STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Experiments
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[Homology]
Score
ADW18154.1COGs: COG0117 Pyrimidine deaminase; InterProIPR016192: IPR004794: IPR011549: IPR002125: IPR 002734; KEGG: dak:DaAHT2_1279 riboflavin biosynthesis protein RibD; PFAM: bifunctional deaminase-reductase domain protein; CMP/dCMP deaminase zinc-binding; SPTR: Riboflavin biosynthesis protein RibD; TIGRFAM: riboflavin biosynthesis protein RibD; PFAM: RibD C-terminal domain; Cytidine and deoxycytidylate deaminase zinc-binding region; TIGRFAM: riboflavin-specific deaminase C-terminal domain; riboflavin biosynthesis protein RibD. (368 aa)    
Predicted Functional Partners:
ADW16940.1
COGs: COG0307 Riboflavin synthase alpha chain; InterPro IPR001783; KEGG: dak:DaAHT2_1278 riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; PRIAM: Riboflavin synthase; SPTR: Lumazine-binding protein; TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine binding domain; TIGRFAM: riboflavin synthase, alpha subunit.
  
 0.999
ribBA
GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
 0.999
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
 
 0.995
ADW18080.1
COGs: COG0108 3 4-dihydroxy-2-butanone 4-phosphate synthase; InterPro IPR000422; KEGG: hch:HCH_01388 3,4-dihydroxy-2-butanone 4-phosphate synthase; PFAM: 34-dihydroxy-2-butanone 4-phosphate synthase; SPTR: 3,4-dihydroxy-2-butanone 4-phosphate synthase; TIGRFAM: 3,4-dihydroxy-2-butanone 4-phosphate synthase; PFAM: 3,4-dihydroxy-2-butanone 4-phosphate synthase; TIGRFAM: 3,4-dihydroxy-2-butanone 4-phosphate synthase.
 
 0.992
nrdR
ATP-cone domain protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family.
 
  
 0.943
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
   
   0.893
ADW18310.1
Flagellar protein FlaG protein; InterPro IPR005186; KEGG: pca:Pcar_1113 uncharacterized flagellar protein FlaG; PFAM: flagellar protein FlaG protein; SPTR: Flagellar protein FlaG protein; PFAM: FlaG protein.
   
   0.866
ADW18191.1
COGs: COG0611 Thiamine monophosphate kinase; InterPro IPR006283: IPR000728: IPR010918; KEGG: dak:DaAHT2_1499 thiamine-monophosphate kinase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; PRIAM: Thiamine-phosphate kinase; SPTR: Thiamine-monophosphate kinase; TIGRFAM: thiamine-monophosphate kinase; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: thiamine-monophosphate kinase.
   
 0.825
ADW18501.1
COGs: COG5016 Pyruvate/oxaloacetate carboxyltransferase; InterPro IPR000089: IPR000891: IPR003379: IPR001882; KEGG: dal:Dalk_3782 conserved carboxylase region; PFAM: Conserved carboxylase region; pyruvate carboxyltransferase; biotin/lipoyl attachment domain-containing protein; SPTR: Conserved carboxylase region; PFAM: HMGL-like; Conserved carboxylase domain; Biotin-requiring enzyme.
   
   0.721
hisG
ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
  
  
 0.706
Your Current Organism:
Desulfobulbus propionicus
NCBI taxonomy Id: 577650
Other names: D. propionicus DSM 2032, Desulfobulbus propionicus DSM 2032, Desulfobulbus propionicus str. DSM 2032, Desulfobulbus propionicus strain DSM 2032
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