STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
THITE_2114845Uncharacterized protein. (338 aa)    
Predicted Functional Partners:
THITE_2119121
Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.
    
 0.917
THITE_129744
Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.
  
  
0.916
THITE_42348
SET domain-containing protein.
     
 0.916
THITE_2118632
Uncharacterized protein; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.
    
0.915
THITE_68287
Uncharacterized protein.
   
 
 0.907
THITE_2111453
Uncharacterized protein.
     
0.902
THITE_113981
Histone domain-containing protein.
    
 0.563
THITE_109485
Histone H3; Belongs to the histone H3 family.
    
 0.563
THITE_74295
SIR2-like protein.
    
 0.552
THITE_62498
Chromo domain-containing protein.
    
 0.527
Your Current Organism:
Thermothielavioides terrestris
NCBI taxonomy Id: 578455
Other names: T. terrestris NRRL 8126, Thermothielavioides terrestris NRRL 8126
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.