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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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ADW18489.1Putative transcriptional regulator, Crp/Fnr family; COGs: COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase; InterPro IPR000595; KEGG: dol:Dole_2199 cyclic nucleotide-binding protein; PFAM: cyclic nucleotide-binding; SMART: cyclic nucleotide-binding; SPTR: Cyclic nucleotide-binding protein; PFAM: Cyclic nucleotide-binding domain. (364 aa)    
Predicted Functional Partners:
ADW18355.1
Putative transcriptional regulator, Crp/Fnr family; COGs: COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase; InterPro IPR000595: IPR002373: IPR018488; KEGG: dal:Dalk_3876 cyclic nucleotide-binding protein; PFAM: cyclic nucleotide-binding; SMART: cyclic nucleotide-binding; SPTR: Cyclic nucleotide-binding protein; PFAM: Cyclic nucleotide-binding domain.
  
  
  0.975
ADW18966.1
Adenylate/guanylate cyclase with GAF sensor(s); COGs: COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain); InterPro IPR001054: IPR003018; KEGG: dal:Dalk_4220 adenylate/guanylate cyclase with GAF sensor(s); PFAM: GAF domain protein; adenylyl cyclase class-3/4/guanylyl cyclase; SMART: GAF domain protein; adenylyl cyclase class-3/4/guanylyl cyclase; SPTR: Adenylate/guanylate cyclase with GAF sensor(S); manually curated; PFAM: Adenylate and Guanylate cyclase catalytic domain; GAF domain.
 
 
 0.939
rpoA
DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
   0.773
ADW16898.1
Adenylate/guanylate cyclase; COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR001789: IPR001054: IPR018297; KEGG: bja:blr2288 two-component hybrid sensor and regulator; PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; response regulator receiver; SMART: adenylyl cyclase class-3/4/guanylyl cyclase; response regulator receiver; SPTR: Adenylate/guanylate cyclase; PFAM: Adenylate and Guanylate cyclase catalytic domain; Response regulator receiver domain.
 
 
 0.767
rpoB
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 
 0.758
rpoC
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.758
ADW17951.1
RNA polymerase, sigma 70 subunit, RpoD subfamily; COGs: COG0568 DNA-directed RNA polymerase sigma subunit (sigma70/sigma32); InterProIPR014284: IPR007127: IPR009042: IPR007627: IPR 007624: IPR007630: IPR000943; KEGG: dps:DP2503 RNA polymerase sigma factor (RpoD); PFAM: sigma-70 region 2 domain protein; sigma-70 region 1.2; sigma-70 1.1 domain protein; sigma-70 region 3 domain protein; sigma-70 region 4 domain protein; SPTR: RNA polymerase sigma factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70, region 4; Sigma-70 factor, region 1.1; Sigma-70 region 3; Sigma- [...]
    
 
 0.736
ADW19069.1
RNA polymerase, sigma 70 subunit, RpoD subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
    
 
 0.736
rpoZ
DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
    
   0.729
ADW16488.1
Hypothetical protein; COGs: COG1235 Metal-dependent hydrolase of the beta-lactamase superfamily I; KEGG: dak:DaAHT2_2295 hypothetical protein; SPTR: Putative uncharacterized protein.
 
     0.711
Your Current Organism:
Desulfobulbus propionicus
NCBI taxonomy Id: 577650
Other names: D. propionicus DSM 2032, Desulfobulbus propionicus DSM 2032, Desulfobulbus propionicus str. DSM 2032, Desulfobulbus propionicus strain DSM 2032
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