Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ADW16940.1COGs: COG0307 Riboflavin synthase alpha chain; InterPro IPR001783; KEGG: dak:DaAHT2_1278 riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; PRIAM: Riboflavin synthase; SPTR: Lumazine-binding protein; TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine binding domain; TIGRFAM: riboflavin synthase, alpha subunit. (217 aa)    
Predicted Functional Partners:
ribBA
GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
 
 0.999
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
 
 0.999
ADW18154.1
COGs: COG0117 Pyrimidine deaminase; InterProIPR016192: IPR004794: IPR011549: IPR002125: IPR 002734; KEGG: dak:DaAHT2_1279 riboflavin biosynthesis protein RibD; PFAM: bifunctional deaminase-reductase domain protein; CMP/dCMP deaminase zinc-binding; SPTR: Riboflavin biosynthesis protein RibD; TIGRFAM: riboflavin biosynthesis protein RibD; PFAM: RibD C-terminal domain; Cytidine and deoxycytidylate deaminase zinc-binding region; TIGRFAM: riboflavin-specific deaminase C-terminal domain; riboflavin biosynthesis protein RibD.
  
 0.999
ADW18080.1
COGs: COG0108 3 4-dihydroxy-2-butanone 4-phosphate synthase; InterPro IPR000422; KEGG: hch:HCH_01388 3,4-dihydroxy-2-butanone 4-phosphate synthase; PFAM: 34-dihydroxy-2-butanone 4-phosphate synthase; SPTR: 3,4-dihydroxy-2-butanone 4-phosphate synthase; TIGRFAM: 3,4-dihydroxy-2-butanone 4-phosphate synthase; PFAM: 3,4-dihydroxy-2-butanone 4-phosphate synthase; TIGRFAM: 3,4-dihydroxy-2-butanone 4-phosphate synthase.
  
 0.997
ADW16936.1
FMN adenylyltransferase; COGs: COG0196 FAD synthase; InterPro IPR015864: IPR015865: IPR002606: IPR022272; KEGG: dak:DaAHT2_1659 riboflavin biosynthesis protein RibF; PFAM: FAD synthetase; Riboflavin kinase; SPTR: Riboflavin biosynthesis protein RibF; TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: Riboflavin kinase; FAD synthetase; TIGRFAM: riboflavin kinase/FMN adenylyltransferase.
    
 0.965
ADW16939.1
Hypothetical protein; InterPro IPR019734: IPR013026; KEGG: dps:DP1098 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.796
ADW16938.1
KEGG: dak:DaAHT2_1673 heat repeat-containing PBS lyase; SPTR: Heat repeat-containing PBS lyase.
       0.794
ADW16937.1
Tetratricopeptide TPR_1 repeat-containing protein; InterPro IPR001440: IPR006597: IPR019734: IPR013026; KEGG: dps:DP1095 hypothetical protein; PFAM: Tetratricopeptide TPR_1 repeat-containing protein; Sel1 domain protein repeat-containing protein; SMART: Tetratricopeptide repeat; SPTR: Putative uncharacterized protein; PFAM: Tetratricopeptide repeat.
       0.793
ADW16943.1
NusB antitermination factor; COGs: COG0781 Transcription termination factor; InterPro IPR006027: IPR011605; KEGG: dps:DP1102 transcription termination factor (NusB); PFAM: NusB/RsmB/TIM44; SPTR: N utilization substance protein B homolog; TIGRFAM: transcription antitermination factor NusB; PFAM: NusB family; TIGRFAM: transcription antitermination factor NusB.
       0.516
ADW17034.1
NH(3)-dependent NAD(+) synthetase; COGs: COG0171 NAD synthase; InterPro IPR003010: IPR003694: IPR014445; KEGG: dps:DP2919 glutamine-dependent NAD(+) synthetase; PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; SPTR: Probable glutamine-dependent NAD(+) synthetase; TIGRFAM: NAD+ synthetase; PFAM: NAD synthase; Carbon-nitrogen hydrolase; TIGRFAM: NAD+ synthetase.
  
  
 0.445
Your Current Organism:
Desulfobulbus propionicus
NCBI taxonomy Id: 577650
Other names: D. propionicus DSM 2032, Desulfobulbus propionicus DSM 2032, Desulfobulbus propionicus str. DSM 2032, Desulfobulbus propionicus strain DSM 2032
Server load: low (16%) [HD]