Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADW18084.1Adenylate cyclase; COGs: COG2954 conserved hypothetical protein; InterPro IPR008172: IPR012042; KEGG: dds:Ddes_1849 adenylate cyclase; PFAM: adenylate cyclase; SPTR: Adenylate cyclase; PFAM: CYTH domain. (156 aa)    
Predicted Functional Partners:
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
    
 0.902
ADW16898.1
Adenylate/guanylate cyclase; COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR001789: IPR001054: IPR018297; KEGG: bja:blr2288 two-component hybrid sensor and regulator; PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; response regulator receiver; SMART: adenylyl cyclase class-3/4/guanylyl cyclase; response regulator receiver; SPTR: Adenylate/guanylate cyclase; PFAM: Adenylate and Guanylate cyclase catalytic domain; Response regulator receiver domain.
     
  0.900
ADW17001.1
(p)ppGpp synthetase I, SpoT/RelA; COGs: COG0317 Guanosine polyphosphate pyrophosphohydrolase/synthetase; InterProIPR006674: IPR007685: IPR004095: IPR004811: IPR 000408; KEGG: dps:DP1165 GTP pyrophosphokinase; PFAM: RelA/SpoT domain protein; metal-dependent phosphohydrolase HD sub domain; TGS domain-containing protein; PRIAM: GTP diphosphokinase; SPTR: Probable GTP pyrophosphokinase; TIGRFAM: RelA/SpoT family protein; PFAM: TGS domain; Region found in RelA / SpoT proteins; TIGRFAM: (p)ppGpp synthetase, RelA/SpoT family.
     
  0.900
ADW18725.1
(p)ppGpp synthetase I, SpoT/RelA; COGs: COG0317 Guanosine polyphosphate pyrophosphohydrolase/synthetase; InterPro IPR003607: IPR006674: IPR007685: IPR004095; KEGG: dps:DP1905 GTP pyrophosphokinase; PFAM: TGS domain-containing protein; metal-dependent phosphohydrolase HD sub domain; RelA/SpoT domain protein; PRIAM: GTP diphosphokinase; SMART: metal-dependent phosphohydrolase HD region; SPTR: Probable GTP pyrophosphokinase; PFAM: HD domain; Region found in RelA / SpoT proteins; TGS domain; TIGRFAM: (p)ppGpp synthetase, RelA/SpoT family.
     
  0.900
ADW18966.1
Adenylate/guanylate cyclase with GAF sensor(s); COGs: COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain); InterPro IPR001054: IPR003018; KEGG: dal:Dalk_4220 adenylate/guanylate cyclase with GAF sensor(s); PFAM: GAF domain protein; adenylyl cyclase class-3/4/guanylyl cyclase; SMART: GAF domain protein; adenylyl cyclase class-3/4/guanylyl cyclase; SPTR: Adenylate/guanylate cyclase with GAF sensor(S); manually curated; PFAM: Adenylate and Guanylate cyclase catalytic domain; GAF domain.
     
  0.900
ribBA
GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
    
  0.801
ADW17156.1
COGs: COG2896 Molybdenum cofactor biosynthesis protein; InterProIPR006638: IPR007197: IPR010505: IPR000385: IPR 013483; KEGG: dps:DP2172 molybdenum cofactor biosynthesis protein A (MoaA); PFAM: molybdenum cofactor synthesis domain protein; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: Probable molybdenum cofactor biosynthesis protein A (MoaA); TIGRFAM: molybdenum cofactor biosynthesis protein A; PFAM: Molybdenum Cofactor Synthesis C; Radical SAM superfamily; TIGRFAM: molybdenum cofactor biosynthesis protein A, bacterial.
     
  0.800
ADW18117.1
GTP cyclohydrolase I; COGs: COG1469 conserved hypothetical protein; InterPro IPR003801; KEGG: dak:DaAHT2_1707 protein of unknown function DUF198; PFAM: protein of unknown function DUF198; PRIAM: GTP cyclohydrolase I; SPTR: Putative uncharacterized protein; PFAM: Uncharacterized ACR, COG1469.
     
  0.800
ADW18963.1
GTP cyclohydrolase I; COGs: COG1469 conserved hypothetical protein; InterPro IPR003801; KEGG: dak:DaAHT2_0489 protein of unknown function DUF198; PFAM: protein of unknown function DUF198; PRIAM: GTP cyclohydrolase I; SPTR: Putative uncharacterized protein; PFAM: Uncharacterized ACR, COG1469.
     
  0.800
ADW18085.1
Catalase; COGs: COG0753 Catalase; InterPro IPR018028: IPR002226: IPR011614: IPR010582; KEGG: dvl:Dvul_3018 catalase; PFAM: Catalase related subgroup; Catalase domain protein; PRIAM: Catalase; SPTR: Catalase; PFAM: Catalase; Catalase-related immune-responsive.
       0.441
Your Current Organism:
Desulfobulbus propionicus
NCBI taxonomy Id: 577650
Other names: D. propionicus DSM 2032, Desulfobulbus propionicus DSM 2032, Desulfobulbus propionicus str. DSM 2032, Desulfobulbus propionicus strain DSM 2032
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