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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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ADW18509.1COGs: COG0066 3-isopropylmalate dehydratase small subunit; InterPro IPR000573; KEGG: dps:DP1958 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase domain-containing protein; SPTR: Related to 3-isopropylmalate dehydratase, small subunit; PFAM: Aconitase C-terminal domain; TIGRFAM: 3-isopropylmalate dehydratase, small subunit. (175 aa)    
Predicted Functional Partners:
ADW18508.1
COGs: COG0065 3-isopropylmalate dehydratase large subunit; InterPro IPR001030: IPR018136: IPR011826: IPR006251; KEGG: dak:DaAHT2_0530 homoaconitate hydratase family protein; PFAM: aconitate hydratase domain-containing protein; SPTR: Homoaconitate hydratase family protein; TIGRFAM: homoaconitate hydratase family protein; 3-isopropylmalate dehydratase; PFAM: Aconitase family (aconitate hydratase); TIGRFAM: 3-isopropylmalate dehydratase, large subunit; homoaconitate hydratase family protein; Belongs to the aconitase/IPM isomerase family.
 0.999
ADW17083.1
COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR001804: IPR004429: IPR019818; KEGG: dps:DP1284 3-isopropylmalate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; PRIAM: 3-isopropylmalate dehydrogenase; SPTR: 3-isopropylmalate dehydrogenase; TIGRFAM: 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: 3-isopropylmalate dehydrogenase.
 
 
 0.998
ADW17926.1
(R)-citramalate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterProIPR005675: IPR000891: IPR013709: IPR001917: IPR 002034; KEGG: dps:DP0660 putative alpha-isopropylmalate/homocitrate synthase family transferase; PFAM: LeuA allosteric (dimerisation) domain-containing protein; pyruvate carboxyltransferase; SPTR: Probable 2-isopropylmalate synthase; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: HMGL-like; LeuA allosteric (dimerisation) domain; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to [...]
 
 
 0.988
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
  
 
 0.983
ADW19406.1
COGs: COG0059 Ketol-acid reductoisomerase; InterPro IPR013116: IPR000506: IPR014359: IPR013023; KEGG: dat:HRM2_21070 ketol-acid reductoisomerase; PFAM: acetohydroxy acid isomeroreductase; Acetohydroxy acid isomeroreductase catalytic domain-containing protein; PRIAM: Ketol-acid reductoisomerase; SPTR: IlvC; TIGRFAM: ketol-acid reductoisomerase; PFAM: Acetohydroxy acid isomeroreductase, catalytic domain; TIGRFAM: ketol-acid reductoisomerase.
 
  
 0.942
ADW18672.1
COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR004789: IPR002912: IPR019455; KEGG: dps:DP2770 acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein; SPTR: Probable acetolactate synthase, small subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit.
 
  
 0.922
ADW18501.1
COGs: COG5016 Pyruvate/oxaloacetate carboxyltransferase; InterPro IPR000089: IPR000891: IPR003379: IPR001882; KEGG: dal:Dalk_3782 conserved carboxylase region; PFAM: Conserved carboxylase region; pyruvate carboxyltransferase; biotin/lipoyl attachment domain-containing protein; SPTR: Conserved carboxylase region; PFAM: HMGL-like; Conserved carboxylase domain; Biotin-requiring enzyme.
  
 
 0.881
ADW17064.1
COGs: COG0498 Threonine synthase; InterPro IPR001926: IPR004450: IPR000634; KEGG: gme:Gmet_1631 threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; PRIAM: Threonine synthase; SPTR: L-threonine synthase; TIGRFAM: threonine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase.
  
  
 0.863
ADW18671.1
Acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterProIPR012846: IPR000399: IPR012001: IPR012000: IPR 011766; KEGG: dak:DaAHT2_0725 acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein; SPTR: Acetolactate synthase, large subunit, biosynthetic type; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP b [...]
 
  
 0.861
ADW17557.1
Acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012001: IPR012000: IPR011766: IPR000399; KEGG: ppd:Ppro_2814 thiamine pyrophosphate binding domain-containing protein; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein; SPTR: Thiamine pyrophosphate enzyme domain protein TPP-binding; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain.
 
  
 0.858
Your Current Organism:
Desulfobulbus propionicus
NCBI taxonomy Id: 577650
Other names: D. propionicus DSM 2032, Desulfobulbus propionicus DSM 2032, Desulfobulbus propionicus str. DSM 2032, Desulfobulbus propionicus strain DSM 2032
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