STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADW19350.1COGs: COG0788 Formyltetrahydrofolate hydrolase; InterPro IPR002912: IPR002376: IPR004810; KEGG: bvu:BVU_3850 formyltetrahydrofolate deformylase; PFAM: formyl transferase domain protein; amino acid-binding ACT domain protein; SPTR: Formyltetrahydrofolate deformylase; TIGRFAM: formyltetrahydrofolate deformylase; PFAM: Formyl transferase; TIGRFAM: formyltetrahydrofolate deformylase. (285 aa)    
Predicted Functional Partners:
folD
5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
 
 0.955
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.939
ADW18960.1
Formyl transferase domain protein; COGs: COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN; InterPro IPR002376: IPR001555; KEGG: dps:DP1615 phosphoribosylglycinamide formyltransferase; PFAM: formyl transferase domain protein; SPTR: Related to phosphoribosylglycinamide formyltransferase; PFAM: Formyl transferase.
 
  
0.939
ADW18869.1
COGs: COG0404 Glycine cleavage system T protein (aminomethyltransferase); InterPro IPR006222; KEGG: dps:DP0301 glycine cleavage system, T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); SPTR: Related to glycine cleavage system, T protein; PFAM: Aminomethyltransferase folate-binding domain.
  
 
 0.930
ADW19471.1
COGs: COG0262 Dihydrofolate reductase; InterPro IPR001796: IPR012259: IPR017925; KEGG: gsu:GSU0571 dihydrofolate reductase; PFAM: dihydrofolate reductase region; PRIAM: Dihydrofolate reductase; SPTR: Dihydrofolate reductase; PFAM: Dihydrofolate reductase.
    
 0.920
ADW18738.1
Homocysteine S-methyltransferase; COGs: COG0646 Methionine synthase I (cobalamin-dependent) methyltransferase domain; InterPro IPR003726; KEGG: dps:DP2201 5-methyltetrahydrofolate--homocysteine methyltransferase; PFAM: homocysteine S-methyltransferase; SPTR: Related to 5-methyltetrahydrofolate--homocysteine methyltransferase; PFAM: Homocysteine S-methyltransferase.
    
 0.912
ADW18737.1
COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterProIPR011822: IPR000489: IPR004223: IPR006158: IPR 003759; KEGG: dps:DP2202 5-methyltetrahydrofolate--homocysteine methyltransferase; PFAM: Vitamin B12 dependent methionine synthase activation region; dihydropteroate synthase DHPS; Methionine synthase B12-binding module cap domain protein; cobalamin B12-binding domain protein; PRIAM: Methionine synthase; SPTR: Related to 5-methyltetrahydrofolate--homocysteine methyltransferase; PFAM: Pterin binding enzyme; Vitamin B12 dependent methionine synthase, activation domain; B1 [...]
    
  0.904
ADW16802.1
4Fe-4S ferredoxin iron-sulfur binding domain protein; COGs: COG0437 Fe-S-cluster-containing hydrogenase components 1; InterPro IPR006311: IPR017900: IPR017909: IPR017896; KEGG: geo:Geob_1593 4Fe-4S ferredoxin iron-sulfur binding domain protein; SPTR: 4Fe-4S ferredoxin iron-sulfur binding domain protein; TIGRFAM: Tat (twin-arginine translocation) pathway signal sequence.
     
  0.900
ADW18049.1
4Fe-4S ferredoxin iron-sulfur binding domain-containing protein; COGs: COG0437 Fe-S-cluster-containing hydrogenase components 1; InterPro IPR017900: IPR017896: IPR014603; KEGG: drm:Dred_0462 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein; SPTR: 4Fe-4S ferredoxin, iron-sulfur binding domain protein.
     
  0.900
ADW18951.1
Thymidylate synthase complementing protein ThyX; COGs: COG1351 alternative thymidylate synthase; InterPro IPR003669; KEGG: dak:DaAHT2_0838 thymidylate synthase complementing protein ThyX; PFAM: thymidylate synthase complementing protein ThyX; SPTR: Thymidylate synthase complementing protein ThyX; PFAM: Thymidylate synthase complementing protein; TIGRFAM: thymidylate synthase, flavin-dependent.
     
  0.900
Your Current Organism:
Desulfobulbus propionicus
NCBI taxonomy Id: 577650
Other names: D. propionicus DSM 2032, Desulfobulbus propionicus DSM 2032, Desulfobulbus propionicus str. DSM 2032, Desulfobulbus propionicus strain DSM 2032
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