AMAG_01059 protein (Allomyces macrogynus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

AMAG_01059

Uncharacterized protein. (477 aa)

Predicted Functional Partners:

AMAG_02924

0.995

AMAG_19298

0.995

AMAG_00446

0.970

AMAG_17673

0.970

AMAG_01965

0.970

AMAG_01964

0.966

AMAG_08522

0.965

AMAG_09938

0.965

AMAG_14727

0.965

AMAG_15216

0.965

Your Current Organism:

Allomyces macrogynus

NCBI taxonomy Id: 578462
Other names: A. macrogynus ATCC 38327, Allomyces macrogynus ATCC 38327

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMAG_00446	AMAG_01059	A0A0L0RWK3	A0A0L0RYH3	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.970
AMAG_00446	AMAG_02924	A0A0L0RWK3	A0A0L0S484	Ubiquitin-like domain-containing protein.	ThiF domain-containing protein.	0.974
AMAG_00446	AMAG_08522	A0A0L0RWK3	A0A0L0SLW2	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.932
AMAG_00446	AMAG_09938	A0A0L0RWK3	A0A0L0SQD0	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.932
AMAG_00446	AMAG_14727	A0A0L0RWK3	A0A0L0T553	Ubiquitin-like domain-containing protein.	SUMO-conjugating enzyme ubc9; Belongs to the ubiquitin-conjugating enzyme family.	0.932
AMAG_00446	AMAG_15216	A0A0L0RWK3	A0A0L0T875	Ubiquitin-like domain-containing protein.	SUMO-conjugating enzyme ubc9; Belongs to the ubiquitin-conjugating enzyme family.	0.932
AMAG_00446	AMAG_19298	A0A0L0RWK3	A0A0L0SU58	Ubiquitin-like domain-containing protein.	ThiF domain-containing protein.	0.974
AMAG_01059	AMAG_00446	A0A0L0RYH3	A0A0L0RWK3	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.970
AMAG_01059	AMAG_01964	A0A0L0RYH3	A0A0L0S0P1	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.966
AMAG_01059	AMAG_01965	A0A0L0RYH3	A0A0L0S196	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.970
AMAG_01059	AMAG_02924	A0A0L0RYH3	A0A0L0S484	Uncharacterized protein.	ThiF domain-containing protein.	0.995
AMAG_01059	AMAG_08522	A0A0L0RYH3	A0A0L0SLW2	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.965
AMAG_01059	AMAG_09938	A0A0L0RYH3	A0A0L0SQD0	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.965
AMAG_01059	AMAG_14727	A0A0L0RYH3	A0A0L0T553	Uncharacterized protein.	SUMO-conjugating enzyme ubc9; Belongs to the ubiquitin-conjugating enzyme family.	0.965
AMAG_01059	AMAG_15216	A0A0L0RYH3	A0A0L0T875	Uncharacterized protein.	SUMO-conjugating enzyme ubc9; Belongs to the ubiquitin-conjugating enzyme family.	0.965
AMAG_01059	AMAG_17673	A0A0L0RYH3	A0A0L0RWQ9	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.970
AMAG_01059	AMAG_19298	A0A0L0RYH3	A0A0L0SU58	Uncharacterized protein.	ThiF domain-containing protein.	0.995
AMAG_01964	AMAG_01059	A0A0L0S0P1	A0A0L0RYH3	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.966
AMAG_01964	AMAG_02924	A0A0L0S0P1	A0A0L0S484	Ubiquitin-like domain-containing protein.	ThiF domain-containing protein.	0.972
AMAG_01964	AMAG_08522	A0A0L0S0P1	A0A0L0SLW2	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.892

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Network Stats

number of nodes:

11

number of edges:

12

average node degree:

2.18

avg. local clustering coefficient:

0.883

expected number of edges:

13

PPI enrichment p-value:

