Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADW18242.1UBA/THIF-type NAD/FAD binding protein; COGs: COG0476 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 2; InterPro IPR006140: IPR000594; KEGG: gur:Gura_1193 UBA/ThiF-type NAD/FAD binding protein; PFAM: UBA/THIF-type NAD/FAD binding protein; SPTR: UBA/THIF-type NAD/FAD binding protein; PFAM: MoeZ/MoeB domain; ThiF family. (227 aa)    
Predicted Functional Partners:
ADW18239.1
thiamineS protein; InterPro IPR003749; KEGG: dps:DP2477 molybdopterin converting factor, subunit 1; PFAM: thiamineS protein; SPTR: Similar to molybdopterin converting factor, subunit 1; PFAM: ThiS family.
 
 0.987
nifS
Cysteine desulfurase NifS; Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.
   
 0.967
ADW17210.1
Rhodanese domain protein; COGs: COG0607 Rhodanese-related sulfurtransferase; InterPro IPR001763; KEGG: dba:Dbac_1785 rhodanese domain protein; PFAM: Rhodanese domain protein; SMART: Rhodanese domain protein; SPTR: Rhodanese domain protein; PFAM: Rubrerythrin; Rhodanese-like domain.
 
  
 0.936
ADW18072.1
Thiamine biosynthesis protein ThiS; InterPro IPR010035: IPR003749; KEGG: pth:PTH_0639 sulfur transfer protein; PFAM: thiamineS protein; SPTR: Sulfur transfer protein; TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: ThiS family; TIGRFAM: thiamine biosynthesis protein ThiS.
  
 
 0.923
thiG
Thiazole-phosphate synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
  
 0.894
ADW18940.1
Molybdopterin biosynthesis MoaE protein; COGs: COG0314 Molybdopterin converting factor large subunit; InterPro IPR003448; KEGG: dps:DP2875 molybdenum cofactor biosynthesis protein; PFAM: molybdopterin biosynthesis MoaE protein; SPTR: Similar to molybdenum cofactor biosynthesis protein; PFAM: MoaE protein.
  
 0.886
ADW19079.1
Hypothetical protein; InterPro IPR000608: IPR019734; KEGG: dps:DP0803 hypothetical protein; SPTR: Putative uncharacterized protein.
   
 0.881
thiC
Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
  
  
 0.798
ADW18030.1
COGs: COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; InterPro IPR004399: IPR013749; KEGG: dba:Dbac_0928 phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1; PRIAM: Phosphomethylpyrimidine kinase; SPTR: Phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase.
  
  
 0.775
ADW18240.1
Molybdenum cofactor synthesis domain protein; COGs: COG0303 Molybdopterin biosynthesis enzyme; InterPro IPR020817: IPR005110: IPR001453: IPR005111; KEGG: sfu:Sfum_1700 molybdenum cofactor synthesis domain-containing protein; PFAM: MoeA domain protein domain I and II; molybdopterin binding domain; MoeA domain protein domain IV; SPTR: Molybdopterin molybdochelatase; TIGRFAM: molybdenum cofactor synthesis domain protein; PFAM: Probable molybdopterin binding domain; MoeA N-terminal region (domain I and II); MoeA C-terminal region (domain IV); TIGRFAM: molybdenum cofactor synthesis domain.
 
  
 0.733
Your Current Organism:
Desulfobulbus propionicus
NCBI taxonomy Id: 577650
Other names: D. propionicus DSM 2032, Desulfobulbus propionicus DSM 2032, Desulfobulbus propionicus str. DSM 2032, Desulfobulbus propionicus strain DSM 2032
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