STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
D8Q4Q3_SCHCMPyruvate carboxyltransferase domain-containing protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (456 aa)    
Predicted Functional Partners:
D8PJY6_SCHCM
3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 
 0.971
D8PMR8_SCHCM
Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.
 
 
 0.968
D8Q886_SCHCM
Acetyl-coenzyme A synthetase.
  
 
 0.943
D8PR34_SCHCM
Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.925
D8QDC4_SCHCM
AcetylCoA_hyd_C domain-containing protein.
    
 0.922
D8Q9D5_SCHCM
Uncharacterized protein.
   
 
 0.921
D8Q0Q3_SCHCM
Uncharacterized protein.
    
 0.910
D8PKQ0_SCHCM
Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
     
 0.909
D8PV94_SCHCM
Pyruvate carboxyltransferase domain-containing protein.
   
 
 0.906
D8PP74_SCHCM
Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 
 0.847
Your Current Organism:
Schizophyllum commune
NCBI taxonomy Id: 578458
Other names: S. commune H4-8, Schizophyllum commune H4-8
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.