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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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ADW19068.1COGs: COG0358 DNA primase; InterProIPR002694: IPR013264: IPR006171: IPR019475: IPR 006154: IPR006295; KEGG: dak:DaAHT2_2321 DNA primase; PFAM: DNA primase catalytic core domain; TOPRIM domain-containing protein; DNA primase, DnaB-helicase binding domain; SMART: Toprim sub domain-containing protein; SPTR: DNA primase; TIGRFAM: DNA primase; PFAM: Toprim domain; DNA primase catalytic core, N-terminal domain; CHC2 zinc finger; DnaB-helicase binding domain of primase; TIGRFAM: DNA primase, catalytic core. (596 aa)    
Predicted Functional Partners:
ADW19069.1
RNA polymerase, sigma 70 subunit, RpoD subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
 0.949
ADW17980.1
Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily.
 
 0.947
ADW17951.1
RNA polymerase, sigma 70 subunit, RpoD subfamily; COGs: COG0568 DNA-directed RNA polymerase sigma subunit (sigma70/sigma32); InterProIPR014284: IPR007127: IPR009042: IPR007627: IPR 007624: IPR007630: IPR000943; KEGG: dps:DP2503 RNA polymerase sigma factor (RpoD); PFAM: sigma-70 region 2 domain protein; sigma-70 region 1.2; sigma-70 1.1 domain protein; sigma-70 region 3 domain protein; sigma-70 region 4 domain protein; SPTR: RNA polymerase sigma factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70, region 4; Sigma-70 factor, region 1.1; Sigma-70 region 3; Sigma- [...]
  
 0.910
ADW16398.1
P4 alpha zinc-binding domain protein; COGs: COG0358 DNA primase; InterPro IPR013237; KEGG: dps:DP1572 hypothetical protein; PFAM: P4 alpha zinc-binding domain protein; SPTR: Putative uncharacterized protein; PFAM: CHC2 zinc finger.
     
  0.900
ADW17202.1
Ribosome-associated GTPase EngA; COGs: COG1160 GTPase; InterPro IPR006073: IPR016484: IPR002917: IPR005225; KEGG: dps:DP2939 GTP-binding protein (EngA); PFAM: GTP-binding protein HSR1-related; SPTR: GTP-binding protein engA; TIGRFAM: ribosome-associated GTPase EngA; small GTP-binding protein; PFAM: GTPase of unknown function; TIGRFAM: ribosome-associated GTPase EngA; small GTP-binding protein domain.
   
  
 0.871
ADW17755.1
Iron-only hydrogenase maturation protein HydF; COGs: COG1160 GTPase; InterPro IPR005225: IPR002917; KEGG: sfu:Sfum_1843 small GTP-binding protein; PFAM: GTP-binding protein HSR1-related; SPTR: Small GTP-binding protein; TIGRFAM: small GTP-binding protein; PFAM: GTPase of unknown function; TIGRFAM: small GTP-binding protein domain.
   
  
 0.862
ADW17116.1
Hypothetical protein; COGs: COG0305 Replicative DNA helicase; InterPro IPR007694; KEGG: ade:Adeh_1793 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: DnaB-like helicase C terminal domain.
  
 
 0.788
ADW16923.1
COGs: COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains; InterProIPR020046: IPR020047: IPR002562: IPR001098: IPR 002298: IPR018320: IPR019760: IPR002421: IPR008918; KEGG: dak:DaAHT2_1946 DNA polymerase I; PFAM: DNA-directed DNA polymerase; 5'-3' exonuclease, N-terminal resolvase-like domain; 5'-3' exonuclease, SAM-fold domain; 3'-5' exonuclease; PRIAM: DNA-directed DNA polymerase; SMART: 5'-3' exonuclease; Helix-hairpin-helix domain protein class 2; 3'-5' exonuclease; DNA-directed DNA polymerase; SPTR: DNA polymerase A; TIGRFAM: DNA polymerase I; PFAM: 5'-3' exonuclea [...]
 
  
 0.780
ADW19379.1
COGs: COG0223 Methionyl-tRNA formyltransferase; InterPro IPR005794: IPR002376: IPR005793: IPR001555; KEGG: dps:DP0747 methionyl-tRNA formyltransferase; PFAM: formyl transferase domain protein; SPTR: Methionyl-tRNA formyltransferase; TIGRFAM: methionyl-tRNA formyltransferase; PFAM: Formyl transferase; Formyl transferase, C-terminal domain; TIGRFAM: methionyl-tRNA formyltransferase.
 
  
 0.756
ADW17003.1
RNAse PH; COGs: COG0689 RNase PH; InterPro IPR001247: IPR015847: IPR002381: IPR018336; KEGG: dps:DP1273 ribonuclease PH; PFAM: 3' exoribonuclease; Exoribonuclease, phosphorolytic domain 2; PRIAM: tRNA nucleotidyltransferase; SPTR: Ribonuclease PH; TIGRFAM: ribonuclease PH; PFAM: 3' exoribonuclease family, domain 1; 3' exoribonuclease family, domain 2; TIGRFAM: ribonuclease PH.
    
 
 0.733
Your Current Organism:
Desulfobulbus propionicus
NCBI taxonomy Id: 577650
Other names: D. propionicus DSM 2032, Desulfobulbus propionicus DSM 2032, Desulfobulbus propionicus str. DSM 2032, Desulfobulbus propionicus strain DSM 2032
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