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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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ADW19374.1COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: dsa:Desal_2300 methylenetetrahydrofolate reductase (NAD(P)H); PFAM: methylenetetrahydrofolate reductase; PRIAM: Methylenetetrahydrofolate reductase (NAD(P)H); SPTR: Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase. (290 aa)    
Predicted Functional Partners:
ADW18737.1
COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterProIPR011822: IPR000489: IPR004223: IPR006158: IPR 003759; KEGG: dps:DP2202 5-methyltetrahydrofolate--homocysteine methyltransferase; PFAM: Vitamin B12 dependent methionine synthase activation region; dihydropteroate synthase DHPS; Methionine synthase B12-binding module cap domain protein; cobalamin B12-binding domain protein; PRIAM: Methionine synthase; SPTR: Related to 5-methyltetrahydrofolate--homocysteine methyltransferase; PFAM: Pterin binding enzyme; Vitamin B12 dependent methionine synthase, activation domain; B1 [...]
 
 
 0.992
ADW18738.1
Homocysteine S-methyltransferase; COGs: COG0646 Methionine synthase I (cobalamin-dependent) methyltransferase domain; InterPro IPR003726; KEGG: dps:DP2201 5-methyltetrahydrofolate--homocysteine methyltransferase; PFAM: homocysteine S-methyltransferase; SPTR: Related to 5-methyltetrahydrofolate--homocysteine methyltransferase; PFAM: Homocysteine S-methyltransferase.
 
 
 0.990
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.955
ADW19128.1
COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterProIPR013027: IPR004099: IPR000815: IPR012999: IPR 006258; KEGG: alv:Alvin_0803 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; SPTR: Dihydrolipoyl dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase.
    
 0.951
folD
5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.950
ADW18868.1
COGs: COG0509 Glycine cleavage system H protein (lipoate-binding); InterPro IPR002930: IPR017453: IPR003016; KEGG: dps:DP0300 glycine cleavage system, H protein; PFAM: glycine cleavage H-protein; SPTR: Glycine cleavage system H protein; TIGRFAM: glycine cleavage system H protein; PFAM: Glycine cleavage H-protein; TIGRFAM: glycine cleavage system H protein.
    
 0.939
ADW18869.1
COGs: COG0404 Glycine cleavage system T protein (aminomethyltransferase); InterPro IPR006222; KEGG: dps:DP0301 glycine cleavage system, T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); SPTR: Related to glycine cleavage system, T protein; PFAM: Aminomethyltransferase folate-binding domain.
  
 
 0.935
ADW18866.1
Glycine dehydrogenase (decarboxylating) beta subunit; COGs: COG1003 Glycine cleavage system protein P (pyridoxal-binding) C-terminal domain; InterPro IPR020580; KEGG: dps:DP0298 glycine dehydrogenase subunit 2; PFAM: Glycine cleavage system P-protein-like; SPTR: Probable glycine dehydrogenase, subunit 2; PFAM: Glycine cleavage system P-protein.
    
 0.928
ADW18867.1
Glycine dehydrogenase (decarboxylating) alpha subunit; COGs: COG0403 Glycine cleavage system protein P (pyridoxal-binding) N-terminal domain; InterPro IPR020580; KEGG: dps:DP0299 glycine dehydrogenase subunit 1; PFAM: Glycine cleavage system P-protein-like; PRIAM: Glycine dehydrogenase (decarboxylating); SPTR: Probable glycine dehydrogenase [decarboxylating] subunit 1; PFAM: Glycine cleavage system P-protein.
    
 0.928
ADW18951.1
Thymidylate synthase complementing protein ThyX; COGs: COG1351 alternative thymidylate synthase; InterPro IPR003669; KEGG: dak:DaAHT2_0838 thymidylate synthase complementing protein ThyX; PFAM: thymidylate synthase complementing protein ThyX; SPTR: Thymidylate synthase complementing protein ThyX; PFAM: Thymidylate synthase complementing protein; TIGRFAM: thymidylate synthase, flavin-dependent.
     
 0.911
Your Current Organism:
Desulfobulbus propionicus
NCBI taxonomy Id: 577650
Other names: D. propionicus DSM 2032, Desulfobulbus propionicus DSM 2032, Desulfobulbus propionicus str. DSM 2032, Desulfobulbus propionicus strain DSM 2032
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