN; PFAM: SMC domain protein; SPTR: DNA repair protein RecN; TIGRFAM: DNA repair protein RecN; PFAM: RecF/RecN/SMC N terminal domain; TIGRFAM: DNA repair protein RecN.
 
  
 0.864
ADW16628.1
COGs: COG0322 Nuclease subunit of the excinuclease complex; InterProIPR004791: IPR001943: IPR000305: IPR001162: IPR 000445: IPR003583; KEGG: dps:DP2478 excinuclease ABC subunit C; PFAM: excinuclease ABC C subunit domain protein; Excinuclease ABC C subunit domain protein; UvrB/UvrC protein; helix-hairpin-helix motif; SMART: Excinuclease ABC C subunit domain protein; Helix-hairpin-helix DNA-binding class 1; SPTR: UvrABC system protein C; TIGRFAM: excinuclease ABC, C subunit; manually curated; PFAM: UvrB/uvrC motif; UvrC Helix-hairpin-helix N-terminal; GIY-YIG catalytic domain; Helix-hair [...]
  
  
 0.660
ADW18409.1
COGs: COG0556 Helicase subunit of the DNA excision repair complex; InterProIPR001943: IPR014021: IPR001650: IPR014001: IPR 004807: IPR006935; KEGG: dps:DP2765 excinuclease ABC subunit B; PFAM: helicase domain protein; type III restriction protein res subunit; UvrB/UvrC protein; SMART: DEAD-like helicase; helicase domain protein; SPTR: UvrABC system protein B; TIGRFAM: excinuclease ABC, B subunit; PFAM: Helicase conserved C-terminal domain; UvrB/uvrC motif; Type III restriction enzyme, res subunit; Ultra-violet resistance protein B; TIGRFAM: excinuclease ABC, B subunit.
  
 
 0.625
uvrA
Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
    
 0.612
ADW17589.1
COGs: COG0072 Phenylalanyl-tRNA synthetase beta subunit; InterProIPR004532: IPR002547: IPR005121: IPR005146: IPR 005147; KEGG: dps:DP1423 phenylalanyl-tRNA synthetase, beta chain; PFAM: B3/4 domain protein; t-RNA-binding domain-containing protein; tRNA synthetase B5; ferredoxin-fold anticodon-binding; SPTR: Phenylalanyl-tRNA synthetase beta chain; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; PFAM: tRNA synthetase B5 domain; B3/4 domain; Ferredoxin-fold anticodon binding domain; Putative tRNA binding domain; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bac [...]
 
   
 0.605
aspS
aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
      0.604
ADW18759.1
COGs: COG0272 NAD-dependent DNA ligase (contains BRCT domain type II); InterProIPR001679: IPR013840: IPR003583: IPR001357: IPR 018239: IPR013839: IPR004150: IPR004149: IPR000445; KEGG: dak:DaAHT2_2447 DNA ligase, NAD-dependent; PFAM: NAD-dependent DNA ligase adenylation; NAD-dependent DNA ligase OB-fold; helix-hairpin-helix motif; BRCT domain protein; PRIAM: DNA ligase (NAD(+)); SMART: NAD-dependent DNA ligase; Helix-hairpin-helix DNA-binding class 1; BRCT domain protein; SPTR: DNA ligase, NAD-dependent; TIGRFAM: DNA ligase, NAD-dependent; PFAM: NAD-dependent DNA ligase OB-fold domain; [...]
  
   
 0.602
Your Current Organism:
Desulfobulbus propionicus
NCBI taxonomy Id: 577650
Other names: D. propionicus DSM 2032, Desulfobulbus propionicus DSM 2032, Desulfobulbus propionicus str. DSM 2032, Desulfobulbus propionicus strain DSM 2032
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