| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADW18711.1 | ADW18745.1 | Despr_2575 | Despr_2609 | Hydroxymethylbilane synthase; COGs: COG0181 Porphobilinogen deaminase; InterPro IPR000860; KEGG: dak:DaAHT2_0535 porphobilinogen deaminase; PFAM: Porphobilinogen deaminase; SPTR: Porphobilinogen deaminase; TIGRFAM: porphobilinogen deaminase; PFAM: Porphobilinogen deaminase, C-terminal domain; Porphobilinogen deaminase, dipyromethane cofactor binding domain; TIGRFAM: porphobilinogen deaminase. | COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR006367; KEGG: dak:DaAHT2_2550 siroheme synthase; SPTR: Siroheme synthase; TIGRFAM: siroheme synthase; TIGRFAM: siroheme synthase, N-terminal domain. | 0.938 |
| ADW18711.1 | ADW19153.1 | Despr_2575 | Despr_3020 | Hydroxymethylbilane synthase; COGs: COG0181 Porphobilinogen deaminase; InterPro IPR000860; KEGG: dak:DaAHT2_0535 porphobilinogen deaminase; PFAM: Porphobilinogen deaminase; SPTR: Porphobilinogen deaminase; TIGRFAM: porphobilinogen deaminase; PFAM: Porphobilinogen deaminase, C-terminal domain; Porphobilinogen deaminase, dipyromethane cofactor binding domain; TIGRFAM: porphobilinogen deaminase. | COGs: COG2875 Precorrin-4 methylase; InterPro IPR000878: IPR003043: IPR006362; KEGG: dps:DP0222 precorrin-4 C11-methyltransferase (CobM); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-4 C(11)-methyltransferase; SPTR: Probable precorrin-4 C11-methyltransferase (CobM); TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-4 C11-methyltransferase. | 0.941 |
| ADW18711.1 | cobA | Despr_2575 | Despr_2576 | Hydroxymethylbilane synthase; COGs: COG0181 Porphobilinogen deaminase; InterPro IPR000860; KEGG: dak:DaAHT2_0535 porphobilinogen deaminase; PFAM: Porphobilinogen deaminase; SPTR: Porphobilinogen deaminase; TIGRFAM: porphobilinogen deaminase; PFAM: Porphobilinogen deaminase, C-terminal domain; Porphobilinogen deaminase, dipyromethane cofactor binding domain; TIGRFAM: porphobilinogen deaminase. | COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR006366: IPR003043: IPR000878: IPR003754; KEGG: dps:DP1734 uroporphyrinogen III synthase/methyltransferase (HemD+CobA); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; SPTR: Probable uroporphyrinogen III synthase/methyltransferase (HemD+CobA); TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; Uroporphyrinogen-III synthase HemD; TIGRFAM: uroporphyrin-III C-methyltransferase. | 0.999 |
| ADW18711.1 | hemL | Despr_2575 | Despr_2958 | Hydroxymethylbilane synthase; COGs: COG0181 Porphobilinogen deaminase; InterPro IPR000860; KEGG: dak:DaAHT2_0535 porphobilinogen deaminase; PFAM: Porphobilinogen deaminase; SPTR: Porphobilinogen deaminase; TIGRFAM: porphobilinogen deaminase; PFAM: Porphobilinogen deaminase, C-terminal domain; Porphobilinogen deaminase, dipyromethane cofactor binding domain; TIGRFAM: porphobilinogen deaminase. | COGs: COG0001 Glutamate-1-semialdehyde aminotransferase; InterPro IPR005814: IPR004639; KEGG: dps:DP0812 glutamate-1-semialdehyde 2,1-aminomutase; PFAM: aminotransferase class-III; SPTR: Glutamate-1-semialdehyde 2,1-aminomutase; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: Aminotransferase class-III; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase. | 0.974 |
| ADW18745.1 | ADW18711.1 | Despr_2609 | Despr_2575 | COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR006367; KEGG: dak:DaAHT2_2550 siroheme synthase; SPTR: Siroheme synthase; TIGRFAM: siroheme synthase; TIGRFAM: siroheme synthase, N-terminal domain. | Hydroxymethylbilane synthase; COGs: COG0181 Porphobilinogen deaminase; InterPro IPR000860; KEGG: dak:DaAHT2_0535 porphobilinogen deaminase; PFAM: Porphobilinogen deaminase; SPTR: Porphobilinogen deaminase; TIGRFAM: porphobilinogen deaminase; PFAM: Porphobilinogen deaminase, C-terminal domain; Porphobilinogen deaminase, dipyromethane cofactor binding domain; TIGRFAM: porphobilinogen deaminase. | 0.938 |
| ADW18745.1 | ADW19151.1 | Despr_2609 | Despr_3018 | COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR006367; KEGG: dak:DaAHT2_2550 siroheme synthase; SPTR: Siroheme synthase; TIGRFAM: siroheme synthase; TIGRFAM: siroheme synthase, N-terminal domain. | COGs: COG1010 Precorrin-3B methylase; InterPro IPR000878: IPR006363; KEGG: dps:DP0224 precorrin-3B C17-methyltransferase (CobJ); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Probable precorrin-3B C17-methyltransferase (CobJ); TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-3B C17-methyltransferase. | 0.940 |
