STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
THITE_57831Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (511 aa)    
Predicted Functional Partners:
THITE_136252
Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family.
 
 
 0.992
THITE_135005
3-hydroxy-3-methylglutaryl coenzyme A reductase.
  
 0.989
THITE_35750
Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
   
 
 0.986
THITE_2115044
Uncharacterized protein.
 
      0.899
THITE_2113698
Uncharacterized protein.
 
      0.821
THITE_2109747
SH3 domain-containing protein.
    
   0.784
THITE_127590
3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
  
 
 0.778
THITE_2156279
Acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.758
THITE_129749
Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.
   
  
 0.698
THITE_66557
Nudix hydrolase domain-containing protein.
  
 
 0.690
Your Current Organism:
Thermothielavioides terrestris
NCBI taxonomy Id: 578455
Other names: T. terrestris NRRL 8126, Thermothielavioides terrestris NRRL 8126
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