Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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ADW17815.1Gliding motility protein (MglA); COGs: COG2229 GTPase; InterPro IPR001806; KEGG: dps:DP2776 gliding motility protein (MglA); SPTR: Probable gliding motility protein (MglA); PFAM: Ras family; TIGRFAM: small GTP-binding protein domain. (201 aa)    
Predicted Functional Partners:
ADW17814.1
KEGG: dps:DP2777 gliding motility regulatory protein (MglB); SPTR: Related to gliding motility regulatory protein (MglB); PFAM: Roadblock/LC7 domain.
 
 
 0.998
ADW17220.1
Signal recognition particle-docking protein FtsY; COGs: COG0552 Signal recognition particle GTPase; InterPro IPR003593: IPR013822: IPR000897: IPR004390; KEGG: dps:DP2936 cell division protein FtsY; PFAM: GTP-binding signal recognition particle SRP54 G- domain; GTP-binding signal recognition particle SRP54 helical bundle; SMART: AAA ATPase; SPTR: Cell division transporter substrate-binding protein FtsY; TIGRFAM: signal recognition particle-docking protein FtsY; PFAM: SRP54-type protein, GTPase domain; SRP54-type protein, helical bundle domain; TIGRFAM: signal recognition particle-dockin [...]
  
 0.919
ffh
Signal recognition particle subunit FFH/SRP54 (srp54); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the i [...]
   
 
 0.790
ADW17816.1
KEGG: dps:DP2775 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.715
ADW19165.1
KEGG: sti:Sthe_2729 hypothetical protein; SPTR: Putative uncharacterized protein.
  
     0.697
ADW19080.1
Hypothetical protein; KEGG: dol:Dole_2199 cyclic nucleotide-binding protein; SPTR: Cyclic nucleotide-binding protein.
  
     0.573
rplN
LSU ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family.
   
   0.572
rplE
LSU ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
    
   0.569
secY
Protein translocase subunit secY/sec61 alpha; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
   
 0.568
ADW19349.1
COGs: COG4972 Tfp pilus assembly protein ATPase PilM; InterPro IPR005883; KEGG: dps:DP0108 fimbrial assembly protein PilM; SPTR: Related to fimbrial assembly protein PilM; TIGRFAM: type IV pilus assembly protein PilM; PFAM: Competence protein A; Cell division protein FtsA; TIGRFAM: type IV pilus assembly protein PilM.
  
   
 0.423
Your Current Organism:
Desulfobulbus propionicus
NCBI taxonomy Id: 577650
Other names: D. propionicus DSM 2032, Desulfobulbus propionicus DSM 2032, Desulfobulbus propionicus str. DSM 2032, Desulfobulbus propionicus strain DSM 2032
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