| ADW18745.1 | ADW19152.1 | Despr_2609 | Despr_3019 | COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR006367; KEGG: dak:DaAHT2_2550 siroheme synthase; SPTR: Siroheme synthase; TIGRFAM: siroheme synthase; TIGRFAM: siroheme synthase, N-terminal domain. | COGs: COG2073 Cobalamin biosynthesis protein CbiG; InterPro IPR002750; KEGG: dak:DaAHT2_1587 cobalamin (vitamin B12) biosynthesis CbiG protein; PFAM: cobalamin (vitamin B12) biosynthesis CbiG protein; SPTR: Cobalamin (Vitamin B12) biosynthesis CbiG protein; PFAM: Cobalamin synthesis G C-terminus; Cobalamin synthesis G N-terminal. | 0.936 |
| ADW18745.1 | ADW19153.1 | Despr_2609 | Despr_3020 | COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR006367; KEGG: dak:DaAHT2_2550 siroheme synthase; SPTR: Siroheme synthase; TIGRFAM: siroheme synthase; TIGRFAM: siroheme synthase, N-terminal domain. | COGs: COG2875 Precorrin-4 methylase; InterPro IPR000878: IPR003043: IPR006362; KEGG: dps:DP0222 precorrin-4 C11-methyltransferase (CobM); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-4 C(11)-methyltransferase; SPTR: Probable precorrin-4 C11-methyltransferase (CobM); TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-4 C11-methyltransferase. | 0.977 |
| ADW18745.1 | ADW19154.1 | Despr_2609 | Despr_3021 | COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR006367; KEGG: dak:DaAHT2_2550 siroheme synthase; SPTR: Siroheme synthase; TIGRFAM: siroheme synthase; TIGRFAM: siroheme synthase, N-terminal domain. | COGs: COG2243 Precorrin-2 methylase; InterPro IPR000878: IPR012382: IPR006364; KEGG: dak:DaAHT2_1585 precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Precorrin-2 C20-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-2 C20-methyltransferase. | 0.934 |
| ADW18745.1 | ADW19162.1 | Despr_2609 | Despr_3029 | COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR006367; KEGG: dak:DaAHT2_2550 siroheme synthase; SPTR: Siroheme synthase; TIGRFAM: siroheme synthase; TIGRFAM: siroheme synthase, N-terminal domain. | Anaerobic cobalt chelatase; COGs: COG4822 Cobalamin biosynthesis protein CbiK Co2+ chelatase; InterPro IPR010388; KEGG: dap:Dacet_0164 sirohydrochlorin cobaltochelatase; PFAM: anaerobic cobalt chelatase; SPTR: Sirohydrochlorin cobaltochelatase; PFAM: Cobalt chelatase (CbiK). | 0.922 |
| ADW18745.1 | ADW19250.1 | Despr_2609 | Despr_3117 | COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR006367; KEGG: dak:DaAHT2_2550 siroheme synthase; SPTR: Siroheme synthase; TIGRFAM: siroheme synthase; TIGRFAM: siroheme synthase, N-terminal domain. | Sirohydrochlorin cobaltochelatase; COGs: COG4822 Cobalamin biosynthesis protein CbiK Co2+ chelatase; InterPro IPR010388; KEGG: dal:Dalk_0440 anaerobic cobalt chelatase; PFAM: anaerobic cobalt chelatase; PRIAM: Sirohydrochlorin cobaltochelatase; SPTR: Anaerobic cobalt chelatase; PFAM: Cobalt chelatase (CbiK). | 0.929 |
| ADW18745.1 | ADW19342.1 | Despr_2609 | Despr_3214 | COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR006367; KEGG: dak:DaAHT2_2550 siroheme synthase; SPTR: Siroheme synthase; TIGRFAM: siroheme synthase; TIGRFAM: siroheme synthase, N-terminal domain. | Anaerobic cobaltochelatase; COGs: COG4822 Cobalamin biosynthesis protein CbiK Co2+ chelatase; InterPro IPR010388; KEGG: dsa:Desal_2307 sirohydrochlorin cobaltochelatase; PFAM: anaerobic cobalt chelatase; PRIAM: Sirohydrochlorin cobaltochelatase; SPTR: Sirohydrochlorin cobaltochelatase; PFAM: Cobalt chelatase (CbiK). | 0.936 |
| ADW18745.1 | cobA | Despr_2609 | Despr_2576 | COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR006367; KEGG: dak:DaAHT2_2550 siroheme synthase; SPTR: Siroheme synthase; TIGRFAM: siroheme synthase; TIGRFAM: siroheme synthase, N-terminal domain. | COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR006366: IPR003043: IPR000878: IPR003754; KEGG: dps:DP1734 uroporphyrinogen III synthase/methyltransferase (HemD+CobA); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; SPTR: Probable uroporphyrinogen III synthase/methyltransferase (HemD+CobA); TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; Uroporphyrinogen-III synthase HemD; TIGRFAM: uroporphyrin-III C-methyltransferase. | 0.999 |
