STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADW19410.1COGs: COG0212 5-formyltetrahydrofolate cyclo-ligase; InterPro IPR002698; KEGG: dak:DaAHT2_1601 5-formyltetrahydrofolate cyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; SPTR: 5-formyltetrahydrofolate cyclo-ligase; TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase family; TIGRFAM: 5,10-methenyltetrahydrofolate synthetase. (202 aa)    
Predicted Functional Partners:
folD
5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.937
ADW18960.1
Formyl transferase domain protein; COGs: COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN; InterPro IPR002376: IPR001555; KEGG: dps:DP1615 phosphoribosylglycinamide formyltransferase; PFAM: formyl transferase domain protein; SPTR: Related to phosphoribosylglycinamide formyltransferase; PFAM: Formyl transferase.
  
 
 0.936
ADW17610.1
Protein of unknown function DUF488; COGs: COG3189 conserved hypothetical protein; InterPro IPR007438; KEGG: rmr:Rmar_2286 protein of unknown function DUF488; PFAM: protein of unknown function DUF488; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function, DUF488.
      0.622
ADW17589.1
COGs: COG0072 Phenylalanyl-tRNA synthetase beta subunit; InterProIPR004532: IPR002547: IPR005121: IPR005146: IPR 005147; KEGG: dps:DP1423 phenylalanyl-tRNA synthetase, beta chain; PFAM: B3/4 domain protein; t-RNA-binding domain-containing protein; tRNA synthetase B5; ferredoxin-fold anticodon-binding; SPTR: Phenylalanyl-tRNA synthetase beta chain; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; PFAM: tRNA synthetase B5 domain; B3/4 domain; Ferredoxin-fold anticodon binding domain; Putative tRNA binding domain; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bac [...]
 
  
 0.595
ADW19411.1
InterPro IPR007272; KEGG: dak:DaAHT2_2412 protein of unknown function DUF395 YeeE/YedE; PFAM: protein of unknown function DUF395 YeeE/YedE; SPTR: Putative uncharacterized protein; PFAM: YeeE/YedE family (DUF395).
       0.561
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.441
ADW16679.1
COGs: COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain; InterPro IPR017926: IPR010073: IPR000728: IPR010918; KEGG: dps:DP0704 phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein; PRIAM: Phosphoribosylformylglycinamidine synthase; SPTR: Probable phosphoribosylformylglycinamidine synthase; TIGRFAM: phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: phosphoribosylformylglycinamidine synt [...]
 
    0.429
ADW19409.1
COGs: COG4715 conserved hypothetical protein; InterPro IPR007527; KEGG: pca:Pcar_0899 hypothetical protein; SPTR: Zinc finger SWIM domain protein; PFAM: SWIM zinc finger.
       0.422
Your Current Organism:
Desulfobulbus propionicus
NCBI taxonomy Id: 577650
Other names: D. propionicus DSM 2032, Desulfobulbus propionicus DSM 2032, Desulfobulbus propionicus str. DSM 2032, Desulfobulbus propionicus strain DSM 2032
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