STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADW18725.1(p)ppGpp synthetase I, SpoT/RelA; COGs: COG0317 Guanosine polyphosphate pyrophosphohydrolase/synthetase; InterPro IPR003607: IPR006674: IPR007685: IPR004095; KEGG: dps:DP1905 GTP pyrophosphokinase; PFAM: TGS domain-containing protein; metal-dependent phosphohydrolase HD sub domain; RelA/SpoT domain protein; PRIAM: GTP diphosphokinase; SMART: metal-dependent phosphohydrolase HD region; SPTR: Probable GTP pyrophosphokinase; PFAM: HD domain; Region found in RelA / SpoT proteins; TGS domain; TIGRFAM: (p)ppGpp synthetase, RelA/SpoT family. (701 aa)    
Predicted Functional Partners:
ADW17976.1
COGs: COG0360 Ribosomal protein S6; InterPro IPR000529: IPR020814: IPR020815; KEGG: dal:Dalk_0919 30S ribosomal protein S6; PFAM: Ribosomal protein S6, bacterial-like; SPTR: 30S ribosomal protein S6; TIGRFAM: ribosomal protein S6; PFAM: Ribosomal protein S6; TIGRFAM: ribosomal protein S6.
  
 
 0.950
ADW17001.1
(p)ppGpp synthetase I, SpoT/RelA; COGs: COG0317 Guanosine polyphosphate pyrophosphohydrolase/synthetase; InterProIPR006674: IPR007685: IPR004095: IPR004811: IPR 000408; KEGG: dps:DP1165 GTP pyrophosphokinase; PFAM: RelA/SpoT domain protein; metal-dependent phosphohydrolase HD sub domain; TGS domain-containing protein; PRIAM: GTP diphosphokinase; SPTR: Probable GTP pyrophosphokinase; TIGRFAM: RelA/SpoT family protein; PFAM: TGS domain; Region found in RelA / SpoT proteins; TIGRFAM: (p)ppGpp synthetase, RelA/SpoT family.
  
  
 
0.925
ADW18923.1
COGs: COG0194 Guanylate kinase; InterPro IPR008144: IPR017665: IPR020590: IPR008145; KEGG: dak:DaAHT2_0280 guanylate kinase; PFAM: guanylate kinase; PRIAM: Guanylate kinase; SMART: guanylate kinase/L-type calcium channel region; SPTR: Guanylate kinase; TIGRFAM: guanylate kinase; PFAM: Guanylate kinase; TIGRFAM: guanylate kinase.
  
 
 0.924
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
    
 0.920
ADW18966.1
Adenylate/guanylate cyclase with GAF sensor(s); COGs: COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain); InterPro IPR001054: IPR003018; KEGG: dal:Dalk_4220 adenylate/guanylate cyclase with GAF sensor(s); PFAM: GAF domain protein; adenylyl cyclase class-3/4/guanylyl cyclase; SMART: GAF domain protein; adenylyl cyclase class-3/4/guanylyl cyclase; SPTR: Adenylate/guanylate cyclase with GAF sensor(S); manually curated; PFAM: Adenylate and Guanylate cyclase catalytic domain; GAF domain.
    
 0.914
ADW19113.1
Response regulator receiver protein; COGs: COG0469 Pyruvate kinase; InterPro IPR001789: IPR015793: IPR018209: IPR001697; KEGG: bbe:BBR47_13840 pyruvate kinase; PFAM: Pyruvate kinase barrel; response regulator receiver; SMART: response regulator receiver; SPTR: Pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase, barrel domain; Response regulator receiver domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase.
   
 
 0.914
ADW16898.1
Adenylate/guanylate cyclase; COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR001789: IPR001054: IPR018297; KEGG: bja:blr2288 two-component hybrid sensor and regulator; PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; response regulator receiver; SMART: adenylyl cyclase class-3/4/guanylyl cyclase; response regulator receiver; SPTR: Adenylate/guanylate cyclase; PFAM: Adenylate and Guanylate cyclase catalytic domain; Response regulator receiver domain.
   
 
 0.913
rplK
LSU ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
  
 
 0.910
ADW19383.1
COGs: COG0469 Pyruvate kinase; InterPro IPR015793: IPR015794: IPR001697; KEGG: sfu:Sfum_2959 pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; PRIAM: Pyruvate kinase; SPTR: Pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase, barrel domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase.
   
 
 0.905
ADW17459.1
Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; InterPro IPR013344: IPR013509: IPR000788; KEGG: dps:DP2827 ribonucleoside-diphosphate reductase; PFAM: ribonucleotide reductase large subunit; Ribonucleotide reductase large subunit domain protein; PRIAM: Ribonucleoside-diphosphate reductase; SPTR: Ribonucleoside-diphosphate reductase; TIGRFAM: ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; PFAM: Ribonucleotide reductase, all-alpha domain; Ribonucleotide reductase, barrel domain; TIGRFAM: ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent.
     
 0.901
Your Current Organism:
Desulfobulbus propionicus
NCBI taxonomy Id: 577650
Other names: D. propionicus DSM 2032, Desulfobulbus propionicus DSM 2032, Desulfobulbus propionicus str. DSM 2032, Desulfobulbus propionicus strain DSM 2032
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