| ADW18745.1 | hemL | Despr_2609 | Despr_2958 | COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR006367; KEGG: dak:DaAHT2_2550 siroheme synthase; SPTR: Siroheme synthase; TIGRFAM: siroheme synthase; TIGRFAM: siroheme synthase, N-terminal domain. | COGs: COG0001 Glutamate-1-semialdehyde aminotransferase; InterPro IPR005814: IPR004639; KEGG: dps:DP0812 glutamate-1-semialdehyde 2,1-aminomutase; PFAM: aminotransferase class-III; SPTR: Glutamate-1-semialdehyde 2,1-aminomutase; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: Aminotransferase class-III; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase. | 0.933 |
| ADW19151.1 | ADW18745.1 | Despr_3018 | Despr_2609 | COGs: COG1010 Precorrin-3B methylase; InterPro IPR000878: IPR006363; KEGG: dps:DP0224 precorrin-3B C17-methyltransferase (CobJ); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Probable precorrin-3B C17-methyltransferase (CobJ); TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-3B C17-methyltransferase. | COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR006367; KEGG: dak:DaAHT2_2550 siroheme synthase; SPTR: Siroheme synthase; TIGRFAM: siroheme synthase; TIGRFAM: siroheme synthase, N-terminal domain. | 0.940 |
| ADW19151.1 | ADW19152.1 | Despr_3018 | Despr_3019 | COGs: COG1010 Precorrin-3B methylase; InterPro IPR000878: IPR006363; KEGG: dps:DP0224 precorrin-3B C17-methyltransferase (CobJ); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Probable precorrin-3B C17-methyltransferase (CobJ); TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-3B C17-methyltransferase. | COGs: COG2073 Cobalamin biosynthesis protein CbiG; InterPro IPR002750; KEGG: dak:DaAHT2_1587 cobalamin (vitamin B12) biosynthesis CbiG protein; PFAM: cobalamin (vitamin B12) biosynthesis CbiG protein; SPTR: Cobalamin (Vitamin B12) biosynthesis CbiG protein; PFAM: Cobalamin synthesis G C-terminus; Cobalamin synthesis G N-terminal. | 0.998 |
| ADW19151.1 | ADW19153.1 | Despr_3018 | Despr_3020 | COGs: COG1010 Precorrin-3B methylase; InterPro IPR000878: IPR006363; KEGG: dps:DP0224 precorrin-3B C17-methyltransferase (CobJ); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Probable precorrin-3B C17-methyltransferase (CobJ); TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-3B C17-methyltransferase. | COGs: COG2875 Precorrin-4 methylase; InterPro IPR000878: IPR003043: IPR006362; KEGG: dps:DP0222 precorrin-4 C11-methyltransferase (CobM); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-4 C(11)-methyltransferase; SPTR: Probable precorrin-4 C11-methyltransferase (CobM); TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-4 C11-methyltransferase. | 0.999 |
| ADW19151.1 | ADW19154.1 | Despr_3018 | Despr_3021 | COGs: COG1010 Precorrin-3B methylase; InterPro IPR000878: IPR006363; KEGG: dps:DP0224 precorrin-3B C17-methyltransferase (CobJ); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Probable precorrin-3B C17-methyltransferase (CobJ); TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-3B C17-methyltransferase. | COGs: COG2243 Precorrin-2 methylase; InterPro IPR000878: IPR012382: IPR006364; KEGG: dak:DaAHT2_1585 precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Precorrin-2 C20-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-2 C20-methyltransferase. | 0.999 |
| ADW19151.1 | ADW19162.1 | Despr_3018 | Despr_3029 | COGs: COG1010 Precorrin-3B methylase; InterPro IPR000878: IPR006363; KEGG: dps:DP0224 precorrin-3B C17-methyltransferase (CobJ); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Probable precorrin-3B C17-methyltransferase (CobJ); TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-3B C17-methyltransferase. | Anaerobic cobalt chelatase; COGs: COG4822 Cobalamin biosynthesis protein CbiK Co2+ chelatase; InterPro IPR010388; KEGG: dap:Dacet_0164 sirohydrochlorin cobaltochelatase; PFAM: anaerobic cobalt chelatase; SPTR: Sirohydrochlorin cobaltochelatase; PFAM: Cobalt chelatase (CbiK). | 0.905 |
| ADW19151.1 | ADW19250.1 | Despr_3018 | Despr_3117 | COGs: COG1010 Precorrin-3B methylase; InterPro IPR000878: IPR006363; KEGG: dps:DP0224 precorrin-3B C17-methyltransferase (CobJ); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Probable precorrin-3B C17-methyltransferase (CobJ); TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-3B C17-methyltransferase. | Sirohydrochlorin cobaltochelatase; COGs: COG4822 Cobalamin biosynthesis protein CbiK Co2+ chelatase; InterPro IPR010388; KEGG: dal:Dalk_0440 anaerobic cobalt chelatase; PFAM: anaerobic cobalt chelatase; PRIAM: Sirohydrochlorin cobaltochelatase; SPTR: Anaerobic cobalt chelatase; PFAM: Cobalt chelatase (CbiK). | 0.887 |