STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
THITE_2115421SAP domain-containing protein. (645 aa)    
Predicted Functional Partners:
THITE_2119725
ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase.
  
 0.999
THITE_2108463
3'-5' exonuclease domain-containing protein.
    
 
 0.996
THITE_2080045
DNA ligase.
  
 0.945
THITE_2122946
Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
   
 0.927
THITE_2120798
AAA_23 domain-containing protein.
   
 0.890
THITE_2118716
Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily.
    
 0.888
THITE_2107729
BRCT domain-containing protein.
    
 0.877
THITE_48711
Uncharacterized protein.
   
 0.875
THITE_2108868
Uncharacterized protein.
    
 
 0.848
THITE_2107200
DNA_LIGASE_A3 domain-containing protein.
   
 0.842
Your Current Organism:
Thermothielavioides terrestris
NCBI taxonomy Id: 578455
Other names: T. terrestris NRRL 8126, Thermothielavioides terrestris NRRL 8126
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.