STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADW17674.1Abortive phage infection; InterPro IPR018891; KEGG: neu:NE0489 abortive infection phage resistance protein; PFAM: Abortive phage infection; SPTR: Possible abortive infection phage resistance protein; PFAM: AIPR protein. (560 aa)    
Predicted Functional Partners:
ADW17673.1
COGs: COG0188 Type IIA topoisomerase (DNA gyrase/topo II topoisomerase IV) A subunit; InterPro IPR002205; KEGG: dps:DP2281 DNA topoisomerase IV subunit A; PFAM: DNA gyrase/topoisomerase IV subunit A; PRIAM: DNA topoisomerase (ATP-hydrolyzing); SMART: DNA gyrase/topoisomerase IV subunit A; SPTR: Probable topoisomerase IV, subunit A; PFAM: DNA gyrase/topoisomerase IV, subunit A.
  
 
 0.985
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
  
 
 0.973
ADW17332.1
HRDC domain protein; COGs: COG0507 ATP-dependent exoDNAse (exonuclease V) alpha subunit - helicase superfamily I member; InterPro IPR002121; KEGG: dat:HRM2_02150 helicase-family protein; PFAM: HRDC domain protein; SMART: HRDC domain protein; SPTR: Helicase-family protein; PFAM: PIF1 helicase; HRDC domain.
 
 
 0.804
ADW19079.1
Hypothetical protein; InterPro IPR000608: IPR019734; KEGG: dps:DP0803 hypothetical protein; SPTR: Putative uncharacterized protein.
   
 0.802
ADW17675.1
COGs: COG0123 Deacetylase including yeast histone deacetylase and acetoin utilization protein; InterPro IPR000286; KEGG: dak:DaAHT2_2668 histone deacetylase; PFAM: histone deacetylase superfamily; SPTR: Histone deacetylase superfamily; PFAM: Histone deacetylase domain.
  
 
 0.721
ADW17148.1
OmpA/MotB domain protein; COGs: COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)protein; InterPro IPR006664: IPR006665; KEGG: lif:LinJ14.1210 kinesin K39; PFAM: OmpA/MotB domain protein; SPTR: Kinesin K39, putative; PFAM: OmpA family.
  
 
 0.675
ADW16599.1
Protein of unknown function DUF891; COGs: COG4679 Phage-related protein; InterPro IPR009241; KEGG: xfn:XfasM23_1023 hypothetical protein; PFAM: protein of unknown function DUF891; SPTR: Phage-related protein; manually curated; PFAM: Phage derived protein Gp49-like (DUF891).
  
   
 0.648
ADW18544.1
Pentapeptide repeat protein; COGs: COG1357 Uncharacterized low-complexity protein; InterPro IPR001646; KEGG: amr:AM1_B0195 pentapeptide repeat-containing protein; PFAM: pentapeptide repeat protein; SPTR: Pentapeptide repeat family protein; PFAM: Pentapeptide repeats (8 copies).
  
 
 
 0.636
ADW16923.1
COGs: COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains; InterProIPR020046: IPR020047: IPR002562: IPR001098: IPR 002298: IPR018320: IPR019760: IPR002421: IPR008918; KEGG: dak:DaAHT2_1946 DNA polymerase I; PFAM: DNA-directed DNA polymerase; 5'-3' exonuclease, N-terminal resolvase-like domain; 5'-3' exonuclease, SAM-fold domain; 3'-5' exonuclease; PRIAM: DNA-directed DNA polymerase; SMART: 5'-3' exonuclease; Helix-hairpin-helix domain protein class 2; 3'-5' exonuclease; DNA-directed DNA polymerase; SPTR: DNA polymerase A; TIGRFAM: DNA polymerase I; PFAM: 5'-3' exonuclea [...]
  
 
 0.622
ADW19417.1
COGs: COG0592 DNA polymerase sliding clamp subunit (PCNA homolog); InterPro IPR001001; KEGG: dps:DP0648 DNA polymerase III, beta chain; PFAM: DNA polymerase III beta chain; PRIAM: DNA-directed DNA polymerase; SMART: DNA polymerase III beta chain; SPTR: Probable DNA polymerase III, beta chain; TIGRFAM: DNA polymerase III, beta subunit; PFAM: DNA polymerase III beta subunit, C-terminal domain; DNA polymerase III beta subunit, N-terminal domain; DNA polymerase III beta subunit, central domain; TIGRFAM: DNA polymerase III, beta subunit.
  
 
 0.614
Your Current Organism:
Desulfobulbus propionicus
NCBI taxonomy Id: 577650
Other names: D. propionicus DSM 2032, Desulfobulbus propionicus DSM 2032, Desulfobulbus propionicus str. DSM 2032, Desulfobulbus propionicus strain DSM 2032
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.