STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hslVATP dependent peptidase CodWX, CodW component; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. (179 aa)    
Predicted Functional Partners:
hslU
Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
 0.999
ADW17097.1
GrpE protein; COGs: COG0576 Molecular chaperone GrpE (heat shock protein); InterPro IPR000740; KEGG: dak:DaAHT2_0057 GrpE protein; PFAM: GrpE protein; SPTR: Protein grpE; PFAM: GrpE.
  
  
 0.905
htpG
Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity.
   
  
 0.892
ADW18122.1
COGs: COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain; InterProIPR003095: IPR012724: IPR018253: IPR001623: IPR 001305: IPR002939; KEGG: dps:DP1482 chaperone protein DnaJ; PFAM: chaperone DnaJ domain protein; heat shock protein DnaJ domain protein; DnaJ central domain protein; SMART: heat shock protein DnaJ domain protein; SPTR: Chaperone protein dnaJ; TIGRFAM: chaperone protein DnaJ; PFAM: DnaJ domain; DnaJ central domain (4 repeats); DnaJ C terminal region; TIGRFAM: chaperone protein DnaJ.
   
  
 0.884
groL
Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
   
 
 0.880
groS
Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
   
  
 0.874
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
  
 0.867
ADW17196.1
KEGG: tau:Tola_0702 hypothetical protein; SPTR: Putative uncharacterized protein.
   
  
 0.851
ADW18962.1
COGs: COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog); InterPro IPR002942; KEGG: tkm:TK90_2048 RNA-binding S4 domain protein; PFAM: RNA-binding S4 domain protein; SMART: RNA-binding S4 domain protein; SPTR: RNA-binding S4 domain protein; PFAM: S4 domain.
  
    0.831
ADW17632.1
Response regulator receiver protein; COGs: COG0466 ATP-dependent Lon protease; InterProIPR001789: IPR003959: IPR003593: IPR001984: IPR 008268; KEGG: dma:DMR_10810 ATP-dependent protease Lon; PFAM: AAA ATPase central domain protein; response regulator receiver; SMART: response regulator receiver; AAA ATPase; SPTR: ATP-dependent protease Lon; PFAM: Response regulator receiver domain; ATPase family associated with various cellular activities (AAA); Lon protease (S16) C-terminal proteolytic domain; TIGRFAM: ATP-dependent protease La.
  
  
 0.822
Your Current Organism:
Desulfobulbus propionicus
NCBI taxonomy Id: 577650
Other names: D. propionicus DSM 2032, Desulfobulbus propionicus DSM 2032, Desulfobulbus propionicus str. DSM 2032, Desulfobulbus propionicus strain DSM 2032
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.