Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ADW18957.1Peptidase U32; COGs: COG0826 Collagenase and related protease; InterPro IPR001539; KEGG: dak:DaAHT2_0504 peptidase U32; PFAM: peptidase U32; SPTR: Peptidase U32; PFAM: Peptidase family U32. (751 aa)    
Predicted Functional Partners:
ADW18215.1
NAD(P)-dependent nickel-iron dehydrogenase flavin-containing subunit; COGs: COG1894 NADH:ubiquinone oxidoreductase NADH-binding (51 kD) subunit; InterPro IPR001949: IPR011538: IPR019554: IPR019575; KEGG: sus:Acid_5018 NADH dehydrogenase (quinone); PFAM: Respiratory-chain NADH dehydrogenase domain 51 kDa subunit; Soluble ligand binding domain; NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding; PRIAM: NADH dehydrogenase (quinone); SPTR: NADH dehydrogenase (Quinone); PFAM: NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Respiratory-chain NADH dehydrogenase 24 Kd [...]
    
   0.776
ADW17752.1
NAD(P)-dependent iron-only hydrogenase diaphorase component flavoprotein; COGs: COG1894 NADH:ubiquinone oxidoreductase NADH-binding (51 kD) subunit; InterProIPR011538: IPR019554: IPR019575: IPR017896: IPR 017900; KEGG: dma:DMR_07840 putative NAD-reducing hydrogenase subunit; PFAM: Respiratory-chain NADH dehydrogenase domain 51 kDa subunit; Soluble ligand binding domain; NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding; PRIAM: NADH dehydrogenase (quinone); SPTR: Putative NAD-reducing hydrogenase subunit; PFAM: NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; 4 [...]
  
   0.770
ADW16719.1
Methyltransferase type 11; InterPro IPR013216; KEGG: mba:Mbar_A0372 hypothetical protein; PFAM: Methyltransferase type 11; SPTR: Putative uncharacterized protein; PFAM: Methyltransferase domain.
  
  
 0.741
ADW18955.1
COGs: COG3307 Lipid A core - O-antigen ligase; InterPro IPR007016; KEGG: cpb:Cphamn1_0392 O-antigen polymerase; PFAM: O-antigen polymerase; SPTR: O-antigen polymerase; PFAM: O-Antigen ligase.
       0.559
ADW18956.1
Lipid A ABC exporter, fused ATPase and inner membrane subunits MsbA; COGs: COG1132 ABC-type multidrug transport system ATPase and permease components; InterProIPR003439: IPR017940: IPR011917: IPR001140: IPR 017871: IPR003593; KEGG: dps:DP2634 ABC transporter ATP-binding protein; PFAM: ABC transporter related; ABC transporter transmembrane region; SMART: AAA ATPase; SPTR: Lipid A export ATP-binding/permease protein MsbA; TIGRFAM: lipid A ABC exporter, fused ATPase and inner membrane subunits MsbA; PFAM: ABC transporter; ABC transporter transmembrane region; TIGRFAM: lipid A export perme [...]
       0.559
ADW18958.1
Histidine kinase; COGs: COG2205 Osmosensitive K+ channel histidine kinase; InterPro IPR005467: IPR003594; KEGG: dak:DaAHT2_0503 histidine kinase; PFAM: ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein; SPTR: Histidine kinase; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.
       0.552
ADW18959.1
COGs: COG2065 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase; InterPro IPR000836; KEGG: dak:DaAHT2_0502 uracil phosphoribosyltransferase; PFAM: phosphoribosyltransferase; PRIAM: Uracil phosphoribosyltransferase; SPTR: Uracil phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain.
       0.530
ADW18960.1
Formyl transferase domain protein; COGs: COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN; InterPro IPR002376: IPR001555; KEGG: dps:DP1615 phosphoribosylglycinamide formyltransferase; PFAM: formyl transferase domain protein; SPTR: Related to phosphoribosylglycinamide formyltransferase; PFAM: Formyl transferase.
  
    0.529
ADW18961.1
Phosphoribosylaminoimidazolecarboxamide formyltransferase; COGs: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); InterPro IPR011607: IPR013982; KEGG: dps:DP1614 bifunctional purine biosynthesis protein (PurH); PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region; PRIAM: Phosphoribosylaminoimidazolecarboxamide formyltransferase; SPTR: Probable bifunctional purine biosynthesis protein (PurH); PFAM: AICARFT/IMPCHase bienzyme; MGS-like domain.
       0.523
ADW18962.1
COGs: COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog); InterPro IPR002942; KEGG: tkm:TK90_2048 RNA-binding S4 domain protein; PFAM: RNA-binding S4 domain protein; SMART: RNA-binding S4 domain protein; SPTR: RNA-binding S4 domain protein; PFAM: S4 domain.
       0.482
Your Current Organism:
Desulfobulbus propionicus
NCBI taxonomy Id: 577650
Other names: D. propionicus DSM 2032, Desulfobulbus propionicus DSM 2032, Desulfobulbus propionicus str. DSM 2032, Desulfobulbus propionicus strain DSM 2032
Server load: low (40%) [HD]