STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADW18074.1Tyrosine lyase ThiH; COGs: COG1060 Thiamine biosynthesis protein ThiH; InterPro IPR012726: IPR007197: IPR010722; KEGG: mta:Moth_1664 thiamine biosynthesis protein ThiH; PFAM: biotin and thiamin synthesis associated; Radical SAM domain protein; SPTR: Thiazole biosynthesis ThiH; TIGRFAM: thiazole biosynthesis protein ThiH; PFAM: Radical SAM superfamily; Biotin and Thiamin Synthesis associated domain; TIGRFAM: thiazole biosynthesis protein ThiH. (369 aa)    
Predicted Functional Partners:
thiG
Thiazole-phosphate synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 0.999
thiC
Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
  
 0.984
ADW18076.1
Thiamine-phosphate diphosphorylase; COGs: COG0352 Thiamine monophosphate synthase; InterPro IPR003733; KEGG: pth:PTH_0643 thiamine monophosphate synthase; PFAM: thiamine monophosphate synthase; SPTR: Thiamine-phosphate pyrophosphorylase; TIGRFAM: thiamine-phosphate pyrophosphorylase; PFAM: Thiamine monophosphate synthase/TENI; TIGRFAM: thiamine-phosphate pyrophosphorylase.
 
  
 0.972
ADW18072.1
Thiamine biosynthesis protein ThiS; InterPro IPR010035: IPR003749; KEGG: pth:PTH_0639 sulfur transfer protein; PFAM: thiamineS protein; SPTR: Sulfur transfer protein; TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: ThiS family; TIGRFAM: thiamine biosynthesis protein ThiS.
 
    0.959
ADW18075.1
UBA/THIF-type NAD/FAD binding protein; COGs: COG0476 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 2; InterPro IPR000594; KEGG: cth:Cthe_0600 thiamine biosynthesis protein ThiF; PFAM: UBA/THIF-type NAD/FAD binding protein; SPTR: Thiamine biosynthesis protein ThiF; PFAM: ThiF family; TIGRFAM: thiamine biosynthesis protein ThiF, family 2.
 
  
 0.950
ADW18047.1
Iron-only hydrogenase maturation protein HydG; COGs: COG1060 Thiamine biosynthesis protein ThiH; InterPro IPR007197: IPR010722; KEGG: cbi:CLJ_B3912 thiamine biosynthesis protein ThiH; PFAM: biotin and thiamin synthesis associated; Radical SAM domain protein; SPTR: Putative thiazole biosynthesis protein; PFAM: Biotin and Thiamin Synthesis associated domain; TIGRFAM: thiazole biosynthesis protein ThiH.
  
  
 
0.918
ADW18029.1
Thiamine-phosphate diphosphorylase; COGs: COG0352 Thiamine monophosphate synthase; InterPro IPR003733; KEGG: dba:Dbac_0929 thiamine-phosphate pyrophosphorylase; PFAM: thiamine monophosphate synthase; SPTR: Thiamine-phosphate pyrophosphorylase; TIGRFAM: thiamine-phosphate pyrophosphorylase; PFAM: Thiamine monophosphate synthase/TENI; TIGRFAM: thiamine-phosphate pyrophosphorylase.
  
  
 0.835
ADW18362.1
Flagellar basal-body rod protein FlgB; COGs: COG1815 Flagellar basal body protein; InterPro IPR001444: IPR006300; KEGG: dps:DP2653 flagellar basal-body rod protein (FlgB); PFAM: flagellar basal body rod protein; SPTR: Flagellar basal-body rod protein FlgB; TIGRFAM: flagellar basal-body rod protein FlgB; PFAM: Flagella basal body rod protein; TIGRFAM: flagellar basal-body rod protein FlgB.
   
    0.808
ADW17758.1
InterPro IPR001932: IPR010822; KEGG: sfu:Sfum_1847 stage II sporulation E family protein; PFAM: Stage II sporulation protein E; SMART: protein phosphatase 2C domain protein; SPTR: Stage II sporulation E family protein; PFAM: Stage II sporulation protein E (SpoIIE).
   
    0.777
ADW19304.1
COGs: COG2208 Serine phosphatase RsbU regulator of sigma subunit; InterPro IPR004010: IPR003660: IPR010822: IPR001932; KEGG: ppd:Ppro_1527 serine phosphatase; PFAM: Stage II sporulation protein E; Cache domain protein; histidine kinase HAMP region domain protein; SMART: protein phosphatase 2C domain protein; histidine kinase HAMP region domain protein; SPTR: Serine phosphatase; PFAM: HAMP domain; Cache domain; Stage II sporulation protein E (SpoIIE).
   
    0.777
Your Current Organism:
Desulfobulbus propionicus
NCBI taxonomy Id: 577650
Other names: D. propionicus DSM 2032, Desulfobulbus propionicus DSM 2032, Desulfobulbus propionicus str. DSM 2032, Desulfobulbus propionicus strain DSM 2032
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