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glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (416 aa)    
Predicted Functional Partners:
ADW18869.1
COGs: COG0404 Glycine cleavage system T protein (aminomethyltransferase); InterPro IPR006222; KEGG: dps:DP0301 glycine cleavage system, T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); SPTR: Related to glycine cleavage system, T protein; PFAM: Aminomethyltransferase folate-binding domain.
 
 0.998
ADW18866.1
Glycine dehydrogenase (decarboxylating) beta subunit; COGs: COG1003 Glycine cleavage system protein P (pyridoxal-binding) C-terminal domain; InterPro IPR020580; KEGG: dps:DP0298 glycine dehydrogenase subunit 2; PFAM: Glycine cleavage system P-protein-like; SPTR: Probable glycine dehydrogenase, subunit 2; PFAM: Glycine cleavage system P-protein.
 
 
 0.988
folD
5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
  
 0.986
ADW18740.1
Phosphoribosylaminoimidazolecarboxamide formyltransferase; COGs: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); InterPro IPR002695: IPR013982; KEGG: dak:DaAHT2_1420 IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme formylation region; PRIAM: Phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme formylation region; SPTR: IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme.
  
 0.985
ADW18868.1
COGs: COG0509 Glycine cleavage system H protein (lipoate-binding); InterPro IPR002930: IPR017453: IPR003016; KEGG: dps:DP0300 glycine cleavage system, H protein; PFAM: glycine cleavage H-protein; SPTR: Glycine cleavage system H protein; TIGRFAM: glycine cleavage system H protein; PFAM: Glycine cleavage H-protein; TIGRFAM: glycine cleavage system H protein.
  
 
 0.981
ADW18867.1
Glycine dehydrogenase (decarboxylating) alpha subunit; COGs: COG0403 Glycine cleavage system protein P (pyridoxal-binding) N-terminal domain; InterPro IPR020580; KEGG: dps:DP0299 glycine dehydrogenase subunit 1; PFAM: Glycine cleavage system P-protein-like; PRIAM: Glycine dehydrogenase (decarboxylating); SPTR: Probable glycine dehydrogenase [decarboxylating] subunit 1; PFAM: Glycine cleavage system P-protein.
 
 
 0.976
ADW18960.1
Formyl transferase domain protein; COGs: COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN; InterPro IPR002376: IPR001555; KEGG: dps:DP1615 phosphoribosylglycinamide formyltransferase; PFAM: formyl transferase domain protein; SPTR: Related to phosphoribosylglycinamide formyltransferase; PFAM: Formyl transferase.
  
 0.976
ADW19128.1
COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterProIPR013027: IPR004099: IPR000815: IPR012999: IPR 006258; KEGG: alv:Alvin_0803 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; SPTR: Dihydrolipoyl dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase.
  
 
 0.966
ADW16679.1
COGs: COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain; InterPro IPR017926: IPR010073: IPR000728: IPR010918; KEGG: dps:DP0704 phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein; PRIAM: Phosphoribosylformylglycinamidine synthase; SPTR: Probable phosphoribosylformylglycinamidine synthase; TIGRFAM: phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: phosphoribosylformylglycinamidine synt [...]
  
  
 0.956
ADW19374.1
COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: dsa:Desal_2300 methylenetetrahydrofolate reductase (NAD(P)H); PFAM: methylenetetrahydrofolate reductase; PRIAM: Methylenetetrahydrofolate reductase (NAD(P)H); SPTR: Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase.
  
 
 0.955
Your Current Organism:
Desulfobulbus propionicus
NCBI taxonomy Id: 577650
Other names: D. propionicus DSM 2032, Desulfobulbus propionicus DSM 2032, Desulfobulbus propionicus str. DSM 2032, Desulfobulbus propionicus strain DSM 2032
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