STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (829 aa)    
Predicted Functional Partners:
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
 
 0.999
ADW17672.1
DNA topoisomerase IV subunit B; COGs: COG0187 Type IIA topoisomerase (DNA gyrase/topo II topoisomerase IV) B subunit; InterPro IPR003594: IPR013506: IPR001241: IPR000565; KEGG: dps:DP2280 DNA topoisomerase IV subunit B; PFAM: DNA topoisomerase type IIA subunit B region 2 domain protein; ATP-binding region ATPase domain protein; SMART: DNA topoisomerase II; ATP-binding region ATPase domain protein; SPTR: Probable topoisomerase IV, subunit B; PFAM: Toprim domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; DNA gyrase B; DNA gyrase B subunit, carboxyl terminus.
 
 0.996
ADW17674.1
Abortive phage infection; InterPro IPR018891; KEGG: neu:NE0489 abortive infection phage resistance protein; PFAM: Abortive phage infection; SPTR: Possible abortive infection phage resistance protein; PFAM: AIPR protein.
  
 
 0.973
ADW16577.1
KEGG: dps:DP0713 hypothetical protein; SPTR: Putative uncharacterized protein.
   
   0.840
ADW16579.1
KEGG: dps:DP0712 hypothetical protein; SPTR: Putative uncharacterized protein; manually curated; PFAM: Putative exonuclease, RdgC.
   
   0.840
secA
Protein translocase subunit secA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane; Belongs to the SecA family.
 
  
 0.839
ADW19420.1
COGs: COG0240 Glycerol-3-phosphate dehydrogenase; InterPro IPR011128: IPR006109: IPR006168; KEGG: dps:DP0651 glycerol-3-phosphate dehydrogenase; PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; SPTR: Glycerol-3-phosphate dehydrogenase [NAD(P)+]; PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus.
     
 0.837
ADW16500.1
COGs: COG0143 Methionyl-tRNA synthetase; InterProIPR002547: IPR014758: IPR002304: IPR004495: IPR 015413; KEGG: dps:DP0786 methionyl-tRNA synthetase; PFAM: tRNA synthetase class I (M); t-RNA-binding domain-containing protein; SPTR: Probable methionyl-tRNA synthetase; TIGRFAM: methionyl-tRNA synthetase; methionyl-tRNA synthetase, beta subunit; PFAM: Anticodon-binding domain; tRNA synthetases class I (M); Putative tRNA binding domain; TIGRFAM: methionyl-tRNA synthetase C-terminal region/beta chain; methionyl-tRNA synthetase.
  
  
 0.805
ADW19084.1
COGs: COG0342 Preprotein translocase subunit SecD; InterPro IPR003335: IPR005791: IPR005665; KEGG: dps:DP0806 protein-export membrane protein SecD; PFAM: SecD/SecF/SecDF export membrane protein; SPTR: Related to protein-export membrane protein SecD; TIGRFAM: protein-export membrane protein SecD; protein-export membrane protein, SecD/SecF family; protein-export membrane protein SecF; PFAM: Protein export membrane protein; SecD/SecF GG Motif; TIGRFAM: protein-export membrane protein SecD; protein-export membrane protein, SecD/SecF family; protein-export membrane protein SecF.
  
  
 0.779
ADW17537.1
COGs: COG0337 3-dehydroquinate synthetase; InterPro IPR016037: IPR016303: IPR002658; KEGG: dak:DaAHT2_0294 3-dehydroquinate synthase; PFAM: 3-dehydroquinate synthase; PRIAM: 3-dehydroquinate synthase; SPTR: 3-dehydroquinate synthase; TIGRFAM: 3-dehydroquinate synthase; PFAM: 3-dehydroquinate synthase; TIGRFAM: 3-dehydroquinate synthase.
 
  
 0.751
Your Current Organism:
Desulfobulbus propionicus
NCBI taxonomy Id: 577650
Other names: D. propionicus DSM 2032, Desulfobulbus propionicus DSM 2032, Desulfobulbus propionicus str. DSM 2032, Desulfobulbus propionicus strain DSM 2032
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