Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ADW17136.1Porphobilinogen synthase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731; KEGG: dps:DP2824 delta-aminolevulinic acid dehydratase; PFAM: delta-aminolevulinic acid dehydratase; PRIAM: Porphobilinogen synthase; SPTR: Delta-aminolevulinic acid dehydratase; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (326 aa)    
Predicted Functional Partners:
ADW18711.1
Hydroxymethylbilane synthase; COGs: COG0181 Porphobilinogen deaminase; InterPro IPR000860; KEGG: dak:DaAHT2_0535 porphobilinogen deaminase; PFAM: Porphobilinogen deaminase; SPTR: Porphobilinogen deaminase; TIGRFAM: porphobilinogen deaminase; PFAM: Porphobilinogen deaminase, C-terminal domain; Porphobilinogen deaminase, dipyromethane cofactor binding domain; TIGRFAM: porphobilinogen deaminase.
 
 0.997
cobA
COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR006366: IPR003043: IPR000878: IPR003754; KEGG: dps:DP1734 uroporphyrinogen III synthase/methyltransferase (HemD+CobA); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; SPTR: Probable uroporphyrinogen III synthase/methyltransferase (HemD+CobA); TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; Uroporphyrinogen-III synthase HemD; TIGRFAM: uroporphyrin-III C-methyltransferase.
 
 0.996
hemL
COGs: COG0001 Glutamate-1-semialdehyde aminotransferase; InterPro IPR005814: IPR004639; KEGG: dps:DP0812 glutamate-1-semialdehyde 2,1-aminomutase; PFAM: aminotransferase class-III; SPTR: Glutamate-1-semialdehyde 2,1-aminomutase; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: Aminotransferase class-III; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase.
 
 
 0.994
ADW18743.1
COGs: COG0373 Glutamyl-tRNA reductase; InterProIPR000343: IPR018214: IPR015895: IPR006151: IPR 015896; KEGG: dps:DP3079 glutamyl-tRNA reductase; PFAM: Shikimate/quinate 5-dehydrogenase; Tetrapyrrole biosynthesis, glutamyl-tRNA reductase-like; SPTR: Glutamyl-tRNA reductase; TIGRFAM: glutamyl-tRNA reductase; PFAM: Shikimate / quinate 5-dehydrogenase; Glutamyl-tRNAGlu reductase, N-terminal domain; Glutamyl-tRNAGlu reductase, dimerisation domain; TIGRFAM: glutamyl-tRNA reductase.
 
  
 0.876
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 
 0.840
ADW18745.1
COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR006367; KEGG: dak:DaAHT2_2550 siroheme synthase; SPTR: Siroheme synthase; TIGRFAM: siroheme synthase; TIGRFAM: siroheme synthase, N-terminal domain.
 
   
 0.671
ADW16925.1
Ferrochelatase; COGs: COG0276 Protoheme ferro-lyase (ferrochelatase); InterPro IPR001015: IPR019772; KEGG: dps:DP1085 ferrochelatase; PFAM: ferrochelatase; SPTR: Ferrochelatase; TIGRFAM: ferrochelatase; PFAM: Ferrochelatase; TIGRFAM: ferrochelatase.
 
  
 0.625
ribBA
GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
  
  
 0.582
ADW18154.1
COGs: COG0117 Pyrimidine deaminase; InterProIPR016192: IPR004794: IPR011549: IPR002125: IPR 002734; KEGG: dak:DaAHT2_1279 riboflavin biosynthesis protein RibD; PFAM: bifunctional deaminase-reductase domain protein; CMP/dCMP deaminase zinc-binding; SPTR: Riboflavin biosynthesis protein RibD; TIGRFAM: riboflavin biosynthesis protein RibD; PFAM: RibD C-terminal domain; Cytidine and deoxycytidylate deaminase zinc-binding region; TIGRFAM: riboflavin-specific deaminase C-terminal domain; riboflavin biosynthesis protein RibD.
     
 0.573
ADW19153.1
COGs: COG2875 Precorrin-4 methylase; InterPro IPR000878: IPR003043: IPR006362; KEGG: dps:DP0222 precorrin-4 C11-methyltransferase (CobM); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-4 C(11)-methyltransferase; SPTR: Probable precorrin-4 C11-methyltransferase (CobM); TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-4 C11-methyltransferase.
 
   
 0.573
Your Current Organism:
Desulfobulbus propionicus
NCBI taxonomy Id: 577650
Other names: D. propionicus DSM 2032, Desulfobulbus propionicus DSM 2032, Desulfobulbus propionicus str. DSM 2032, Desulfobulbus propionicus strain DSM 2032
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.