STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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ispG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (361 aa)    
Predicted Functional Partners:
ADW18853.1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; COGs: COG1211 4-diphosphocytidyl-2-methyl-D-erithritol synthase; InterPro IPR003526: IPR001228: IPR018294: IPR020555; KEGG: dps:DP0257 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; PFAM: MECDP-synthase; 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; SPTR: Bifunctional enzyme ispD/ispF; TIGRFAM: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; PFAM: YgbB family; Uncharacterized pr [...]
 
  
 0.991
ADW18722.1
4-hydroxy-3-methylbut-2-enyl diphosphate reductase; COGs: COG0761 Penicillin tolerance protein; InterPro IPR003451; KEGG: acr:Acry_1832 hydroxymethylbutenyl pyrophosphate reductase; PFAM: LytB protein; PRIAM: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; SPTR: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; TIGRFAM: hydroxymethylbutenyl pyrophosphate reductase; PFAM: LytB protein; TIGRFAM: (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming).
 
 
 0.985
ADW16996.1
COGs: COG0743 1-deoxy-D-xylulose 5-phosphate reductoisomerase; InterPro IPR013512: IPR013644: IPR003821; KEGG: dps:DP1160 1-deoxy-D-xylulose 5-phosphate reductoisomerase; PFAM: 1-deoxy-D-xylulose 5-phosphate reductoisomerase domain-containing protein; PRIAM: 1-deoxy-D-xylulose-5-phosphate reductoisomerase; SPTR: 1-deoxy-D-xylulose 5-phosphate reductoisomerase; TIGRFAM: 1-deoxy-D-xylulose 5-phosphate reductoisomerase; PFAM: 1-deoxy-D-xylulose 5-phosphate reductoisomerase; 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; TIGRFAM: 1-deoxy-D-xylulose 5-phosphate reductoisomerase.
 
   
 0.931
ADW18909.1
COGs: COG0124 Histidyl-tRNA synthetase; InterProIPR006195: IPR002314: IPR004154: IPR004516: IPR 015807; KEGG: dps:DP0571 histidyl-tRNA synthetase; PFAM: tRNA synthetase class II (G H P and S); Anticodon-binding domain protein; PRIAM: Histidine--tRNA ligase; SPTR: Histidyl-tRNA synthetase; TIGRFAM: histidyl-tRNA synthetase; PFAM: Anticodon binding domain; tRNA synthetase class II core domain (G, H, P, S and T); TIGRFAM: histidyl-tRNA synthetase.
  
  
 0.843
ADW18547.1
COGs: COG1154 Deoxyxylulose-5-phosphate synthase; InterPro IPR005477: IPR005475: IPR005476: IPR020826; KEGG: dps:DP2700 1-deoxy-D-xylulose-5-phosphate synthase; PFAM: Transketolase central region; Transketolase domain-containing protein; SPTR: 1-deoxy-D-xylulose-5-phosphate synthase; TIGRFAM: deoxyxylulose-5-phosphate synthase; PFAM: Transketolase, C-terminal domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Transketolase, pyrimidine binding domain; TIGRFAM: 1-deoxy-D-xylulose-5-phosphate synthase.
 
   
 0.828
ADW18622.1
4-diphosphocytidyl-2C-methyl-D-erythritolkinase; COGs: COG1947 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase; InterPro IPR004424: IPR006204: IPR013750; KEGG: sat:SYN_03046 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; PFAM: GHMP kinase; GHMP kinase domain protein; SPTR: 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; TIGRFAM: 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; PFAM: GHMP kinases C terminal; GHMP kinases N terminal domain; TIGRFAM: 4-diphosphocytidyl-2C-methyl-D-erythritol kinase.
 
   
 0.816
ADW16997.1
Site-2 protease; COGs: COG0750 membrane-associated Zn-dependent protease 1; InterPro IPR008915: IPR001478: IPR004387; KEGG: dak:DaAHT2_0974 membrane-associated zinc metalloprotease; PFAM: peptidase M50; PDZ/DHR/GLGF domain protein; SMART: PDZ/DHR/GLGF domain protein; SPTR: Membrane-associated zinc metalloprotease; TIGRFAM: membrane-associated zinc metalloprotease; PFAM: Peptidase family M50; PDZ domain (Also known as DHR or GLGF); TIGRFAM: RIP metalloprotease RseP.
       0.762
ADW16998.1
Peptidase M22 glycoprotease; COGs: COG1214 Inactive homolog of metal-dependent protease putative molecular chaperone; InterPro IPR000905: IPR017861; KEGG: dps:DP1162 glycoprotein endopeptidase; PFAM: peptidase M22 glycoprotease; SPTR: Related to glycoprotein endopeptidase; PFAM: Glycoprotease family; TIGRFAM: universal bacterial protein YeaZ.
       0.762
ADW18751.1
Transcriptional regulator, XRE family; COGs: COG1426 conserved hypothetical protein; InterPro IPR001387; KEGG: dps:DP3085 hypothetical protein; PFAM: helix-turn-helix domain protein; SMART: helix-turn-helix domain protein; SPTR: Helix-turn-helix motif; PFAM: Helix-turn-helix.
  
    0.749
ADW16994.1
COGs: COG0020 Undecaprenyl pyrophosphate synthase; InterPro IPR001441: IPR018520; KEGG: dps:DP1158 undecaprenyl pyrophosphate synthetase; PFAM: Di-trans-poly-cis-decaprenylcistransferase; PRIAM: Di-trans,poly-cis-decaprenylcistransferase; SPTR: Probable undecaprenyl pyrophosphate synthetase; TIGRFAM: undecaprenyl diphosphate synthase; PFAM: Putative undecaprenyl diphosphate synthase; TIGRFAM: undecaprenyl diphosphate synthase.
  
  
 0.680
Your Current Organism:
Desulfobulbus propionicus
NCBI taxonomy Id: 577650
Other names: D. propionicus DSM 2032, Desulfobulbus propionicus DSM 2032, Desulfobulbus propionicus str. DSM 2032, Desulfobulbus propionicus strain DSM 2032
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