0.649

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030509

BMP signaling pathway

7 of 81

2.19

4.81

3.05e-11

GO:0045667

Regulation of osteoblast differentiation

7 of 91

2.14

4.64

4.63e-11

GO:0090092

Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

9 of 201

1.91

4.53

8.00e-13

GO:0030500

Regulation of bone mineralization

6 of 58

2.27

4.45

5.40e-10

GO:0009953

Dorsal/ventral pattern formation

6 of 66

2.22

4.26

9.98e-10

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004675

Transmembrane receptor protein serine/threonine kinase activity

6 of 17

2.81

6.21

1.58e-12

GO:0036122

BMP binding

6 of 20

2.73

6.12

1.80e-12

GO:0019955

Cytokine binding

7 of 128

2.0

4.11

1.78e-10

GO:0005024

Transforming growth factor beta receptor activity

4 of 10

2.86

4.06

2.96e-08

GO:0098821

BMP receptor activity

3 of 6

2.96

2.9

5.16e-06

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0048179

Activin receptor complex

3 of 7

2.89

2.6

1.74e-05

GO:0043235

Receptor complex

6 of 340

1.5

1.78

1.74e-05

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37300483

(2024) BMP7 expression in mammalian cortical radial glial cells increases the length of the neurogenic period.

4 of 49

2.17

2.21

4.51e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:16804

Signaling by BMP, and Transforming growth factor beta, conserved site

11 of 54

2.57

11.08

7.90e-25

CL:16864

TGF-beta propeptide, and BMP receptor activity

9 of 24

2.83

10.58

1.35e-21

CL:16865

TGF-beta propeptide, and Transforming growth factor beta receptor activity, type I

8 of 18

2.91

9.64

2.58e-19

CL:16867

TGF-beta propeptide, and Transforming growth factor beta receptor activity, type I

5 of 13

2.84

5.38

8.16e-11

CL:16855

Activin receptor complex, and Negative regulation of myoblast proliferation

2 of 5

2.86

1.41

0.0028

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04350

TGF-beta signaling pathway

11 of 108

2.27

8.86

7.53e-23

map04060

Cytokine-cytokine receptor interaction

7 of 285

1.65

2.84

7.43e-09

map05418

Fluid shear stress and atherosclerosis

5 of 151

1.78

2.47

1.43e-06

map04550

Signaling pathways regulating pluripotency of stem cells

5 of 154

1.77

2.46

1.43e-06

map04390

Hippo signaling pathway

4 of 166

1.64

1.7

0.00011

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-201451

Signaling by BMP

7 of 26

2.69

7.15

9.63e-15

MAP-9006936

Signaling by TGFB family members

8 of 122

2.07

5.17

3.64e-13

MAP-1502540

Signaling by Activin

2 of 14

2.41

1.01

0.0140

MAP-162582

Signal Transduction

8 of 2927

0.69

0.47

0.0135

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0048179

Activin receptor complex

3 of 5

3.04

2.95

4.19e-06

GOCC:0070724

BMP receptor complex

3 of 6

2.96

2.92

4.72e-06

GOCC:0098802

Plasma membrane signaling receptor complex

6 of 182

1.78

2.61

5.21e-07

GOCC:0005887

Integral component of plasma membrane

6 of 408

1.43

1.71

1.18e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0723

Serine/threonine-protein kinase

6 of 190

1.76

2.76

1.28e-07

KW-0464

Manganese

3 of 54

2.0

1.8

0.00025

KW-0964

Secreted

4 of 266

1.43

1.32

0.00050

KW-0460

Magnesium

3 of 128

1.63

1.27

0.0017

KW-0067

ATP-binding

6 of 781

1.14

1.11

0.00017

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01064

Activin types I and II receptor domain

5 of 8

3.05

5.59

4.92e-11

PF00069

Protein kinase domain

3 of 34

2.2

1.58

0.0010

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000333

Ser/Thr protein kinase, TGFB receptor

6 of 12

2.96

6.51

6.74e-13

IPR000472

Activin types I and II receptor domain

5 of 10

2.96

5.34

1.21e-10

IPR045860

Snake toxin-like superfamily

6 of 36

2.48

5.04

9.47e-11

IPR029034

Cystine-knot cytokine

4 of 63

2.06

2.09

6.47e-05

IPR017159

Gremlin-1/2

2 of 2

3.26

1.55

0.0016

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00467

GS motif

2 of 7

2.71

1.16

0.0079

SM00041

C-terminal cystine knot-like domain (CTCK)

2 of 17

2.33

0.94

0.0187

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