AMAG_06464 protein (Allomyces macrogynus) - STRING interaction network

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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Score

AMAG_06464

TIP120 domain-containing protein. (1266 aa)

Predicted Functional Partners:

AMAG_04595

0.994

AMAG_04672

0.974

AMAG_03390

0.974

AMAG_07578

0.969

AMAG_16949

0.969

AMAG_00688

0.966

AMAG_02188

0.966

AMAG_06543

0.945

AMAG_03826

0.926

AMAG_06993

0.926

Your Current Organism:

Allomyces macrogynus

NCBI taxonomy Id: 578462
Other names: A. macrogynus ATCC 38327, Allomyces macrogynus ATCC 38327

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMAG_00688	AMAG_03390	A0A0L0RWJ7	A0A0L0S9C5	CULLIN_2 domain-containing protein; Belongs to the cullin family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.806
AMAG_00688	AMAG_03826	A0A0L0RWJ7	A0A0L0SAZ0	CULLIN_2 domain-containing protein; Belongs to the cullin family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.733
AMAG_00688	AMAG_04595	A0A0L0RWJ7	A0A0L0S5F0	CULLIN_2 domain-containing protein; Belongs to the cullin family.	E3 ubiquitin-protein ligase RBX1.	0.995
AMAG_00688	AMAG_04672	A0A0L0RWJ7	A0A0L0S630	CULLIN_2 domain-containing protein; Belongs to the cullin family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.810
AMAG_00688	AMAG_06464	A0A0L0RWJ7	A0A0L0SGT3	CULLIN_2 domain-containing protein; Belongs to the cullin family.	TIP120 domain-containing protein.	0.966
AMAG_00688	AMAG_06543	A0A0L0RWJ7	A0A0L0T7D0	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Uncharacterized protein; Belongs to the SKP1 family.	0.994
AMAG_00688	AMAG_06993	A0A0L0RWJ7	A0A0L0SFH0	CULLIN_2 domain-containing protein; Belongs to the cullin family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.733
AMAG_02188	AMAG_03390	A0A0L0S1B8	A0A0L0S9C5	CULLIN_2 domain-containing protein; Belongs to the cullin family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.809
AMAG_02188	AMAG_03826	A0A0L0S1B8	A0A0L0SAZ0	CULLIN_2 domain-containing protein; Belongs to the cullin family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.735
AMAG_02188	AMAG_04595	A0A0L0S1B8	A0A0L0S5F0	CULLIN_2 domain-containing protein; Belongs to the cullin family.	E3 ubiquitin-protein ligase RBX1.	0.995
AMAG_02188	AMAG_04672	A0A0L0S1B8	A0A0L0S630	CULLIN_2 domain-containing protein; Belongs to the cullin family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.812
AMAG_02188	AMAG_06464	A0A0L0S1B8	A0A0L0SGT3	CULLIN_2 domain-containing protein; Belongs to the cullin family.	TIP120 domain-containing protein.	0.966
AMAG_02188	AMAG_06543	A0A0L0S1B8	A0A0L0T7D0	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Uncharacterized protein; Belongs to the SKP1 family.	0.994
AMAG_02188	AMAG_06993	A0A0L0S1B8	A0A0L0SFH0	CULLIN_2 domain-containing protein; Belongs to the cullin family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.734
AMAG_03390	AMAG_00688	A0A0L0S9C5	A0A0L0RWJ7	CULLIN_2 domain-containing protein; Belongs to the cullin family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.806
AMAG_03390	AMAG_02188	A0A0L0S9C5	A0A0L0S1B8	CULLIN_2 domain-containing protein; Belongs to the cullin family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.809
AMAG_03390	AMAG_03826	A0A0L0S9C5	A0A0L0SAZ0	CULLIN_2 domain-containing protein; Belongs to the cullin family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.474
AMAG_03390	AMAG_04595	A0A0L0S9C5	A0A0L0S5F0	CULLIN_2 domain-containing protein; Belongs to the cullin family.	E3 ubiquitin-protein ligase RBX1.	0.997
AMAG_03390	AMAG_06464	A0A0L0S9C5	A0A0L0SGT3	CULLIN_2 domain-containing protein; Belongs to the cullin family.	TIP120 domain-containing protein.	0.974
AMAG_03390	AMAG_06543	A0A0L0S9C5	A0A0L0T7D0	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Uncharacterized protein; Belongs to the SKP1 family.	0.606

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Network Stats

number of nodes:

7

number of edges:

21

average node degree:

6

avg. local clustering coefficient:

1

expected number of edges:

8

PPI enrichment p-value:

3.49e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000162

Tryptophan biosynthetic process

5 of 5

2.58

4.14

1.23e-08

GO:0008652

Cellular amino acid biosynthetic process

6 of 98

1.37

1.67

6.86e-06

GO:0019752

Carboxylic acid metabolic process

7 of 329

0.91

0.81

0.00030

GO:0009058

Biosynthetic process

9 of 752

0.66

0.55

0.00040

GO:0044249

Cellular biosynthetic process

8 of 696

0.64

0.49

0.0028

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004834

Tryptophan synthase activity

2 of 2

2.58

1.05

0.0124

GO:0016829

Lyase activity

5 of 119

1.21

0.87

0.0054

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:888

Aromatic amino acid biosynthesis, and ADC synthase

9 of 15

2.36

7.42

3.94e-17

CL:886

Phenylalanine, tyrosine and tryptophan biosynthesis, and Histidine biosynthetic process

10 of 33

2.06

6.26

3.94e-17

CL:891

Tryptophan biosynthesis

5 of 5

2.58

4.63

1.20e-09

CL:884

Biosynthesis of amino acids

11 of 94

1.65

4.06

3.06e-16

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00400

Phenylalanine, tyrosine and tryptophan biosynthesis

8 of 25

2.09

5.37

1.14e-13

map01230

Biosynthesis of amino acids

10 of 131

1.47

2.86

8.46e-13

map01110

Biosynthesis of secondary metabolites

10 of 509

0.88

0.95

3.00e-07

map00260

Glycine, serine and threonine metabolism

3 of 45

1.41

0.95

0.0068

map01100

Metabolic pathways

10 of 1538

0.4

0.31

0.0080

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0822

Tryptophan biosynthesis

5 of 5

2.58

4.5

2.14e-09

KW-0028

Amino-acid biosynthesis

6 of 57

1.61

2.39

2.59e-07

KW-0456

Lyase

3 of 71

1.21

0.61

0.0398

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04715

Anthranilate synthase component I, N terminal region

2 of 2

2.58

0.91

0.0224

PF00425

Chorismate binding enzyme

2 of 2

2.58

0.91

0.0224

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR011060

Ribulose-phosphate binding barrel

4 of 7

2.34

2.55

1.25e-05

IPR013785

Aldolase-type TIM barrel

5 of 48

1.6

1.7

8.60e-05

IPR019999

Anthranilate synthase component I-like

2 of 2

2.58

0.95

0.0189

IPR015890

Chorismate-utilising enzyme, C-terminal

2 of 2

2.58

0.95

0.0189

IPR005801

ADC synthase

2 of 2

2.58

0.95

0.0189

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