STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADW18866.1Glycine dehydrogenase (decarboxylating) beta subunit; COGs: COG1003 Glycine cleavage system protein P (pyridoxal-binding) C-terminal domain; InterPro IPR020580; KEGG: dps:DP0298 glycine dehydrogenase subunit 2; PFAM: Glycine cleavage system P-protein-like; SPTR: Probable glycine dehydrogenase, subunit 2; PFAM: Glycine cleavage system P-protein. (495 aa)    
Predicted Functional Partners:
ADW18867.1
Glycine dehydrogenase (decarboxylating) alpha subunit; COGs: COG0403 Glycine cleavage system protein P (pyridoxal-binding) N-terminal domain; InterPro IPR020580; KEGG: dps:DP0299 glycine dehydrogenase subunit 1; PFAM: Glycine cleavage system P-protein-like; PRIAM: Glycine dehydrogenase (decarboxylating); SPTR: Probable glycine dehydrogenase [decarboxylating] subunit 1; PFAM: Glycine cleavage system P-protein.
 0.999
ADW18868.1
COGs: COG0509 Glycine cleavage system H protein (lipoate-binding); InterPro IPR002930: IPR017453: IPR003016; KEGG: dps:DP0300 glycine cleavage system, H protein; PFAM: glycine cleavage H-protein; SPTR: Glycine cleavage system H protein; TIGRFAM: glycine cleavage system H protein; PFAM: Glycine cleavage H-protein; TIGRFAM: glycine cleavage system H protein.
 0.999
ADW18869.1
COGs: COG0404 Glycine cleavage system T protein (aminomethyltransferase); InterPro IPR006222; KEGG: dps:DP0301 glycine cleavage system, T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); SPTR: Related to glycine cleavage system, T protein; PFAM: Aminomethyltransferase folate-binding domain.
 0.999
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
 
 
 0.990
ADW19128.1
COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterProIPR013027: IPR004099: IPR000815: IPR012999: IPR 006258; KEGG: alv:Alvin_0803 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; SPTR: Dihydrolipoyl dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase.
 
 
 0.971
ADW16573.1
Fumarase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
   
    0.965
ADW17958.1
COGs: COG0151 Phosphoribosylamine-glycine ligase; InterProIPR000115: IPR000031: IPR020562: IPR020561: IPR 020560: IPR011761: IPR020559; KEGG: dps:DP2188 phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; PRIAM: Phosphoribosylamine--glycine ligase., Phosphoribosylaminoimidazole carboxylase; SPTR: Probable phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine/ [...]
  
  
 0.942
ADW16679.1
COGs: COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain; InterPro IPR017926: IPR010073: IPR000728: IPR010918; KEGG: dps:DP0704 phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein; PRIAM: Phosphoribosylformylglycinamidine synthase; SPTR: Probable phosphoribosylformylglycinamidine synthase; TIGRFAM: phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: phosphoribosylformylglycinamidine synt [...]
  
  
 0.862
ADW18912.1
COGs: COG0334 Glutamate dehydrogenase/leucine dehydrogenase; InterPro IPR006097: IPR006096: IPR006095; KEGG: dsa:Desal_1512 glutamate dehydrogenase; PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; PRIAM: Glutamate dehydrogenase (NADP(+)); SPTR: Glutamate dehydrogenase (NADP(+)); PFAM: Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Glu/Leu/Phe/Val dehydrogenase, dimerisation domain.
   
 0.859
glnA
COGs: COG0174 Glutamine synthetase; InterPro IPR004809: IPR008147: IPR008146; KEGG: dat:HRM2_45740 GlnA2; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; PRIAM: Glutamate--ammonia ligase; SPTR: Glutamine synthetase; TIGRFAM: glutamine synthetase, type I; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain; TIGRFAM: glutamine synthetase, type I.
   
 
 0.840
Your Current Organism:
Desulfobulbus propionicus
NCBI taxonomy Id: 577650
Other names: D. propionicus DSM 2032, Desulfobulbus propionicus DSM 2032, Desulfobulbus propionicus str. DSM 2032, Desulfobulbus propionicus strain DSM 2032
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.