STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
G8BIH7_CANPC2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2; Belongs to the DPH1/DPH2 family. DPH2 subfamily. (541 aa)    
Predicted Functional Partners:
G8BDK3_CANPC
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.
   
0.999
G8BDI2_CANPC
DPH-type MB domain-containing protein.
   
 0.998
G8B9J6_CANPC
TP_methylase domain-containing protein.
   
 0.948
G8BE22_CANPC
Tr-type G domain-containing protein.
    
 0.890
G8B7C8_CANPC
Tr-type G domain-containing protein.
    
 0.778
MEF1
Elongation factor G, mitochondrial; Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
    
 0.778
G8BD13_CANPC
Tr-type G domain-containing protein.
    
 0.778
MEF2
Ribosome-releasing factor 2, mitochondrial; Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
    
 0.778
G8B8V1_CANPC
Uncharacterized protein; Belongs to the DEAD box helicase family.
   
   0.743
G8BBQ1_CANPC
WD_REPEATS_REGION domain-containing protein.
   
    0.667
Your Current Organism:
Candida parapsilosis
NCBI taxonomy Id: 578454
Other names: C. parapsilosis CDC317, Candida parapsilosis CDC317
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.