STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADW18047.1Iron-only hydrogenase maturation protein HydG; COGs: COG1060 Thiamine biosynthesis protein ThiH; InterPro IPR007197: IPR010722; KEGG: cbi:CLJ_B3912 thiamine biosynthesis protein ThiH; PFAM: biotin and thiamin synthesis associated; Radical SAM domain protein; SPTR: Putative thiazole biosynthesis protein; PFAM: Biotin and Thiamin Synthesis associated domain; TIGRFAM: thiazole biosynthesis protein ThiH. (477 aa)    
Predicted Functional Partners:
thiG
Thiazole-phosphate synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
 0.991
ADW18074.1
Tyrosine lyase ThiH; COGs: COG1060 Thiamine biosynthesis protein ThiH; InterPro IPR012726: IPR007197: IPR010722; KEGG: mta:Moth_1664 thiamine biosynthesis protein ThiH; PFAM: biotin and thiamin synthesis associated; Radical SAM domain protein; SPTR: Thiazole biosynthesis ThiH; TIGRFAM: thiazole biosynthesis protein ThiH; PFAM: Radical SAM superfamily; Biotin and Thiamin Synthesis associated domain; TIGRFAM: thiazole biosynthesis protein ThiH.
  
  
 
0.918
ADW17755.1
Iron-only hydrogenase maturation protein HydF; COGs: COG1160 GTPase; InterPro IPR005225: IPR002917; KEGG: sfu:Sfum_1843 small GTP-binding protein; PFAM: GTP-binding protein HSR1-related; SPTR: Small GTP-binding protein; TIGRFAM: small GTP-binding protein; PFAM: GTPase of unknown function; TIGRFAM: small GTP-binding protein domain.
   
 0.900
thiC
Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
 
  
 0.861
ADW18050.1
Hydrogenase, Fe-only; COGs: COG4624 Iron only hydrogenase large subunit C-terminal domain; InterProIPR017900: IPR006311: IPR013352: IPR017909: IPR 017896: IPR004108: IPR003149; KEGG: drm:Dred_0463 hydrogenases, Fe-only; PFAM: hydrogenase large subunit domain protein; iron hydrogenase small subunit; PRIAM: Ferredoxin hydrogenase; SPTR: Hydrogenases, Fe-only; TIGRFAM: hydrogenase, Fe-only; PFAM: Iron only hydrogenase large subunit, C-terminal domain; Iron hydrogenase small subunit; TIGRFAM: hydrogenases, Fe-only.
 
     0.860
ADW17758.1
InterPro IPR001932: IPR010822; KEGG: sfu:Sfum_1847 stage II sporulation E family protein; PFAM: Stage II sporulation protein E; SMART: protein phosphatase 2C domain protein; SPTR: Stage II sporulation E family protein; PFAM: Stage II sporulation protein E (SpoIIE).
  
    0.855
ADW18029.1
Thiamine-phosphate diphosphorylase; COGs: COG0352 Thiamine monophosphate synthase; InterPro IPR003733; KEGG: dba:Dbac_0929 thiamine-phosphate pyrophosphorylase; PFAM: thiamine monophosphate synthase; SPTR: Thiamine-phosphate pyrophosphorylase; TIGRFAM: thiamine-phosphate pyrophosphorylase; PFAM: Thiamine monophosphate synthase/TENI; TIGRFAM: thiamine-phosphate pyrophosphorylase.
  
  
 0.835
ADW18076.1
Thiamine-phosphate diphosphorylase; COGs: COG0352 Thiamine monophosphate synthase; InterPro IPR003733; KEGG: pth:PTH_0643 thiamine monophosphate synthase; PFAM: thiamine monophosphate synthase; SPTR: Thiamine-phosphate pyrophosphorylase; TIGRFAM: thiamine-phosphate pyrophosphorylase; PFAM: Thiamine monophosphate synthase/TENI; TIGRFAM: thiamine-phosphate pyrophosphorylase.
  
  
 0.835
ADW17753.1
NAD(P)-dependent iron-only hydrogenase catalytic subunit; COGs: COG4624 Iron only hydrogenase large subunit C-terminal domain; InterProIPR013352: IPR001041: IPR019574: IPR004108: IPR 003149: IPR017896: IPR017900: IPR000283; KEGG: dma:DMR_07830 putative Fe hydrogenase; PFAM: hydrogenase large subunit domain protein; NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding; ferredoxin; iron hydrogenase small subunit; SPTR: Putative Fe hydrogenase; TIGRFAM: hydrogenase, Fe-only; PFAM: Iron only hydrogenase large subunit, C-terminal domain; NADH-ubiquinone oxidoreductase-G iron-sulf [...]
 
   
 0.832
ADW18072.1
Thiamine biosynthesis protein ThiS; InterPro IPR010035: IPR003749; KEGG: pth:PTH_0639 sulfur transfer protein; PFAM: thiamineS protein; SPTR: Sulfur transfer protein; TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: ThiS family; TIGRFAM: thiamine biosynthesis protein ThiS.
  
    0.817
Your Current Organism:
Desulfobulbus propionicus
NCBI taxonomy Id: 577650
Other names: D. propionicus DSM 2032, Desulfobulbus propionicus DSM 2032, Desulfobulbus propionicus str. DSM 2032, Desulfobulbus propionicus strain DSM 2032
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