Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
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ADW17537.1COGs: COG0337 3-dehydroquinate synthetase; InterPro IPR016037: IPR016303: IPR002658; KEGG: dak:DaAHT2_0294 3-dehydroquinate synthase; PFAM: 3-dehydroquinate synthase; PRIAM: 3-dehydroquinate synthase; SPTR: 3-dehydroquinate synthase; TIGRFAM: 3-dehydroquinate synthase; PFAM: 3-dehydroquinate synthase; TIGRFAM: 3-dehydroquinate synthase. (360 aa)    
Predicted Functional Partners:
ADW19107.1
COGs: COG0703 Shikimate kinase; InterPro IPR000623; KEGG: dak:DaAHT2_2092 shikimate kinase; PFAM: shikimate kinase; PRIAM: Shikimate kinase; SPTR: Shikimate kinase; PFAM: Shikimate kinase.
  
 0.997
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
  
 0.988
ADW16473.1
3-phosphoshikimate 1-carboxyvinyltransferase; COGs: COG0128 5-enolpyruvylshikimate-3-phosphate synthase; InterPro IPR001986: IPR006264: IPR016228; KEGG: dak:DaAHT2_0008 3-phosphoshikimate 1-carboxyvinyltransferase; PFAM: EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); SPTR: 3-phosphoshikimate 1-carboxyvinyltransferase; TIGRFAM: 3-phosphoshikimate 1-carboxyvinyltransferase; PFAM: EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); TIGRFAM: 3-phosphoshikimate 1-carboxyvinyltransferase.
  
 0.987
ADW16474.1
COGs: COG0169 Shikimate 5-dehydrogenase; InterPro IPR011342: IPR013708: IPR006151; KEGG: dak:DaAHT2_0009 shikimate 5-dehydrogenase; PFAM: Shikimate dehydrogenase substrate binding domain protein; Shikimate/quinate 5-dehydrogenase; SPTR: Shikimate 5-dehydrogenase; TIGRFAM: shikimate 5-dehydrogenase; PFAM: Shikimate dehydrogenase substrate binding domain; Shikimate / quinate 5-dehydrogenase; TIGRFAM: shikimate 5-dehydrogenase.
  
 0.986
ADW16475.1
COGs: COG0710 3-dehydroquinate dehydratase; InterPro IPR001381; KEGG: dps:DP3013 3-dehydroquinate dehydratase; PFAM: dehydroquinase class I; PRIAM: 3-dehydroquinate dehydratase; SPTR: 3-dehydroquinate dehydratase; TIGRFAM: 3-dehydroquinate dehydratase, type I; PFAM: Type I 3-dehydroquinase; TIGRFAM: 3-dehydroquinate dehydratase, type I.
 
 
 0.957
ADW16689.1
COGs: COG3200 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; InterPro IPR002480; KEGG: dat:HRM2_09580 AroH; PFAM: DAHP synthetase class II; PRIAM: 3-deoxy-7-phosphoheptulonate synthase; SPTR: Probable phospho-2-dehydro-3-deoxyheptonate aldolase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; manually curated; PFAM: Class-II DAHP synthetase family; TIGRFAM: 3-deoxy-7-phosphoheptulonate synthase, class II.
 
  
 0.946
ADW17294.1
COGs: COG0703 Shikimate kinase; InterPro IPR000623; KEGG: glo:Glov_3097 shikimate kinase; PFAM: shikimate kinase; SPTR: Shikimate kinase; PFAM: Shikimate kinase.
 
  
 0.918
ADW18324.1
COGs: COG0077 Prephenate dehydratase; InterPro IPR001086: IPR003099: IPR002912; KEGG: dps:DP2275 P-protein; PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; Prephenate dehydrogenase; SPTR: Related to P-protein; PFAM: Prephenate dehydratase; Prephenate dehydrogenase; ACT domain.
  
  
 0.881
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
 
  
 0.770
smpB
SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...]
  
    0.739
Your Current Organism:
Desulfobulbus propionicus
NCBI taxonomy Id: 577650
Other names: D. propionicus DSM 2032, Desulfobulbus propionicus DSM 2032, Desulfobulbus propionicus str. DSM 2032, Desulfobulbus propionicus strain DSM 2032
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