AMAG_09141 protein (Allomyces macrogynus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

AMAG_09141

Uncharacterized protein. (764 aa)

Predicted Functional Partners:

AMAG_05106

0.832

AMAG_12701

0.802

AMAG_14666

0.747

AMAG_17224

0.637

AMAG_07851

0.510

AMAG_09640

0.510

AMAG_05798

0.483

AMAG_12238

0.483

AMAG_06167

0.481

AMAG_09203

0.481

Your Current Organism:

Allomyces macrogynus

NCBI taxonomy Id: 578462
Other names: A. macrogynus ATCC 38327, Allomyces macrogynus ATCC 38327

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMAG_05106	AMAG_06167	A0A0L0S6Y9	A0A0L0SE40	acidPPc domain-containing protein.	DAO_C domain-containing protein.	0.736
AMAG_05106	AMAG_09141	A0A0L0S6Y9	A0A0L0SNJ8	acidPPc domain-containing protein.	Uncharacterized protein.	0.832
AMAG_05106	AMAG_09203	A0A0L0S6Y9	A0A0L0SP42	acidPPc domain-containing protein.	Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.	0.736
AMAG_05106	AMAG_12701	A0A0L0S6Y9	A0A0L0T1D3	acidPPc domain-containing protein.	Uncharacterized protein.	0.902
AMAG_05106	AMAG_14666	A0A0L0S6Y9	A0A0L0T7L9	acidPPc domain-containing protein.	Uncharacterized protein.	0.861
AMAG_05106	AMAG_17224	A0A0L0S6Y9	A0A0L0TEM2	acidPPc domain-containing protein.	Uncharacterized protein.	0.898
AMAG_05798	AMAG_09141	A0A0L0SD84	A0A0L0SNJ8	AB hydrolase-1 domain-containing protein.	Uncharacterized protein.	0.483
AMAG_05798	AMAG_17224	A0A0L0SD84	A0A0L0TEM2	AB hydrolase-1 domain-containing protein.	Uncharacterized protein.	0.811
AMAG_06167	AMAG_05106	A0A0L0SE40	A0A0L0S6Y9	DAO_C domain-containing protein.	acidPPc domain-containing protein.	0.736
AMAG_06167	AMAG_09141	A0A0L0SE40	A0A0L0SNJ8	DAO_C domain-containing protein.	Uncharacterized protein.	0.481
AMAG_06167	AMAG_12701	A0A0L0SE40	A0A0L0T1D3	DAO_C domain-containing protein.	Uncharacterized protein.	0.854
AMAG_06167	AMAG_14666	A0A0L0SE40	A0A0L0T7L9	DAO_C domain-containing protein.	Uncharacterized protein.	0.883
AMAG_07851	AMAG_09141	A0A0L0SJJ5	A0A0L0SNJ8	Uncharacterized protein.	Uncharacterized protein.	0.510
AMAG_09141	AMAG_05106	A0A0L0SNJ8	A0A0L0S6Y9	Uncharacterized protein.	acidPPc domain-containing protein.	0.832
AMAG_09141	AMAG_05798	A0A0L0SNJ8	A0A0L0SD84	Uncharacterized protein.	AB hydrolase-1 domain-containing protein.	0.483
AMAG_09141	AMAG_06167	A0A0L0SNJ8	A0A0L0SE40	Uncharacterized protein.	DAO_C domain-containing protein.	0.481
AMAG_09141	AMAG_07851	A0A0L0SNJ8	A0A0L0SJJ5	Uncharacterized protein.	Uncharacterized protein.	0.510
AMAG_09141	AMAG_09203	A0A0L0SNJ8	A0A0L0SP42	Uncharacterized protein.	Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.	0.481
AMAG_09141	AMAG_09640	A0A0L0SNJ8	A0A0L0SSV6	Uncharacterized protein.	Uncharacterized protein.	0.510
AMAG_09141	AMAG_12238	A0A0L0SNJ8	A0A0L0SX80	Uncharacterized protein.	AB hydrolase-1 domain-containing protein.	0.483

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.88

expected number of edges:

12

PPI enrichment p-value:

7.14e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006099

Tricarboxylic acid cycle

4 of 30

2.15

2.12

6.84e-05

GO:0006097

Glyoxylate cycle

2 of 2

3.03

1.41

0.0029

GO:0005975

Carbohydrate metabolic process

6 of 447

1.16

0.96

0.0014

GO:0006094

Gluconeogenesis

2 of 12

2.25

0.84

0.0289

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046912

Acyltransferase activity, acyl groups converted into alkyl on transfer

3 of 13

2.39

1.75

0.00054

GO:0042132

Fructose 1,6-bisphosphate 1-phosphatase activity

2 of 2

3.03

1.34

0.0038

GO:0004108

Citrate (Si)-synthase activity

2 of 2

3.03

1.34

0.0038

GO:0016746

Acyltransferase activity

4 of 188

1.36

0.95

0.0055

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009514

Glyoxysome

2 of 2

3.03

1.33

0.0039

GO:0042597

Periplasmic space

2 of 4

2.73

1.27

0.0049

GO:0005777

Peroxisome

3 of 82

1.59

0.93

0.0118

GO:0005737

Cytoplasm

11 of 4517

0.42

0.32

0.0074

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9454

Citrate synthase, and Citrate metabolic process

2 of 5

2.63

0.82

0.0323

CL:17099

Mixed, incl. Sequestering of actin monomers, and C4-dicarboxylate transmembrane transporter activity

2 of 5

2.63

0.82

0.0323

CL:11084

Glyoxysome, and Isocitrate lyase

2 of 5

2.63

0.82

0.0323

CL:10111

Glycolytic process, and Insulin effects increased synthesis of Xylulose-5-Phosphate

2 of 18

2.07

0.74

0.0415

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

plj01200

Carbon metabolism

6 of 113

1.75

2.86

5.15e-08

plj00630

Glyoxylate and dicarboxylate metabolism

4 of 36

2.07

2.72

2.29e-06

plj00020

Citrate cycle (TCA cycle)

2 of 28

1.88

1.06

0.0084

plj01210

2-Oxocarboxylic acid metabolism

2 of 32

1.82

1.04

0.0090

plj01110

Biosynthesis of secondary metabolites

5 of 415

1.11

0.96

0.00090

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009514

Glyoxysome

2 of 3

2.85

1.17

0.0078

GOCC:0042597

Periplasmic space

2 of 13

2.22

0.76

0.0406

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00316

Fructose-1-6-bisphosphatase, N-terminal domain

2 of 2

3.03

1.28

0.0050

PF00285

Citrate synthase, C-terminal domain

2 of 3

2.85

1.27

0.0050

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR044015

Fructose-1-6-bisphosphatase class 1, C-terminal

2 of 2

3.03

1.03

0.0141

IPR033391

Fructose-1-6-bisphosphatase class I, N-terminal

2 of 2

3.03

1.03

0.0141

IPR020548

Fructose-1,6-bisphosphatase, active site

2 of 2

3.03

1.03

0.0141

IPR019810

Citrate synthase active site

2 of 2

3.03

1.03

0.0141

IPR000146

Fructose-1,6-bisphosphatase class 1

2 of 2

3.03

1.03

0.0141

(more ...)

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