close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADW17537.1COGs: COG0337 3-dehydroquinate synthetase; InterPro IPR016037: IPR016303: IPR002658; KEGG: dak:DaAHT2_0294 3-dehydroquinate synthase; PFAM: 3-dehydroquinate synthase; PRIAM: 3-dehydroquinate synthase; SPTR: 3-dehydroquinate synthase; TIGRFAM: 3-dehydroquinate synthase; PFAM: 3-dehydroquinate synthase; TIGRFAM: 3-dehydroquinate synthase. (360 aa)    
Predicted Functional Partners:
ADW19107.1
COGs: COG0703 Shikimate kinase; InterPro IPR000623; KEGG: dak:DaAHT2_2092 shikimate kinase; PFAM: shikimate kinase; PRIAM: Shikimate kinase; SPTR: Shikimate kinase; PFAM: Shikimate kinase.
  
 0.996
ADW16473.1
3-phosphoshikimate 1-carboxyvinyltransferase; COGs: COG0128 5-enolpyruvylshikimate-3-phosphate synthase; InterPro IPR001986: IPR006264: IPR016228; KEGG: dak:DaAHT2_0008 3-phosphoshikimate 1-carboxyvinyltransferase; PFAM: EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); SPTR: 3-phosphoshikimate 1-carboxyvinyltransferase; TIGRFAM: 3-phosphoshikimate 1-carboxyvinyltransferase; PFAM: EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); TIGRFAM: 3-phosphoshikimate 1-carboxyvinyltransferase.
  
 0.994
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
  
 0.988
ADW16474.1
COGs: COG0169 Shikimate 5-dehydrogenase; InterPro IPR011342: IPR013708: IPR006151; KEGG: dak:DaAHT2_0009 shikimate 5-dehydrogenase; PFAM: Shikimate dehydrogenase substrate binding domain protein; Shikimate/quinate 5-dehydrogenase; SPTR: Shikimate 5-dehydrogenase; TIGRFAM: shikimate 5-dehydrogenase; PFAM: Shikimate dehydrogenase substrate binding domain; Shikimate / quinate 5-dehydrogenase; TIGRFAM: shikimate 5-dehydrogenase.
  
 0.985
ADW16475.1
COGs: COG0710 3-dehydroquinate dehydratase; InterPro IPR001381; KEGG: dps:DP3013 3-dehydroquinate dehydratase; PFAM: dehydroquinase class I; PRIAM: 3-dehydroquinate dehydratase; SPTR: 3-dehydroquinate dehydratase; TIGRFAM: 3-dehydroquinate dehydratase, type I; PFAM: Type I 3-dehydroquinase; TIGRFAM: 3-dehydroquinate dehydratase, type I.
 
 
 0.954
ADW16689.1
COGs: COG3200 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; InterPro IPR002480; KEGG: dat:HRM2_09580 AroH; PFAM: DAHP synthetase class II; PRIAM: 3-deoxy-7-phosphoheptulonate synthase; SPTR: Probable phospho-2-dehydro-3-deoxyheptonate aldolase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; manually curated; PFAM: Class-II DAHP synthetase family; TIGRFAM: 3-deoxy-7-phosphoheptulonate synthase, class II.
 
  
 0.943
ADW17294.1
COGs: COG0703 Shikimate kinase; InterPro IPR000623; KEGG: glo:Glov_3097 shikimate kinase; PFAM: shikimate kinase; SPTR: Shikimate kinase; PFAM: Shikimate kinase.
 
  
 0.915
ADW18324.1
COGs: COG0077 Prephenate dehydratase; InterPro IPR001086: IPR003099: IPR002912; KEGG: dps:DP2275 P-protein; PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; Prephenate dehydrogenase; SPTR: Related to P-protein; PFAM: Prephenate dehydratase; Prephenate dehydrogenase; ACT domain.
  
  
 0.886
smpB
SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...]
  
    0.783
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
 
  
 0.751
Your Current Organism:
Desulfobulbus propionicus
NCBI taxonomy Id: 577650
Other names: D. propionicus DSM 2032, Desulfobulbus propionicus DSM 2032, Desulfobulbus propionicus str. DSM 2032, Desulfobulbus propionicus strain DSM 2032
Server load: medium (50%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.