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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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ADW17718.1UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR000212: IPR014016: IPR014017; KEGG: dps:DP2879 ATP-dependent DNA helicase UvrD; PFAM: UvrD/REP helicase; SPTR: Probable ATP-dependent DNA helicase, UvrD/REP family; PFAM: UvrD/REP helicase. (731 aa)    
Predicted Functional Partners:
ADW17332.1
HRDC domain protein; COGs: COG0507 ATP-dependent exoDNAse (exonuclease V) alpha subunit - helicase superfamily I member; InterPro IPR002121; KEGG: dat:HRM2_02150 helicase-family protein; PFAM: HRDC domain protein; SMART: HRDC domain protein; SPTR: Helicase-family protein; PFAM: PIF1 helicase; HRDC domain.
  
 
 0.942
ADW19417.1
COGs: COG0592 DNA polymerase sliding clamp subunit (PCNA homolog); InterPro IPR001001; KEGG: dps:DP0648 DNA polymerase III, beta chain; PFAM: DNA polymerase III beta chain; PRIAM: DNA-directed DNA polymerase; SMART: DNA polymerase III beta chain; SPTR: Probable DNA polymerase III, beta chain; TIGRFAM: DNA polymerase III, beta subunit; PFAM: DNA polymerase III beta subunit, C-terminal domain; DNA polymerase III beta subunit, N-terminal domain; DNA polymerase III beta subunit, central domain; TIGRFAM: DNA polymerase III, beta subunit.
 
 
 0.884
ADW17080.1
COGs: COG0323 DNA mismatch repair enzyme (predicted ATPase); InterProIPR003594: IPR013507: IPR014790: IPR020667: IPR 014763; KEGG: dak:DaAHT2_1338 DNA mismatch repair protein MutL; PFAM: MutL dimerisation; DNA mismatch repair protein domain protein; ATP-binding region ATPase domain protein; SPTR: DNA mismatch repair protein MutL; TIGRFAM: DNA mismatch repair protein MutL; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; MutL C terminal dimerisation domain; DNA mismatch repair protein, C-terminal domain; TIGRFAM: DNA mismatch repair protein MutL.
  
 
 0.864
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.855
ADW16923.1
COGs: COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains; InterProIPR020046: IPR020047: IPR002562: IPR001098: IPR 002298: IPR018320: IPR019760: IPR002421: IPR008918; KEGG: dak:DaAHT2_1946 DNA polymerase I; PFAM: DNA-directed DNA polymerase; 5'-3' exonuclease, N-terminal resolvase-like domain; 5'-3' exonuclease, SAM-fold domain; 3'-5' exonuclease; PRIAM: DNA-directed DNA polymerase; SMART: 5'-3' exonuclease; Helix-hairpin-helix domain protein class 2; 3'-5' exonuclease; DNA-directed DNA polymerase; SPTR: DNA polymerase A; TIGRFAM: DNA polymerase I; PFAM: 5'-3' exonuclea [...]
  
 
 0.839
ADW16628.1
COGs: COG0322 Nuclease subunit of the excinuclease complex; InterProIPR004791: IPR001943: IPR000305: IPR001162: IPR 000445: IPR003583; KEGG: dps:DP2478 excinuclease ABC subunit C; PFAM: excinuclease ABC C subunit domain protein; Excinuclease ABC C subunit domain protein; UvrB/UvrC protein; helix-hairpin-helix motif; SMART: Excinuclease ABC C subunit domain protein; Helix-hairpin-helix DNA-binding class 1; SPTR: UvrABC system protein C; TIGRFAM: excinuclease ABC, C subunit; manually curated; PFAM: UvrB/uvrC motif; UvrC Helix-hairpin-helix N-terminal; GIY-YIG catalytic domain; Helix-hair [...]
 
  
 0.821
ADW18759.1
COGs: COG0272 NAD-dependent DNA ligase (contains BRCT domain type II); InterProIPR001679: IPR013840: IPR003583: IPR001357: IPR 018239: IPR013839: IPR004150: IPR004149: IPR000445; KEGG: dak:DaAHT2_2447 DNA ligase, NAD-dependent; PFAM: NAD-dependent DNA ligase adenylation; NAD-dependent DNA ligase OB-fold; helix-hairpin-helix motif; BRCT domain protein; PRIAM: DNA ligase (NAD(+)); SMART: NAD-dependent DNA ligase; Helix-hairpin-helix DNA-binding class 1; BRCT domain protein; SPTR: DNA ligase, NAD-dependent; TIGRFAM: DNA ligase, NAD-dependent; PFAM: NAD-dependent DNA ligase OB-fold domain; [...]
  
  
 0.797
ADW17061.1
DNA topoisomerase III; COGs: COG0550 Topoisomerase IA; InterProIPR006171: IPR013497: IPR000380: IPR005738: IPR 006154: IPR003601: IPR003602; KEGG: dps:DP2617 DNA topoisomerase III; PFAM: DNA topoisomerase type IA central domain protein; TOPRIM domain-containing protein; SMART: DNA topoisomerase I DNA-binding; DNA topoisomerase I ATP-binding; Toprim sub domain-containing protein; SPTR: DNA topoisomerase; TIGRFAM: DNA topoisomerase III; PFAM: Toprim domain; DNA topoisomerase; TIGRFAM: DNA topoisomerase III, bacteria and conjugative plasmid.
  
 
 0.786
rpoB
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.776
ADW19357.1
COGs: COG0420 DNA repair exonuclease; InterPro IPR004843: IPR004593; KEGG: gur:Gura_1979 nuclease SbcCD, D subunit; PFAM: metallophosphoesterase; SPTR: Exodeoxyribonuclease I subunit D; TIGRFAM: nuclease SbcCD, D subunit; PFAM: Calcineurin-like phosphoesterase; Type 5 capsule protein repressor C terminal; TIGRFAM: exonuclease SbcD.
   
 
 0.774
Your Current Organism:
Desulfobulbus propionicus
NCBI taxonomy Id: 577650
Other names: D. propionicus DSM 2032, Desulfobulbus propionicus DSM 2032, Desulfobulbus propionicus str. DSM 2032, Desulfobulbus propionicus strain DSM 2032
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