Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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pilBCyclic nucleotide-binding protein; COGs: COG2804 Type II secretory pathway ATPase PulE/Tfp pilus assembly pathway ATPase PilB; InterProIPR000595: IPR007831: IPR001482: IPR003593: IPR 013374; KEGG: dps:DP2226 type IV pilus assembly protein (TapB); PFAM: type II secretion system protein E; General secretory system II protein E domain protein; cyclic nucleotide-binding; SMART: cyclic nucleotide-binding; AAA ATPase; SPTR: Probable type IV pilus assembly protein (TapB); TIGRFAM: type IV-A pilus assembly ATPase PilB; PFAM: GSPII_E N-terminal domain; Type II/IV secretion system protein; Cycli [...] (732 aa)    
Predicted Functional Partners:
ADW16843.1
General secretion pathway protein F; COGs: COG1459 Type II secretory pathway component PulF; InterPro IPR018076: IPR003004: IPR011850: IPR001992; KEGG: dol:Dole_1045 general secretion pathway protein F; PFAM: Type II secretion system F domain; SPTR: General secretion pathway protein F; TIGRFAM: general secretion pathway protein F; PFAM: Bacterial type II secretion system protein F domain; TIGRFAM: general secretion pathway protein F.
 
 
 0.958
ADW18341.1
Type II secretion system F domain protein; COGs: COG1459 Type II secretory pathway component PulF; InterPro IPR003004: IPR018076; KEGG: dps:DP2782 type 4 fimbrial assembly protein (PilC); PFAM: Type II secretion system F domain; SPTR: Probable type 4 fimbrial assembly protein (PilC); PFAM: Bacterial type II secretion system protein F domain.
 
 0.958
ADW16478.1
COGs: COG1989 Type II secretory pathway prepilin signal peptidase PulO and related peptidase; InterPro IPR014032: IPR010627: IPR000045; KEGG: dps:DP3017 type IV prepilin leader peptidase; PFAM: peptidase A24A domain protein; peptidase A24A prepilin type IV; PRIAM: Prepilin peptidase; SPTR: Related to type IV prepilin leader peptidase; PFAM: Bacterial Peptidase A24 N-terminal domain; Type IV leader peptidase family.
 
 
 0.862
ADW18966.1
Adenylate/guanylate cyclase with GAF sensor(s); COGs: COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain); InterPro IPR001054: IPR003018; KEGG: dal:Dalk_4220 adenylate/guanylate cyclase with GAF sensor(s); PFAM: GAF domain protein; adenylyl cyclase class-3/4/guanylyl cyclase; SMART: GAF domain protein; adenylyl cyclase class-3/4/guanylyl cyclase; SPTR: Adenylate/guanylate cyclase with GAF sensor(S); manually curated; PFAM: Adenylate and Guanylate cyclase catalytic domain; GAF domain.
  
 
 0.848
ADW18953.1
COGs: COG0463 Glycosyltransferase involved in cell wall biogenesis; InterPro IPR001173; KEGG: rfr:Rfer_2091 glycosyl transferase family protein; PFAM: glycosyl transferase family 2; SPTR: Glycosyl transferase, group 2 family protein; PFAM: Glycosyl transferase family 2.
     
 0.775
rpoB
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 
 0.751
ADW16832.1
General secretion pathway protein G; COGs: COG2165 Type II secretory pathway pseudopilin PulG; InterProIPR012902: IPR013545: IPR000983: IPR010054: IPR 001120; KEGG: dat:HRM2_11400 GspG1; PFAM: type II secretion system protein G; SPTR: GspG1; TIGRFAM: general secretion pathway protein G; PFAM: Prokaryotic N-terminal methylation motif; Bacterial type II secretion system protein G; TIGRFAM: general secretion pathway protein G; prepilin-type N-terminal cleavage/methylation domain.
 
 
 0.743
ADW16898.1
Adenylate/guanylate cyclase; COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR001789: IPR001054: IPR018297; KEGG: bja:blr2288 two-component hybrid sensor and regulator; PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; response regulator receiver; SMART: adenylyl cyclase class-3/4/guanylyl cyclase; response regulator receiver; SPTR: Adenylate/guanylate cyclase; PFAM: Adenylate and Guanylate cyclase catalytic domain; Response regulator receiver domain.
  
 
 0.737
rpoA
DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.729
rpoC
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 
 0.716
Your Current Organism:
Desulfobulbus propionicus
NCBI taxonomy Id: 577650
Other names: D. propionicus DSM 2032, Desulfobulbus propionicus DSM 2032, Desulfobulbus propionicus str. DSM 2032, Desulfobulbus propionicus strain DSM 2032
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